(2S,3R,4S,5S,6R)-2-pent-4-enoxy-2-[[(2S,3R,4S,5S,6R)-2-[[(2S,3R,4S,5S,6R)-2-(pent-4-enoxymethyl)-3,4,5-tris(phenylmethoxy)-6-(phenylmethoxymethyl)oxan-2-yl]oxymethyl]-3,4,5-tris(phenylmethoxy)-6-(phenylmethoxymethyl)oxan-2-yl]oxymethyl]-3,4,5-tris(phenylmethoxy)-6-(phenylmethoxymethyl)oxane | 1170693-06-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2S,3R,4S,5S,6R)-2-pent-4-enoxy-2-[[(2S,3R,4S,5S,6R)-2-[[(2S,3R,4S,5S,6R)-2-(pent-4-enoxymethyl)-3,4,5-tris(phenylmethoxy)-6-(phenylmethoxymethyl)oxan-2-yl]oxymethyl]-3,4,5-tris(phenylmethoxy)-6-(phenylmethoxymethyl)oxan-2-yl]oxymethyl]-3,4,5-tris(phenylmethoxy)-6-(phenylmethoxymethyl)oxane
• CAS: 1170693-06-7
• 化学式: C₁₁₅H₁₂₆O₁₉
• 分子量: 1812.25
• InChiKey: TZYKQNAMWZPOMT-PDGHHBKASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  18.3
• 重原子数：
  134
• 可旋转键数：
  56
• 环数：
  15.0
• sp3杂化的碳原子比例：
  0.34
• 拓扑面积：
  175
• 氢给体数：
  0
• 氢受体数：
  19

反应信息

• 作为反应物：
  描述：

  (2S,3R,4S,5S,6R)-2-pent-4-enoxy-2-[[(2S,3R,4S,5S,6R)-2-[[(2S,3R,4S,5S,6R)-2-(pent-4-enoxymethyl)-3,4,5-tris(phenylmethoxy)-6-(phenylmethoxymethyl)oxan-2-yl]oxymethyl]-3,4,5-tris(phenylmethoxy)-6-(phenylmethoxymethyl)oxan-2-yl]oxymethyl]-3,4,5-tris(phenylmethoxy)-6-(phenylmethoxymethyl)oxane 在 RuCl2(1,3-dimesityl-imidazolidin-2-yl)(PCy3)(=CHPh) 作用下， 以 四氯化碳 为溶剂， 反应 3.0h， 生成
  参考文献：
  名称：

  Transformation of linear oligoketosides into macrocyclic neoglycoconjugates

  摘要：

  The macrocyclization of linear D-galacto-2-heptulopyranose-containing oligoketosides has been carried out by intramolecular glycosidation and ring-closing metathesis. The aglycon fragment of the cyclic neglycoconjugates thus formed was an alkylidene or a polyether chain. One of the oligoketoside-crown ethers showed a moderate asymmetric induction in the Cram model phenyl acetate-acrylate addition. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.03.056
• 作为产物：
  描述：

  5-溴-1-戊烯 、 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以77%的产率得到(2S,3R,4S,5S,6R)-2-pent-4-enoxy-2-[[(2S,3R,4S,5S,6R)-2-[[(2S,3R,4S,5S,6R)-2-(pent-4-enoxymethyl)-3,4,5-tris(phenylmethoxy)-6-(phenylmethoxymethyl)oxan-2-yl]oxymethyl]-3,4,5-tris(phenylmethoxy)-6-(phenylmethoxymethyl)oxan-2-yl]oxymethyl]-3,4,5-tris(phenylmethoxy)-6-(phenylmethoxymethyl)oxane
  参考文献：
  名称：

  Transformation of linear oligoketosides into macrocyclic neoglycoconjugates

  摘要：

  The macrocyclization of linear D-galacto-2-heptulopyranose-containing oligoketosides has been carried out by intramolecular glycosidation and ring-closing metathesis. The aglycon fragment of the cyclic neglycoconjugates thus formed was an alkylidene or a polyether chain. One of the oligoketoside-crown ethers showed a moderate asymmetric induction in the Cram model phenyl acetate-acrylate addition. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.03.056

文献信息

• Transformation of linear oligoketosides into macrocyclic neoglycoconjugates
  作者：Alessandro Dondoni、Alberto Marra

  DOI：10.1016/j.tetlet.2009.03.056

  日期：2009.7

  The macrocyclization of linear D-galacto-2-heptulopyranose-containing oligoketosides has been carried out by intramolecular glycosidation and ring-closing metathesis. The aglycon fragment of the cyclic neglycoconjugates thus formed was an alkylidene or a polyether chain. One of the oligoketoside-crown ethers showed a moderate asymmetric induction in the Cram model phenyl acetate-acrylate addition. (C) 2009 Elsevier Ltd. All rights reserved.