1-methyl-2-[4-((S)-tetrahydrofuran-3-yloxy)-benzyl]-4-(β-D-glucopyranos-1-yl)-benzene | 892486-47-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-methyl-2-[4-((S)-tetrahydrofuran-3-yloxy)-benzyl]-4-(β-D-glucopyranos-1-yl)-benzene
• 英文别名: (2R,3S,4R,5R,6S)-2-(hydroxymethyl)-6-[4-methyl-3-[[4-[(3S)-oxolan-3-yl]oxyphenyl]methyl]phenyl]oxane-3,4,5-triol
• CAS: 892486-47-4
• 化学式: C₂₄H₃₀O₇
• 分子量: 430.498
• InChiKey: GLGHFXKHVNORIQ-GMKBEQEGSA-N

物化性质

• 沸点：
  658.5±55.0 °C(Predicted)
• 密度：
  1.317±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  31
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  109
• 氢给体数：
  4
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  1-methyl-4-(β-D-glucopyranos-1-yl)-2-(4-hydroxy-benzyl)-benzene 、 (R)-3-羟基四氢呋喃对甲苯磺酸酯 在 caesium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 22.0h， 以46%的产率得到1-methyl-2-[4-((S)-tetrahydrofuran-3-yloxy)-benzyl]-4-(β-D-glucopyranos-1-yl)-benzene
  参考文献：
  名称：

  WO2008/49923

  摘要：

  公开号：

文献信息

• PHARMACEUTICAL COMPOSITION COMPRISING A GLUCOPYRANOSYL-SUBSTITUTED BENZENE DERIVATIVE
  申请人：Boehringer Ingelheim International GmbH

  公开号：EP3939577A1

  公开（公告）日：2022-01-19

  The invention relates to a pharmaceutical composition according to the claim 1 comprising a glucopyranosyl-substituted benzene derivative in combination with a DPP IV inhibitor which is suitable in the treatment or prevention of one or more conditions selected from type 1 diabetes mellitus, type 2 diabetes mellitus, impaired glucose tolerance and hyperglycemia. In addition the present invention relates to methods for preventing or treating of metabolic disorders and related conditions.

  该发明涉及根据权利要求1的药物组合物，包括一种葡萄糖吡喃基取代苯衍生物与一种适用于治疗或预防从以下选定的一种或多种疾病的DPP IV抑制剂的组合物，所述疾病包括1型糖尿病、2型糖尿病、糖耐量受损和高血糖。此外，本发明涉及预防或治疗代谢紊乱及相关疾病的方法。
• GLUCOPYRANOSYL-SUBSTITUTED PHENYL DERIVATIVES, MEDICAMENTS CONTAINING SUCH COMPOUNDS, THEIR USE AND PROCESS FOR THEIR MANUFACTURE
  申请人：ECKHARDT Matthias

  公开号：US20120296080A1

  公开（公告）日：2012-11-22

  Glucopyranosyl-substituted benzene derivatives of general formula I where the groups R 1 to R 6 as well as R 7a , R 7b , R 7c are defined herein and the tautomers, the stereoisomers thereof, the mixtures thereof and the salts thereof. The compounds according to the invention are suitable for the treatment of metabolic disorders.

  本发明涉及一般式I的葡萄糖吡喃糖苷取代苯衍生物，其中所述基团R1至R6以及R7a、R7b、R7c的定义如本文所述，以及其互变异构体、立体异构体、混合物和盐。本发明的化合物适用于治疗代谢紊乱。
• GLUCOPYRANOSYL-SUBSTITUTED PHENYL DERIVATES, MEDICAMENTS CONTAINING SUCH COMPOUNDS, THEIR USE AND PROCESS FOR THEIR MANUFACTURE
  申请人：ECKHARDT Matthias

  公开号：US20140046046A1

  公开（公告）日：2014-02-13

  Glucopyranosyl-substituted benzene derivatives of general formula I where the groups R 1 to R 6 as well as R 7a , R 7b , R 7c are defined herein and the tautomers, the stereoisomers thereof, the mixtures thereof and the salts thereof. The compounds according to the invention are suitable for the treatment of metabolic disorders.

  本发明提供了一般式I的葡萄糖吡喃取代苯衍生物，其中基团R1至R6以及R7a、R7b、R7c在此定义，以及其互变异构体、立体异构体、混合物和盐。本发明的化合物适用于治疗代谢紊乱。
• Glucopyranosyl-substituted benzene derivatives, medicaments containing such compounds, their use and process for their manufacture
  申请人：Eckhardt Matthias

  公开号：US20060142210A1

  公开（公告）日：2006-06-29

  Glucopyranosyl-substituted benzene derivatives defined according to claim 1, including the tautomers, the stereoisomers thereof, the mixtures thereof and the salts thereof. The compounds according to the invention are suitable for the treatment of metabolic disorders.

  根据权利要求1定义的葡萄糖吡喃基取代的苯衍生物，包括其互变异构体、立体异构体、混合物和盐。本发明的化合物适用于治疗代谢性疾病。
• PHARMACEUTICAL COMPOSITION COMPRISING A GLUCOPYRANOSYL-SUBSTITUTED BENZENE DERIVATE
  申请人：Dugi Klaus

  公开号：US20110195917A1

  公开（公告）日：2011-08-11

  The invention relates to a pharmaceutical composition according to the claim 1 comprising a glucopyranosyl-substituted benzene derivative in combination with a DPP IV inhibitor which is suitable in the treatment or prevention of one or more conditions selected from type 1 diabetes mellitus, type 2 diabetes mellitus, impaired glucose tolerance and hyperglycemia. In addition the present invention relates to methods for preventing or treating of metabolic disorders and related conditions.

  该发明涉及一种药物组合物，根据权利要求1，包括一种葡萄糖吡喃基取代的苯衍生物和一种适用于治疗或预防从以下选择的一种或多种疾病的DPP IV抑制剂：1型糖尿病，2型糖尿病，糖耐量受损和高血糖。此外，本发明还涉及预防或治疗代谢紊乱和相关疾病的方法。