8-acetoxy-2-chloroquinoline | 100822-30-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 8-acetoxy-2-chloroquinoline
• 英文别名: (2-chloroquinolin-8-yl) acetate
• CAS: 100822-30-8
• 化学式: C₁₁H₈ClNO₂
• 分子量: 221.643
• InChiKey: VQHKXOCWWFNWIB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  39.2
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  8-acetoxy-2-chloroquinoline 在 氢氧化钾 作用下， 以 乙醇 为溶剂， 反应 1.0h， 以72%的产率得到2-氯-8-羟基喹啉
  参考文献：
  名称：

  Improved syntheses of some monochloro- and monobromo-8-quinolinols

  摘要：

  Procedures were developed for the preparation of the 2-, 3-, 4-, and 6-monosubstituted chloro and bromo 8-quinolinols which afforded greater yields and/or reduced the number of steps in the preparation. 100 MHz H-1-NMR spectra for the 12 possible monochloro and monobromo analogues are given.

  DOI：

  10.1007/bf00823423
• 作为产物：
  描述：

  2-氧代-1,2-二氢喹啉-8-基 乙酸酯 在 三氯氧磷 作用下， 反应 25.0h， 以77%的产率得到8-acetoxy-2-chloroquinoline
  参考文献：
  名称：

  Improved syntheses of some monochloro- and monobromo-8-quinolinols

  摘要：

  Procedures were developed for the preparation of the 2-, 3-, 4-, and 6-monosubstituted chloro and bromo 8-quinolinols which afforded greater yields and/or reduced the number of steps in the preparation. 100 MHz H-1-NMR spectra for the 12 possible monochloro and monobromo analogues are given.

  DOI：

  10.1007/bf00823423

文献信息

• [EN] 8-HYDROXY QUINOLINE DERIVATIVES<br/>[FR] DERIVES DE QUINOLINE 8-HYDROXY
  申请人：PRANA BIOTECHNOLOGY LTD

  公开号：WO2004007461A1

  公开（公告）日：2004-01-22

  The present invention relates to a method for the treatment, amelioration and/or prophylaxis of a neurological condition, in particular neurodegenerative disorders which comprises the administration of an effective amount of a compound of formula (I): to a subject in need thereof. The present invention also relates to a compound of formula (II) and processes for its preparation.

  本发明涉及一种用于治疗、改善和/或预防神经系统疾病，特别是神经退行性疾病的方法，包括向需要的受试者施用化合物(I)的有效量。本发明还涉及一种化合物(II)及其制备方法。
• 8-HYDROXY QUINOLINE DERIVATIVES
  申请人：PRANA BIOTECHNOLOGY LIMITED

  公开号：US20150094334A1

  公开（公告）日：2015-04-02

  The present invention describes a method for the treatment of a neurological condition in a subject which comprises administering to a subject in need thereof a therapeutically effect amount of a compound of the formula or pharmaceutically acceptable salts, hydrates, or solvates thereof.

  本发明描述了一种治疗受试者神经疾病的方法，包括向需要治疗的受试者施用公式中的化合物或其药学上可接受的盐、水合物或溶剂化物的治疗有效量。
• 8-Hydroxy quinoline derivatives
  申请人：Barnham Jeffrey Kevin

  公开号：US20060089380A1

  公开（公告）日：2006-04-27

  The present invention relates to a method for the treatment, amelioration and/or prophylaxis of a neurological condition, in particular neurodegenerative disorders which comprises the administration of an effective amount of a compound of formula (I): to a subject in need thereof. The present invention also relates to a compound of formula (II) and processes for its preparation.

  本发明涉及一种用于治疗、改善和/或预防神经系统疾病的方法，特别是神经退行性疾病，该方法包括向需要治疗的受体中给予式（I）的化合物的有效量。本发明还涉及式（II）的化合物及其制备方法。
• EP1539700A4
  申请人：——

  公开号：EP1539700A4

  公开（公告）日：2006-06-28
• US7619091B2
  申请人：——

  公开号：US7619091B2

  公开（公告）日：2009-11-17