1,3-bis-(1-methylethoxy)-2-(trifluoromethyl)-2-propanol | 156572-66-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1,3-bis-(1-methylethoxy)-2-(trifluoromethyl)-2-propanol
• 英文别名: 1,2-Bis(1-methylethoxy)-2-(trifluormethyl)-2-propanol；HOC(CF3)(CH2OiPr)2
• CAS: 156572-66-6
• 化学式: C₁₀H₁₉F₃O₃
• 分子量: 244.254
• InChiKey: IGVYXSFFDJCTLU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.13
• 重原子数：
  16.0
• 可旋转键数：
  6.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  38.69
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  cobalt(II) bis(trimethylsilyl)amide 、 1,3-bis-(1-methylethoxy)-2-(trifluoromethyl)-2-propanol 以 正己烷 为溶剂， 生成 bis{bis 1,3-bis(1-methylethoxy)-2-(trifluoromethyl)-propanolato}cobalt(II)
  参考文献：
  名称：

  Herrmann, Wolfgang A.; Huber, Norbert W., Chemische Berichte, 1994, vol. 127, # 5, p. 821 - 824

  摘要：

  DOI：
• 作为产物：
  描述：

  isopropoxymethyl-magnesium chloride 、 三氟乙酸酐 以 四氢呋喃 为溶剂， 反应 38.0h， 以53%的产率得到1,3-bis-(1-methylethoxy)-2-(trifluoromethyl)-2-propanol
  参考文献：
  名称：

  Herrmann, Wolfgang A.; Huber, Norbert W., Chemische Berichte, 1994, vol. 127, # 5, p. 821 - 824

  摘要：

  DOI：

文献信息

• Volatile Metal Alkoxides according to the Concept of Donor Functionalization
  作者：Wolfgang A. Herrmann、Norbert W. Huber、Oliver Runte

  DOI：10.1002/anie.199521871

  日期：1995.11.3

  AbstractSince the fundamental works of D. C. Bradley and R. C. Mehrotra, metal alkoxides have attracted attention because of the diversity of their low‐ and high‐molecular‐weight structures; they are also generating increasing interest as precursor compounds for solving technical materials problems. The understanding of the hydrolytic nucleation behavior is a prerequisite for the optimization of materials from sol–gel processes. For metal alkoxides to be precursors in chemical vapor deposition (CVD) processes in the preparation of inorganic oxidic materials, they should be sufficiently volatile, and sublimation should occur without decomposition at as low a temperature as possible (< 150 °C). Only recently, using the “donor functionalization” concept, was a ligand type systematically developed that unifies the advantages of both steric demands and σ‐donor stabilization and so stabilizes low‐molecularweight metal alkoxides. Even large metal ions of low charge (for example Ba2+) can thus form volatile alkoxides. O‐ and N‐donor functions in bidentate and multidentate alkoxo ligands are particularly advantageous; hence, for example, the vanadium derivative [V(OCMe2CH2OMe)3] is one of the most volatile metal alkoxides known to date. The first alkoxides of the alkaline earth metals calcium, strontium, and barium, which sublime without decomposition, have the formula [M2OC(CH2OiPr)2tBu}4]. This article presents a critical inventory of the metal alkoxides with particular regard to the aspect of volatility. It also describes successes of the donor functionalization concept and shows—in prespective—how alkoxo ligands can be “tailor made” for metals according to their charge‐to‐radius ratio by further development of the concept.