(S)-3-[1-(tert-butyldimethylsilyloxy)ethyl]-2,2,2-trifluoroacetophenone | 871841-07-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (S)-3-[1-(tert-butyldimethylsilyloxy)ethyl]-2,2,2-trifluoroacetophenone
• CAS: 871841-07-5
• 化学式: C₁₆H₂₃F₃O₂Si
• 分子量: 332.438
• InChiKey: GDWIEGAHEXKVSX-NSHDSACASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.51
• 重原子数：
  22.0
• 可旋转键数：
  4.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  26.3
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  (S)-3-[1-(tert-butyldimethylsilyloxy)ethyl]-2,2,2-trifluoroacetophenone 在 吡啶 、 盐酸羟胺 作用下， 以 乙醇 为溶剂， 反应 4.0h， 以99%的产率得到(S)-3-[1-(tert-butyldimethylsilyloxy)ethyl]-2,2,2-trifluoroacetophenone oxime
  参考文献：
  名称：

  Preparation of novel 3H-trifluoromethyldiazirine-based photoactivatable potassium channel antagonists

  摘要：

  The preparation of a series of photoactivatable precursors for use in photoaffinity labelling of potassium channels is described. 3H-Diazirine functionalities were incorporated into the previously described potassium channel antagonists 1-3. The ability to perform enantioselective reductions and Wittig reactions in the presence of 3H-diazirines was central to this work. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2005.09.007
• 作为产物：
  描述：

  (S)-3-溴-alpha-甲基苄醇 在 正丁基锂 、 15-冠醚-5 、 sodium hydride 作用下， 以 四氢呋喃 、 正己烷 、 二氯甲烷 为溶剂， 反应 3.42h， 生成 (S)-3-[1-(tert-butyldimethylsilyloxy)ethyl]-2,2,2-trifluoroacetophenone
  参考文献：
  名称：

  Preparation of novel 3H-trifluoromethyldiazirine-based photoactivatable potassium channel antagonists

  摘要：

  The preparation of a series of photoactivatable precursors for use in photoaffinity labelling of potassium channels is described. 3H-Diazirine functionalities were incorporated into the previously described potassium channel antagonists 1-3. The ability to perform enantioselective reductions and Wittig reactions in the presence of 3H-diazirines was central to this work. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2005.09.007

文献信息

• Preparation of novel 3H-trifluoromethyldiazirine-based photoactivatable potassium channel antagonists
  作者：John M. Sanderson、John B.C. Findlay、Colin W.G. Fishwick

  DOI：10.1016/j.tet.2005.09.007

  日期：2005.11

  The preparation of a series of photoactivatable precursors for use in photoaffinity labelling of potassium channels is described. 3H-Diazirine functionalities were incorporated into the previously described potassium channel antagonists 1-3. The ability to perform enantioselective reductions and Wittig reactions in the presence of 3H-diazirines was central to this work. (c) 2005 Elsevier Ltd. All rights reserved.