1-<2-<2-hydroxy-3-(1-piperidyl)propoxy>phenyl>ethanone | 163858-61-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-<2-<2-hydroxy-3-(1-piperidyl)propoxy>phenyl>ethanone
• 英文别名: 1-[2-(2-hydroxy-3-piperidino-propoxy)-phenyl]-ethanone；1-[2-(2-Hydroxy-3-piperidino-propoxy)-phenyl]-aethanon；1-[2-(2-Hydroxy-3-piperidin-1-ylpropoxy)phenyl]ethanone
• CAS: 163858-61-5
• 化学式: C₁₆H₂₃NO₃
• 分子量: 277.364
• InChiKey: CKFCUQCADGWOMJ-UHFFFAOYSA-N

物化性质

• 沸点：
  448.3±35.0 °C(Predicted)
• 密度：
  1.112±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  49.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2'-羟基苯乙酮 在 alkaline solution 、 Petroleum ether 作用下， 生成 1-<2-<2-hydroxy-3-(1-piperidyl)propoxy>phenyl>ethanone
  参考文献：
  名称：

  Beasley et al., Journal of Pharmacy and Pharmacology, 1958, vol. 10, p. 47,59

  摘要：

  DOI：

文献信息

• Beasley et al., Journal of Pharmacy and Pharmacology, 1958, vol. 10, p. 47,59
  作者：Beasley et al.

  DOI：——

  日期：——
• Synthesis, Pharmacologic Activity, and Structure-Activity Relationships of a Series of Propafenone-Related Modulators of Multidrug Resistance
  作者：Peter Chiba、Sabine Burghofer、Elisabeth Richter、Barbara Tell、Andrea Moser、Gerhard Ecker

  DOI：10.1021/jm00014a031

  日期：1995.7

  A series of [(o-acylaryl)oxy]propanolamines have been prepared and evaluated for multidrug resistance-reverting activity in a human tumor cell model. Structure-activity relationship studies indicate that the phenylpropiophenone moiety as well as the substitution pattern at the nitrogen atom is crucial for activity of the compounds. Incorporation of the ether oxygen into a benzofuran substructure, which renders the compound an arylethanolamine, decreased biologic activity. Highest activity could be observed with the arylpiparazines 4f-h, which not only completely restored daunomycin sensitivity but also showed moderate activity in restoring etoposide toxicity.