2-phenanthridin-6-yl-propane-1,3-diol | 126430-66-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-phenanthridin-6-yl-propane-1,3-diol
• 英文别名: 2-Phenanthridin-6-yl-propan-1,3-diol；6-(2-Hydroxy-1-hydroxymethylethyl)-phenanthridine；2-phenanthridin-6-ylpropane-1,3-diol
• CAS: 126430-66-8
• 化学式: C₁₆H₁₅NO₂
• 分子量: 253.301
• InChiKey: GPPDJIFSUBMQAO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  53.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-phenanthridin-6-yl-propane-1,3-diol 在 盐酸 、 potassium dichromate 、 硫酸 作用下， 生成 ethyl phenanthridine-6-carboxylate
  参考文献：
  名称：

  29.菲啶系列的研究。第三部分 介观取代的衍生物

  摘要：

  DOI：

  10.1039/jr9340000104
• 作为产物：
  描述：

  聚合甲醛 、 6-甲基菲啶 在 乙醇 作用下， 生成 2-phenanthridin-6-yl-propane-1,3-diol
  参考文献：
  名称：

  29.菲啶系列的研究。第三部分 介观取代的衍生物

  摘要：

  DOI：

  10.1039/jr9340000104

文献信息

• Nitro substituted chemiluminescent labels and their conjugates, and
  申请人：London Diagnostics, Inc.

  公开号：US05290936A1

  公开（公告）日：1994-03-01

  A novel chemiluminescent labeling compositions comprising an ester, thiolester or amide covalently and jointly bonded to (1) a carbon of a heterocyclic ring or ring system that is susceptible to attack by peroxide or molecular oxygen and (2) an aryl ring or ring system wherein the heterocyclic ring or ring system is distinguished by a heteroatom thereof in an oxidation state which causes the attacked carbon atom to form an intermediate that decays and produces chemiluminescence; the aryl ring or ring system contains at least three substituents on a six-member aromatic hydrocarbon that together sterically and electronically hinder hydrolysis of the linkage, which substituents involve ortho substituent groups on the aryl in conjunction with --NO.sub.2 meta or para substituents thereon. Included are the chemiluminescent labeling composition conjugated with a specific binding material; a chemiluminescent assay comprising the conjugate; and a chemiluminescent assay kit comprising the conjugate with the capability of conducting the assay.

  一种新型的化学发光标记组合物，包括酯、硫酯或酰胺共价地结合在（1）易受过氧化物或分子氧攻击的杂环环或环系统的碳上和（2）含有芳基环或环系统的芳基环或环系统上，其中杂环环或环系统以其中的一个杂原子的氧化状态区分，使被攻击的碳原子形成一个中间体，该中间体衰变并产生化学发光；芳基环或环系统在一个六元芳香烃上至少含有三个取代基，这些取代基在电子和立体上共同阻碍连接的水解，这些取代基包括联合在芳基上的邻位取代基和其上的—NO.sub.2的间位或对位取代基。该组合物包括与特定结合物共轭的化学发光标记组合物；包括该共轭物的化学发光测定；以及包括具有进行测定能力的该共轭物的化学发光测定试剂盒。
• Hydrolytically stable chemiluminescent labels and their conjugates, and
  申请人：London Diagnostics, Inc.

  公开号：US05284951A1

  公开（公告）日：1994-02-08

  A novel chemiluminescent labeling compositions comprising an ester, thioester or amide covalently and jointly bonded to (1) a carbon of a heterocyclic ring or ring system that is susceptible to attack by peroxide or molecular oxygen and (2) an aryl ring or ring system wherein the heterocyclic ring or ring system is distinguished by a heteroatom thereof in an oxidation state which causes the attacked carbon atom to form an intermediate that decays and produces chemiluminescence; the aryl ring or ring system contains at least three substituents on a six-member aromatic hydrocarbon that together sterically and electronically hinder hydrolysis of the linkage, which substituents involve ortho substituent groups on the aryl in conjunction with meta and/or para substituents thereon that possess an electron withdrawing capacity characterized as a .sigma..sub.p value greater than 0 and less than 1. Included are the chemiluminescent labeling composition conjugated with a specific binding material; a chemiluminescent assay comprising the conjugate; and a chemiluminescent assay kit comprising the conjugate with the capability of conducting the assay.

