Uracil, 5-bromo-3-sec-butyl-1,6-dimethyl- | 7692-45-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: Uracil, 5-bromo-3-sec-butyl-1,6-dimethyl-
• 英文别名: 5-bromo-3-butan-2-yl-1,6-dimethylpyrimidine-2,4-dione
• CAS: 7692-45-7
• 化学式: C₁₀H₁₅BrN₂O₂
• 分子量: 275.14
• InChiKey: UBPNZFXNWCPPTK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  40.6
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Agricultural sulfonamides, and preparation and use thereof
  申请人：E.I. DU PONT DE NEMOURS AND COMPANY

  公开号：EP0009419A1

  公开（公告）日：1980-04-02

  A compound or an agricuituraity suitable salt thereof, which has the general formula wherein R is thienyl or mono- or disubstituted phenyl; R, and R2 are independently H or CH3; W isOorS; X is CH3 or-OCH3; Y is selected from a variety of organic and inorganic substituents; and Z is CH or N; is of interest for the regulation of plant growth and as a pre-emergence or post-emergence herbicide. The compound can be made e.g. by reacting an appropriate sulfonyl isocyanate or isothiocyanate with an appropriate 2-aminopyrimidine- or 2 amino-1,3,5-triazine: The compound can be formulated for use in conventional manner and applied to the locus of vegetation to be controlled.

  一种化合物或其农业适用盐，其通式为 其中 R 是噻吩基或单取代或二取代苯基； R 和 R2 独立地为 H 或 CH3； W是O或S； X 是 或-O ； Y 选自各种有机和无机取代基；以及 Z 是 CH 或 N； 对调节植物生长和作为芽前或芽后除草剂具有重要意义。该化合物可通过适当的磺酰异氰酸酯或异硫氰酸酯与适当的 2-氨基嘧啶或 2-氨基-1,3,5-三嗪反应制成：该化合物可按常规方法配制使用，并施用到需要控制的植被部位。
• PHOSPHOLIPID ETHER (PLE) CAR T CELL TUMOR TARGETING (CTCT) AGENTS
  申请人：Seattle Children's Hospital (dba Seattle Children's Research Institute)

  公开号：US20200087399A1

  公开（公告）日：2020-03-19

  Aspects of the invention described herein relate to synthetic compounds that are useful for targeting and labeling tumor cells so as to facilitate recognition by binding agents including Chimeric Antigen Receptor T cells (CAR T cells), which are administered to a subject by intravenous or locoregional administration. Several compositions and methods of making and using these compositions to treat or inhibit a disease in a subject are contemplated.
• METHODS AND COMPOSITIONS FOR STIMULATION OF CHIMERIC ANTIGEN RECEPTOR T CELLS WITH HAPTEN LABELLED CELLS
  申请人：Seattle Children's Hospital (dba Seattle Children's Research Institute)

  公开号：US20210317407A1

  公开（公告）日：2021-10-14

  Some embodiments of the methods and compositions provided herein relate to the use of hapten labeled cells to stimulate chimeric antigen receptor (CAR) T cells. In some embodiments, CAR T cells can include a CAR that specifically binds to a hapten. Some embodiments relate to the in vivo or in vitro stimulation CAR T cells by hapten labeled cells.
• [EN] PHOSPHOLIPID ETHER (PLE) CAR T CELL TUMOR TARGETING (CTCT) AGENTS<br/>[FR] AGENTS DE CIBLAGE DE TUMEUR À LYMPHOCYTES T CAR (CTCT) D'ÉTHER DE PHOSPHOLIPIDE (PLE)
  申请人：SEATTLE CHILDRENS HOSPITAL DBA SEATTLE CHILDRENS RES INST

  公开号：WO2018148224A1

  公开（公告）日：2018-08-16

  Aspects of the invention described herein relate to synthetic compounds that are useful for targeting and labeling tumor cells so as to facilitate recognition by binding agents including Chimeric Antigen Receptor T cells (CAR T cells), which are administered to a subject by intravenous or locoregional administration. Several compositions and methods of making and using these compositions to treat or inhibit a disease in a subject are contemplated.