(2-巯乙基)环己烷硫醇 | 27214-61-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: (2-巯乙基)环己烷硫醇
• 英文名称: 1-O-(D-glucopyranosyl)ethylene glycol
• 英文别名: glycol-mono-glucoside；ethylene glycol glucoside；2-Hydroxyethyl D-glucoside；(3R,4S,5S,6R)-2-(2-hydroxyethoxy)-6-(hydroxymethyl)oxane-3,4,5-triol
• CAS: 27214-61-5
• 化学式: C₈H₁₆O₇
• 分子量: 224.211
• InChiKey: SMORULFPMBCEPX-KEWYIRBNSA-N

物化性质

• 沸点：
  490.8±45.0 °C(Predicted)
• 密度：
  1.53±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -2.9
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  120
• 氢给体数：
  5
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  (2-巯乙基)环己烷硫醇 在 吡啶 、 三乙基硅烷 、 iron(III) chloride hexahydrate 、 sodium methylate 作用下， 以 甲醇 、 乙腈 为溶剂， 反应 15.0h， 生成 2-(benzyloxy)ethyl 3-O-benzyl-4,6-O-benzylidene-α-D-glucopyranoside
  参考文献：
  名称：

  催化氯化铁（III）介导的单糖，双糖和一种三糖的位点选择性保护

  摘要：

  单糖和寡糖底物的羟基的区域选择性分化对于形成可用于合成转化的结构单元是必需的。在本文中，我们表明六水合氯化铁（III）可以催化一糖和二糖的串联保护，从而在一锅法中提供选择性保护的糖类结构单元。该串联方案已成功应用于三糖。该程序易于执行；为了获得最佳结果，每种碳水化合物底物都需要对一锅反应条件进行微调。

  DOI：

  10.1002/ejoc.201700538
• 作为产物：
  描述：

  D-葡萄糖 、 乙二醇 在 Dowex 50WX 作用下， 生成 (2-巯乙基)环己烷硫醇
  参考文献：
  名称：

  Para-hydrogenated Glucose Derivatives as Potential ¹³C-Hyperpolarized Probes for Magnetic Resonance Imaging

  摘要：

  A set of molecules in which a glucose moiety is bound to a hydrogenable synthon has been synthesized and evaluated for hydrogenation reactions and for the corresponding para-hydrogen-induced polarization (PHIP) effects, in order to select suitable candidates for an in vivo magnetic resonance imaging (MRI) method for the assessment of glucose cellular uptake. It has been found that amidic derivatives do not yield any polarization enhancement, probably due to singlet-triplet state mixing along the reaction pathway. In contrast, ester derivatives are hydrogenated in high yield and afford enhanced H-1 and C-13 NMR spectra after para-hydrogenation. The obtained PHIP patterns are discussed and explained on the basis of the calculated spin level populations in the para-hydrogenated products. These molecules may find interesting applications in C-13 MRI as hyperpolarized probes for assessing the activity of glucose transporters in cells.

  DOI：

  10.1021/ja101399q

文献信息

• [EN] SYNTHESIS AND USE OF GLYCOSIDE PRO-DRUG ANALOGS<br/>[FR] SYNTHÈSE ET UTILISATION D'ANALOGUES GLYCOSIDES DE PROMÉDICAMENT
  申请人：NUTEK PHARMA LTD

  公开号：WO2012142141A1

  公开（公告）日：2012-10-18

  The present invention relates to methods and compositions for the synthesis, production, and use of pro-drug analogs. This invention relates to a method for the production of a broad group of glycosylated drugs, including but not limited to propofol, acetaminophen, and camptothecin carbohydrate derivatives.

  本发明涉及用于合成、生产和使用前药类似物的方法和组合物。本发明涉及一种用于生产包括但不限于丙泊酚、对乙酰氨基酚和喜树碱糖衍生物在内的广泛群体的糖基药物的方法。
• Sulfonium salt compound and resist composition and pattern forming method using the same
  申请人：NEC CORPORATION

  公开号：US20020045122A1

  公开（公告）日：2002-04-18

  The present invention relates to a photo acid generator which has high transparency to exposure light and also has excellent heat stability in a photoresist composition for lithography using far ultraviolet light, especially light of ArF excimer laser. The photo acid generator contains a sulfonium salt compound represented by the following general formula (1): 1 wherein R 1 represents an alkylene group, or an alkylene group having an oxo group, R 2 represents a straight-chain, branched-chain, monocyclic, polycyclic or bridged cyclic alkyl group having an oxo group, or a straight-chain, branched-chain, monocyclic, polycyclic or bridged cyclic alkyl group, provided that either of R 1 and R 2 has an oxo group, and Y − represents a counter ion.

