6-(4-溴苯氧基)吡啶-3-胺 | 77006-26-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 6-(4-溴苯氧基)吡啶-3-胺
• 英文名称: 6-(4-bromo-phenoxy)-pyridin-3-ylamine
• 英文别名: 6-(4-bromophenoxy)-3-aminopyridine；6-(4-Bromophenoxy)pyridin-3-amine
• CAS: 77006-26-9
• 化学式: C₁₁H₉BrN₂O
• 分子量: 265.109
• InChiKey: BQTGEPHGOSFJKZ-UHFFFAOYSA-N

物化性质

• 熔点：
  107 °C

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  48.1
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 危险品标志：
  Xi
• 安全说明：
  S26,S37/39
• 危险类别码：
  R36/37/38
• 海关编码：
  2933399090
• 危险性防范说明：
  P261,P264,P270,P271,P280,P301+P312,P302+P352,P304+P340,P305+P351+P338,P330,P332+P313,P337+P313,P362,P403+P233,P405,P501
• 危险性描述：
  H302,H315,H319,H335

SDS

Name:	6-(4-Bromophenoxy)pyridin-3-amine 97% Material Safety Data Sheet
Synonym:
CAS:	77006-26-9

Section 1 - Chemical Product MSDS Name:6-(4-Bromophenoxy)pyridin-3-amine 97% Material Safety Data Sheet
Synonym:

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Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS

CAS#	Chemical Name	content	EINECS#
77006-26-9	6-(4-Bromophenoxy)pyridin-3-amine	97%	unlisted

Hazard Symbols: XI
Risk Phrases: 36/37/38

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Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Irritating to eyes, respiratory system and skin.
Potential Health Effects
Eye:
Causes eye irritation.
Skin:
Causes skin irritation. May be harmful if absorbed through the skin.
Ingestion:
May cause irritation of the digestive tract. May be harmful if swallowed.
Inhalation:
Causes respiratory tract irritation.
Chronic:
Not available.

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Section 4 - FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes.
Ingestion:
Get medical aid. Wash mouth out with water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician:
Treat symptomatically and supportively.

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Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam.

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Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container.

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Section 7 - HANDLING and STORAGE
Handling:
Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Storage:
Store in a cool, dry place. Store in a tightly closed container.

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Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 77006-26-9: Personal Protective Equipment Eyes: Not available.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

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Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Solid
Color: Not available.
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 107 - 109 deg C
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C11H9BrN2O
Molecular Weight: 265.11

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Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Not available.
Conditions to Avoid:
Incompatible materials.
Incompatibilities with Other Materials:
Strong oxidizing agents.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, carbon dioxide, hydrogen bromide, bromine.
Hazardous Polymerization: Has not been reported.

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Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 77006-26-9 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
6-(4-Bromophenoxy)pyridin-3-amine - Not listed by ACGIH, IARC, or NTP.

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Section 12 - ECOLOGICAL INFORMATION

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Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

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Section 14 - TRANSPORT INFORMATION

IATA
No information available.
IMO
No information available.
RID/ADR
No information available.

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Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XI
Risk Phrases:
R 36/37/38 Irritating to eyes, respiratory system
and skin.
Safety Phrases:
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 37/39 Wear suitable gloves and eye/face
protection.
WGK (Water Danger/Protection)
CAS# 77006-26-9: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 77006-26-9 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 77006-26-9 is not listed on the TSCA inventory.
It is for research and development use only.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  2,6-二甲氧基苯甲酰异氰酸酯 、 6-(4-溴苯氧基)吡啶-3-胺 在 乙酸乙酯 、 乙醇 作用下， 以 乙酸乙酯 为溶剂， 反应 33.0h， 生成 N-[6-(4-bromo-phenoxy)-pyridin-3-ylcarbamoyl]-2,6-dimethoxy-benzamide
  参考文献：
  名称：

  1-Benzoyl-3-(aryloxy- or arylthiopyridinyl) urea compounds

  摘要：

  本发明涉及1-苯甲酰基-3-(芳氧基或芳硫基吡啶基)脲类化合物，可用作杀虫剂。

  公开号：

  US04264605A1
• 作为产物：
  描述：

  2-(4-bromophenoxy)-5-nitropyridine 在 二氧化铂 氢气 作用下， 以 甲醇 为溶剂， 23.0 ℃ 、45.96 MPa 条件下， 反应 1.0h， 以affording 6 g of 6-(4-bromo-phenoxy)-pyridin-3-ylamine的产率得到6-(4-溴苯氧基)吡啶-3-胺
  参考文献：
  名称：

  Spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors

  摘要：

  本发明涉及5-螺环嘧啶-2,4,6-三酮金属蛋白酶抑制剂，其化学式如下：其中“A”为规范中定义的5-7成员杂环，以及用于治疗炎症、癌症和其他疾病的药物组合物和方法。

  公开号：

  US06841671B2

文献信息

• 1-Benzoyl-3-pyridinyl ureas, their use as insecticides, their preparation and formulations containing them
  申请人：ELI LILLY AND COMPANY

  公开号：EP0008881A1

  公开（公告）日：1980-03-19

  Compounds of formula: wherein R1 is halogen or C1-3alkyl; R3 is C1-5 alkyl, C3.5 alkenyl containing no α,β-unsaturation, C1-5 haloalkyl, C4-8 cycloalkyl, C2.S alkoxyalkyl or is phenyl optionally substituted by halogen, C1-3 haloalkyl or haloalkoxy, C1-3 alkyl or methoxy; R4 and R6 are the same or different groups selected from hydrogen, halogen, methyl or methoxy; m and n are the same or different and can each represent 0 or 1; X is oxygen or sulfur; and the nitrogen to pyridine bond is at the 2- or 3-position of the pyridine ring; provided that: (A) both of R4 and R5 cannot be hydrogen and when one of R4 and R5 is hydrogen the other is chloro and R3 is phenyl substituted by a trifluoromethyl group; (B) when the nitrogen to pyridine bond is at the 2-position the R2-(CH2)n-R3 group is at the 5-position; and (C) when the nitrogen to pyridine bond is at the 3-position the R2-(CH2)nR3 group is at the 6-position; and the acid-addition salts or N-oxide thereof have been found useful as insecticides. The compounds are prepared by the reaction of a benzoyl isocyanate or isothiocyanate with an aminopyridine.

  式中的化合物 其中 R1 为卤素或 C1-3 烷基； R3 是 C1-5 烷基、不含 α、β-不饱和度的 C3.5 烯基、C1-5 卤代烷基、C4-8 环烷基、C2.S 烷氧基烷基或任选被卤素、C1-3 卤代烷基或卤代烷氧基、C1-3 烷基或甲氧基取代的苯基； R4 和 R6 是相同或不同的基团，选自氢、卤素、甲基或甲氧基； m 和 n 相同或不同，可分别代表 0 或 1； X 是氧或硫；以及 氮与吡啶的键位于吡啶环的 2 位或 3 位；条件是： (A) R4 和 R5 不能都是氢，当 R4 和 R5 中的一个是氢时，另一个是氯，R3 是被三氟甲基取代的苯基； (B) 当氮吡啶键位于 2 位时，R2-(CH2)n-R3 基团位于 5 位；以及 (C) 当氮与吡啶的键位于 3 位时，R2-(CH2)nR3 基团位于 6 位；其酸加成盐或 N-氧化物可用作杀虫剂。 这些化合物是通过异氰酸苯甲酰酯或异硫氰酸酯与氨基吡啶反应制备的。
• SPIRO-PYRIMIDINE-2,4,6-TRIONE METALLOPROTEINASE INHIBITORS
  申请人：Pfizer Products Inc.

  公开号：EP1332146A2

  公开（公告）日：2003-08-06
• US4264605A
  申请人：——

  公开号：US4264605A

  公开（公告）日：1981-04-28
• US6841671B2
  申请人：——

  公开号：US6841671B2

  公开（公告）日：2005-01-11
• [EN] SPIRO-PYRIMIDINE-2,4,6-TRIONE METALLOPROTEINASE INHIBITORS<br/>[FR] INHIBITEURS DE METALLOPROTEINASE SPIRO-PYRIMIDINE-2,4,6-TRIONE
  申请人：PFIZER PROD INC

  公开号：WO2002034753A2

  公开（公告）日：2002-05-02

  The present invention relates to 5-spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors of the formula wherein said 'A' is a 5-7 membered heterocyclic ring as defined in the specification and to pharmaceutical compositions and methods of treating inflammation, cancer and othter disorders.