  一种新型的化学发光标记组合物，包括酯、硫酯或酰胺，它们与(1)易受过氧化物或分子氧攻击的杂环环或环系的碳共价结合，并且(2)芳香环或环系，其中杂环环或环系的异原子处于氧化状态，使受攻击的碳原子形成中间体，衰减并产生化学发光；芳香环或环系在六元芳香烃上至少有三个取代基，它们在空间和电子上共同阻碍连接的水解，这些取代基包括芳香族上的邻位取代基和其上的间位和/或对位取代基，具有大于0且小于1的.sigma..sub.p值的电子吸引能力。包括与特定结合物共轭的化学发光标记组合物；包括该共轭物的化学发光测定和能够进行该测定的化学发光测定试剂盒。
• Assays utilizing improved chemiluminescent esters, thioesters and amides
  申请人：LONDON DIAGNOSTICS, INC.

  公开号：EP0322926A2

  公开（公告）日：1989-07-05

  In accordance with the present invention, specific binding assays are disclosed which utilize an chemiluminescent compound, i.e., moiety, which has increased stability in aqueous solution. The chemiluminescent moiety is an ester, thioester or amide in which the ester, thioester or amide linkage is between (1) a heterocyclic ring or ring system containing a carbon atom to which the linkage is attached, wherein the heteroatom within the heterocyclic ring or ring system is in an oxidation state which renders such carbon atom susceptible to attack by peroxide or molecular oxygen to form an intermediate which decays to produce chemiluminescence, and (2) an aryl ring or ring system. The aryl ring or ring system contains at least one substituted six-member ring. The substituted six-member ring has two or more substituent groups, where at least two of said two or more substituent groups sterically hinder hydrolysis of said linkage. One or more of the substituent groups which sterically hinder hydrolysis of said linkage may be an electron withdrawing group. The substituted six-member ring may have one or more additional substituent groups in addition to the substituent groups which sterically hinder hydrolysis of the linkage. Such additional substituent groups may also be an electron withdrawing group. The carbon atoms in the heterocyclic ring or ring system, to which the linkage is attached, may also have a secondary substituent of the formula RnX-, where X is selected from the group consisting of O, N, S and C, where R is any group, and where n is a number such that X has proper valency. Other chemiluminescent moieties are disclosed which are characterized by a heterocyclic ring or ring system and a secondary substituent of the formula RnX-, with the ester, thioester or amide linkage being between the heterocyclic ring or ring system and a leaving group. The disclosed chemiluminescent moieties can also include substituents at peri positions within the heterocyclic ring or ring system. Also in accordance with the present invention, compositions including and assay kits incorporating such chemiluminescent moieties are disclosed.

  根据本发明，公开了利用化学发光化合物（即在水溶液中稳定性更强的分子）进行特异性结合测定的方法。化学发光分子是酯类、硫酯类或酰胺类，其中酯类、硫酯类或酰胺类连接在 (1) 杂环或环系之间，杂环或环系含有一个碳原子，连接在该碳原子上，杂环或环系中的杂原子处于氧化状态，使该碳原子易受过氧化物或分子氧的侵蚀而形成中间体，中间体衰变产生化学发光；(2) 芳环或环系。芳基环或环系统包含至少一个取代的六元环。取代的六元环具有两个或两个以上的取代基，其中至少有两个取代基在立体上阻碍了所述连接的水解。其中一个或多个取代基团可以是取电子基团，这些取代基团立体地阻碍了所述连接的水解。取代的六元环除了具有立体阻碍水解连接的取代基团外，还可以具有一个或多个额外的取代基团。这些额外的取代基团也可以是取电子基团。 连接该连接体的杂环或环系中的碳原子也可以具有式 RnX- 的仲取代基，其中 X 选自 O、N、S 和 C 组成的组，R 为任意基团，n 为使 X 具有适当价数的数字。还公开了其他化学发光分子，其特征在于杂环或环系和式 RnX- 的仲取代基，酯、硫酯或酰胺连接在杂环或环系和离去基团之间。所公开的化学发光分子还可以包括杂环或环系周围位置的取代基。 根据本发明，还公开了包含此类化学发光分子的组合物和检测试剂盒。
• US5284951A
  申请人：——

  公开号：US5284951A

  公开（公告）日：1994-02-08
• US5290936A
  申请人：——

  公开号：US5290936A

  公开（公告）日：1994-03-01