(allyloxy)cycloheptane | 1256151-38-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (allyloxy)cycloheptane
• 英文别名: Prop-2-enoxycycloheptane
• CAS: 1256151-38-8
• 化学式: C₁₀H₁₈O
• 分子量: 154.252
• InChiKey: YFWVFHHFYVYWBQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (allyloxy)cycloheptane 在 lithium diisopropyl amide 作用下， 以 四氢呋喃 、 正戊烷 为溶剂， 以99%的产率得到(Z)-(prop-1-en-1-yloxy)cycloheptane
  参考文献：
  名称：

  Isomerization of Allyl Ethers Initiated by Lithium Diisopropylamide

  摘要：

  Lithium diisopropylamide (LDA) promotes virtually quantitative conversion of allylic ethers to (Z)-propenyl ethers. It was discovered that allylic ethers can be isomerized efficiently with very high stereoselectivity to (Z)-propenyl ethers by LDA in THF at room temperature. The reaction time for the conversion increases with more sterically hindered allylic ethers. Different amides were also compared with LDA for their ability to effect this isomerization.

  DOI：

  10.1021/ol102029u
• 作为产物：
  描述：

  环庚醇 、 3-溴丙烯 在 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 反应 0.17h， 以80%的产率得到(allyloxy)cycloheptane
  参考文献：
  名称：

  Isomerization of Allyl Ethers Initiated by Lithium Diisopropylamide

  摘要：

  Lithium diisopropylamide (LDA) promotes virtually quantitative conversion of allylic ethers to (Z)-propenyl ethers. It was discovered that allylic ethers can be isomerized efficiently with very high stereoselectivity to (Z)-propenyl ethers by LDA in THF at room temperature. The reaction time for the conversion increases with more sterically hindered allylic ethers. Different amides were also compared with LDA for their ability to effect this isomerization.

  DOI：

  10.1021/ol102029u

文献信息

• 2,3,4,9-Tetrahydro-1H-carbazoles
  申请人：Bayer Schering Pharma Aktiengesellschaft

  公开号：EP1975159A1

  公开（公告）日：2008-10-01

  The present invention relates to 2,3,4,9-tetrahydro-1 H-carbazoles of the general formula I, in which Q, X, W, R1, R2, R3, R4 and R5 have the meaning as defined in the description. The compounds according to the invention are effective FSH antagonists and can be used for example for fertility control in men or in women, or for the prevention and/or treatment of osteoporosis.

  本发明涉及通式I的2,3,4,9-四氢-1H-咔唑， 其中Q、X、W、R1、R2、R3、R4和R5的含义如描述中所定义。 根据本发明的化合物是有效的FSH拮抗剂，可用于男性或女性的生育控制，或用于骨质疏松症的预防和/或治疗。
• Arylmethylene substituted N-acyl-beta-amino alcohols
  申请人：Bayer Schering Pharma Aktiengesellschaft

  公开号：EP2018859A1

  公开（公告）日：2009-01-28

  The present invention relates to arylmethylene substituted N-Acyl-β-amino alcohols of the formula I in which Y is selected from the aryl or heteroaryl groups: and R1, R2, R3, R4, R5, Q, X and W have the meaning as defined in the description. The compounds according to the invention are effective FSH antagonists and can be used for example for fertility control in men or in women, or for the prevention and/or treatment of osteoporosis.

  本发明涉及式I的芳基亚甲基取代的N-酰基-β-氨基醇 其中 Y 从芳基或杂芳基中选择: 和 R1、R2、R3、R4、R5、Q、X和W的含义如描述中所定义。 根据本发明的化合物是有效的FSH拮抗剂，例如可用于男性或女性的生育控制，或用于骨质疏松症的预防和/或治疗。
• Cyanomethyl substituted N-Acyl Tryptamines
  申请人：Bayer Schering Pharma Aktiengesellschaft

  公开号：EP2020404A1

  公开（公告）日：2009-02-04

  The present invention relates to cyanomethyl substituted N-acyl tryptamines of the formula I in which R1, R2, R3, R4, R5, Q, X and W have the meaning as defined in the description. The compounds according to the invention are effective FSH antagonists and can be used for example for fertility control in men or in women, or for the prevention and/or treatment of osteoporosis.

  本发明涉及具有以下结构的氰甲基取代的N-酰基色胺化合物，其中R1、R2、R3、R4、R5、Q、X和W的含义如描述中所定义。根据本发明的化合物是有效的FSH拮抗剂，可用于男性或女性的生育控制，或用于骨质疏松症的预防和/或治疗。
• Sulphonyltryptophanols
  申请人：Bayer Schering Pharma Aktiengesellschaft

  公开号：EP1964834A1

  公开（公告）日：2008-09-03

  The present invention relates to sulfonyltryptophanols of the general formula I, in which Q, X, W, R1, R2, R3, R4, R5, R6, R7 and R8 have the meaning as defined in the description. The compounds according to the invention are effective FSH receptor antagonists and can be used for example for fertility control in men or in women, or for the prevention and/or treatment of osteoporosis.

  本发明涉及通式I的磺酰色氨酸醇类化合物，其中Q、X、W、R1、R2、R3、R4、R5、R6、R7和R8的含义如描述中所定义。根据本发明的化合物是有效的FSH受体拮抗剂，可用于男性或女性的生育控制，以及骨质疏松症的预防和/或治疗。
• 1,2-Diarylacetylene Derivatives of Acyltryptophanols
  申请人：Bayer Schering Pharma Aktiengesellschaft

  公开号：EP1932831A1

  公开（公告）日：2008-06-18

  The present invention relates to acyltryptophanols of the general formula I, in which Q, W, R1, R2, R3, R4, R5, R6, R7 and R8 have the meaning as defined in the description. The compounds according to the invention are effective FSH antagonists and can be used for example for fertility control in men or in women, or for the prevention and/or treatment of osteoporosis.

  本发明涉及通式I的酰基色氨酸醇，其中Q、W、R1、R2、R3、R4、R5、R6、R7和R8的含义如描述中所定义。根据本发明的化合物是有效的FSH拮抗剂，可用于例如男性或女性的生育控制，或用于骨质疏松症的预防和/或治疗。