1-(4-acetylphenyl)cycloheptene | 27676-28-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(4-acetylphenyl)cycloheptene
• 英文别名: p-(1-Cycloheptenyl)-acetophenon；para-(1-cycloheptenyl)-acetophenone；p-(cyclohepten-1-yl)-acetophenone；1-[4-(cyclohepten-1-yl)phenyl]ethanone
• CAS: 27676-28-4
• 化学式: C₁₅H₁₈O
• 分子量: 214.307
• InChiKey: ZWVZHFHVKUHCMH-UHFFFAOYSA-N

物化性质

• 沸点：
  140 °C(Press: 0.04 Torr)
• 密度：
  1.014±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-(4-acetylphenyl)cycloheptene 在 溴 、 silica gel 作用下， 以 二氯甲烷 为溶剂， 反应 74.0h， 生成 1-(4-acetylphenyl)-6-bromocycloheptene
  参考文献：
  名称：

  Auto de-bromine-coupling reactions of 1-aryl-7-bromocycloheptenes

  摘要：

  Auto de-bromine-coupling reactions of 1-aryl-7-bromocycloheptenes to a new series of [7-6-6] tricyclic system were described. A variety of substituents at the para-position of the phenyl were amenable to this transformation, including electron-donating groups and halides. The presence of electron-donating groups resulted in a more efficient reaction, with higher yields than the case of halides. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2014.03.023
• 作为产物：
  描述：

  4-溴苯乙酮 在 碘 、 对甲苯磺酸 、 magnesium 作用下， 以 乙醚 、 正己烷 为溶剂， 反应 14.0h， 生成 1-(4-acetylphenyl)cycloheptene
  参考文献：
  名称：

  Auto de-bromine-coupling reactions of 1-aryl-7-bromocycloheptenes

  摘要：

  Auto de-bromine-coupling reactions of 1-aryl-7-bromocycloheptenes to a new series of [7-6-6] tricyclic system were described. A variety of substituents at the para-position of the phenyl were amenable to this transformation, including electron-donating groups and halides. The presence of electron-donating groups resulted in a more efficient reaction, with higher yields than the case of halides. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2014.03.023

文献信息

• Heck reaction of aryl halides with linear or cyclic alkenes catalysed by a tetraphosphine/palladium catalyst
  作者：Florian Berthiol、Henri Doucet、Maurice Santelli

  DOI：10.1016/s0040-4039(02)02788-0

  日期：2003.2

  4-Tetrakis(diphenylphosphinomethyl)cyclopentane/[PdCl(C3H5)]2 system catalyses efficiently the Heck reaction of aryl halides with linear alkenes such as pent-1-ene, oct-1-ene or dec-1-ene. Selectivities up to 70% in favour of E-1-arylalk-1-ene isomers can be obtained. In the presence of cyclic alkenes the selectivities of the reactions strongly depends on the ring size. Addition to cyclohexene or cycloheptene led mainly

  cis，cis，cis -1,2,3,4-Tetrakis（diphenylphosphinomethyl）cyclopentane / [PdCl（C 3 H 5）] 2体系有效地催化芳基卤化物与线性烯烃（如戊-1-烯）的Heck反应，辛-1-烯或癸-1-烯。选择性高达赞成70％Ë -1- arylalk -1-烯异构体可制得。在环状烯烃的存在下，反应的选择性很大程度上取决于环的大小。除环己烯或环庚烯外，主要产生1-芳基环烷-3-烯衍生物。另一方面，除环辛烯外，还生成了1-芳基环烷-1-烯加合物。
• .alpha.-Cycloalkenylphenyl-fatty acid nitriles
  申请人：Ciba-Geigy Corporation

  公开号：US03944589A1

  公开（公告）日：1976-03-16

  Compounds of the formula ##EQU1## in which X represents a free carboxyl group or in the second place an esterified or amidated carboxyl group; R represents a 1-cycloalkenyl residue; Ph represents an ortho-phenylene residue or especially a para-phenylene residue; and R.sub.1 and R.sub.2 each represents a hydrogen atom or a monovalent or together a divalent aliphatic or araliphatic hydrocarbon residue, e.g. the .alpha.-[p-(1-cyclohexenyl)-phenyl]-propionic acid, are useful as analgetic and antiinflammatoric agents.

  式子为##EQU1##的化合物中，X代表自由羧基或第二位酯化或酰胺化的羧基；R代表1-环烯基残基；Ph代表邻苯基残基或尤其是对苯基残基；R.sub.1和R.sub.2各代表氢原子或一价或共价的脂肪族或芳基脂肪族碳氢残基，例如α-[p-(1-环己烯基)-苯基]-丙酸可用作镇痛和抗炎药物。
• US3940434A
  申请人：——

  公开号：US3940434A

  公开（公告）日：1976-02-24
• US3944589A
  申请人：——

  公开号：US3944589A

  公开（公告）日：1976-03-16
• US4004026A
  申请人：——

  公开号：US4004026A

  公开（公告）日：1977-01-18