O-(正丁基)膦酸钠 | 56317-58-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: O-(正丁基)膦酸钠
• 英文名称: sodium O-(n-butyl) phosphonate
• 英文别名: b-butyl sodium phosphite；phosphonic acid monobutyl ester; sodium salt；phosphorous acid monobutyl ester; sodium salt；Phosphonsaeure-monobutylester; Natriumsalz
• CAS: 56317-58-9
• 化学式: C₄H₁₀O₃P*Na
• 分子量: 160.085
• InChiKey: AXFYZJFIISYITQ-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -2.44
• 重原子数：
  9.0
• 可旋转键数：
  4.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  49.36
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  O-(正丁基)膦酸钠 、 环己醇 生成 O-Butyl-O-cyclohexyl-phosphit
  参考文献：
  名称：

  Michalski,J.; Zwierzak,A., Roczniki Chemii, 1962, vol. 36, p. 97 - 102

  摘要：

  DOI：
• 作为产物：
  描述：

  亚磷酸二丁酯 在 sodium hydroxide 作用下， 生成 O-(正丁基)膦酸钠
  参考文献：
  名称：

  Nylen, Svensk Kemisk Tidskrift, vol. 48, p. 2,6

  摘要：

  DOI：

文献信息

• Synthesis of esters of phosphonoformic acid and their antiherpes activity
  作者：Jan O. Noren、Erik Helgstrand、Nils G. Johansson、Alfons Misiorny、Goeran Stening

  DOI：10.1021/jm00356a028

  日期：1983.2

  Aliphatic and aromatic mono-, di-, and triesters of phosphonoformic acid (foscarnet) were synthesized. The triesters were prepared by the Michaelis-Arbuzov reaction and were hydrolyzed to di- and monoesters. The compounds were tested for antiviral activity on isolated herpes simplex virus type 1 (HSV-1) DNA polymerase, in a HSV-1 plaque reduction assay, and on a cutaneous HSV-1 infection in guinea pigs. None of the esters inhibited the activity of isolated HSV-1 polymerases. Monoesters with a free carboxylic group and diesters with an aromatic carboxylic ester function were active against the cutaneous herpes infection. Mono- and diesters with an aromatic phosphonic ester group also showed activity in the plaque-reduction assay. However, mono- and diesters with an aromatic phosphonic ester group also showed activity in the plaque-reduction assay. However, mono- and diesters with aliphatic carboxylic ester groups were inactive in all test systems. The results show that all three acidic groups of phosphonoformic acid must be free in order to get antiviral activity at the enzyme level. However, certain esters of this acid may be biotransformed to the acid itself to give antiherpes activity.
• Brazier,J.-F. et al., Bulletin de la Societe Chimique de France, 1970, p. 1089 - 1094
  作者：Brazier,J.-F. et al.

  DOI：——

  日期：——
• Singh, O. P.; Mehrotra, R. K.; Srivastava, G., Synthesis and Reactivity in Inorganic and Metal-Organic Chemistry, 1991, vol. 21, p. 717 - 728
  作者：Singh, O. P.、Mehrotra, R. K.、Srivastava, G.

  DOI：——

  日期：——
• NOREN, J. O.;HELGSTRAND, E.;JOHANSSON, N. G.;MISIORNY, A.;STENING, G., J. MED. CHEM., 1983, 26, N 2, 264-270
  作者：NOREN, J. O.、HELGSTRAND, E.、JOHANSSON, N. G.、MISIORNY, A.、STENING, G.

  DOI：——

  日期：——