  本发明涉及一种具有对紫外线透明度高并且在使用远紫外光（尤其是ArF准分子激光）的光刻用光阻组合物中具有优异的热稳定性的光酸发生剂。该光酸发生剂包含下式（1）所表示的烷基硫鎓盐化合物：其中，R1表示烷基，或者具有氧代基的烷基，R2表示具有氧代基的直链、支链、单环、多环或桥环烷基，或者直链、支链、单环、多环或桥环烷基，只要R1和R2中的任意一个具有氧代基，Y-表示反离子。
• Fluid, stable interpolymer/polyol compositions, process for the production thereof and processes for the production of elastomeric polyurethanes and polyurethane foams therefrom
  申请人：UNION CARBIDE CORPORATION

  公开号：EP0006605A1

  公开（公告）日：1980-01-09

  Fluid, stable polymer-polyols are provided which consist of an organic polyol medium and an interpolymer of a minor amount of polymerized ethylenically unsaturated dicarboxylic acid anhydride, such as maleic acid anhydride, and a major amount of at least one different polymerized ethylenically unsaturated monomer, the interpolymer being in the form of particles that are stably dispersed in the polyol. Polyurethane foams produced from these polymer/ polyols display improved load bearing and compression set when compared with polymer/polyols produced in a similar manner without the ethylenically unsaturated dicarboxylic acid anhydride: elastomers so produced have improved tensile modulus and tear properties.

  提供了流体稳定聚合物多元醇，它由有机多元醇介质和少量聚合乙烯基不饱和二羧酸酐（如马来酸酐）与大量至少一种不同的聚合乙烯基不饱和单体的互聚物组成，互聚物呈颗粒状稳定地分散在多元醇中。与不含乙烯基不饱和二羧酸酐的聚合物/多元醇相比，用这些聚合物/多元醇生产的聚氨酯泡沫塑料的承载能力和压缩永久变形都有所改善：用这种方法生产的弹性体具有更好的拉伸模量和撕裂性能。
• Preparation of polyoxyalkylene surfactants for the stabilisation of phenolic foam, optionally in the presence of a metal catalyst
  申请人：Celotex Corporation

  公开号：EP0039756A2

  公开（公告）日：1981-11-18

  Polyoxyalkylene surfactants for cellular foams can be prepared by reacting under free radical polymerization conditions a polyoxyalkylene adduct, a cyclic nitrogenous vinyl monomer and an esterified unsaturated dibasic acid in the presence of an organic or inorganic per-compound and a metal catalyst.

  用于蜂窝泡沫的聚氧亚烷基表面活性剂可以通过在自由基聚合条件下，在有机或无机过化合物和金属催化剂的存在下，使聚氧亚烷基加合物、环状含氮乙烯基单体和酯化不饱和二元酸发生反应来制备。
• Process for the production of polymer/polyisocyanate compositions and the use thereof for making polyurethanes
  申请人：UNION CARBIDE CORPORATION

  公开号：EP0037112A1

  公开（公告）日：1981-10-07

  Novel improved polymer/polyisocyanate composition made by polymerizing acrylonitrile alone or with one or more ethylenically unsaturated monomers in situ in a polyisocyanate. The polyisocyanate comprises a diarylalkylene diisocyanate; a polymeric diarylalkylene polyisocyanate; a quasi-prepolymer of a diarylalkylene diisocyanate or a polymeric diarylalkylene diisocyanate with an active hydrogen organic compound having at least two active hydrogen atoms per molecule; a mixture of a diarylalkylene diisocyanate, its carbodiimide and its trifunctional trimenc cycloadduct; or a mixture of two or more such polyisocyanates. to form a highly stable dispersion of small polymer particles in said polyisocyanate. The novel compositions are highly useful in the production of polyurethane products.

  新型改良聚合物/多异氰酸酯组合物，由丙烯腈单独或与一种或多种乙烯基不饱和单体在多异氰酸酯中原位聚合而成。多异氰酸酯包括二芳基烷烃二异氰酸酯；聚合二芳基烷烃多异氰酸酯；二芳基烷烃二异氰酸酯或聚合二芳基烷烃二异氰酸酯与每分子至少有两个活性氢原子的活性氢有机化合物的准预聚物；二芳基烷烃二异氰酸酯、其碳二亚胺和其三官能三缩环加合物的混合物；或 两种或两种以上此类多异氰酸酯的混合物。使小聚合物颗粒在所述多异氰酸酯中形成高度稳定的分散体。这种新型组合物在生产聚氨酯产品时非常有用。