(Z)-3-(3'-hydroxyphenyl)-1-phenylprop-2-en-1-ol | 188957-38-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: (Z)-3-(3'-hydroxyphenyl)-1-phenylprop-2-en-1-ol
• 英文别名: 3-[(Z)-3-hydroxy-3-phenylprop-1-enyl]phenol
• CAS: 188957-38-2
• 化学式: C₁₅H₁₄O₂
• 分子量: 226.275
• InChiKey: KEXCMAIUYPEHRF-KTKRTIGZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (Z)-3-(3'-hydroxyphenyl)-1-phenylprop-2-en-1-ol 在 1,1,3-三甲基-3-苯基二氢化茚-4,5-二甲酸 、 二异丁基氢化铝 作用下， 以 二氯甲烷 为溶剂， 反应 1.5h， 生成 6-hydroxy-2-phenyl-2H-chromene
  参考文献：
  名称：

  The synthesis of 8a-methoxy-2H,6H-chromen-6-ones and corresponding 2H-chromenes by a unique process utilising phenolic oxidation

  摘要：

  (Z)-1-Hydroxy-3-(3'-hydroxyphenyl)prop-2-enes undergo phenolic oxidation by phenyliodonium diacetate (PIDA) in methanol to give 8a-methoxy-2H,6H-dihydrochromen-6-ones. These are reduced by DIBAL-H to 2-substituted-Delta(3,4)-chromenes, the overall process being a unique heterocyclic synthesis in which the heteroatom is not initially attached to a benzene ring, but is introduced from a side chain. Parallel oxidations using cis-1-hydroxy-3-(3'-hydroxyphenyl)prop-2,3-oxiranes have also been achieved despite the presence of the sensitive oxirane ring. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4020(97)00008-2
• 作为产物：
  描述：

  3-碘苯酚 在 咪唑 、 二氯二茂钛 、 bis-triphenylphosphine-palladium(II) chloride 、 copper(l) iodide 、 Isobutylmagnesium chloride 、 二异丙胺 、 cesium fluoride 作用下， 以 甲醇 、 乙醚 、 二氯甲烷 为溶剂， 反应 51.0h， 生成 (Z)-3-(3'-hydroxyphenyl)-1-phenylprop-2-en-1-ol
  参考文献：
  名称：

  The synthesis of 8a-methoxy-2H,6H-chromen-6-ones and corresponding 2H-chromenes by a unique process utilising phenolic oxidation

  摘要：

  (Z)-1-Hydroxy-3-(3'-hydroxyphenyl)prop-2-enes undergo phenolic oxidation by phenyliodonium diacetate (PIDA) in methanol to give 8a-methoxy-2H,6H-dihydrochromen-6-ones. These are reduced by DIBAL-H to 2-substituted-Delta(3,4)-chromenes, the overall process being a unique heterocyclic synthesis in which the heteroatom is not initially attached to a benzene ring, but is introduced from a side chain. Parallel oxidations using cis-1-hydroxy-3-(3'-hydroxyphenyl)prop-2,3-oxiranes have also been achieved despite the presence of the sensitive oxirane ring. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4020(97)00008-2

文献信息

• The synthesis of 8a-methoxy-2H,6H-chromen-6-ones and corresponding 2H-chromenes by a unique process utilising phenolic oxidation
  作者：Andrew Pelter、Amjad Hussain、Gareth Smith、Robert S Ward

  DOI：10.1016/s0040-4020(97)00008-2

  日期：1997.3

  (Z)-1-Hydroxy-3-(3'-hydroxyphenyl)prop-2-enes undergo phenolic oxidation by phenyliodonium diacetate (PIDA) in methanol to give 8a-methoxy-2H,6H-dihydrochromen-6-ones. These are reduced by DIBAL-H to 2-substituted-Delta(3,4)-chromenes, the overall process being a unique heterocyclic synthesis in which the heteroatom is not initially attached to a benzene ring, but is introduced from a side chain. Parallel oxidations using cis-1-hydroxy-3-(3'-hydroxyphenyl)prop-2,3-oxiranes have also been achieved despite the presence of the sensitive oxirane ring. (C) 1997 Elsevier Science Ltd.