α-1,5-anhydro-1-C-methyl-2,3,4,6-tetra-O-methyl-D-glucitol | 115514-25-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: α-1,5-anhydro-1-C-methyl-2,3,4,6-tetra-O-methyl-D-glucitol
• 英文别名: (2R,3R,4R,5S,6R)-3,4,5-trimethoxy-2-(methoxymethyl)-6-methyloxane
• CAS: 115514-25-5；115588-66-4
• 化学式: C₁₁H₂₂O₅
• 分子量: 234.293
• InChiKey: MKCFMWMMGKZYHT-KAMPLNKDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  46.2
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2,3,4,6-tetra-O-methyl-α-D-glucopyranosyl bromide 生成 α-1,5-anhydro-1-C-methyl-2,3,4,6-tetra-O-methyl-D-glucitol
  参考文献：
  名称：

  BIHOVSKY, RON;SELICK, CARYN;GIUSTI, IRENA, J. ORG. CHEM., 53,(1988) N 7, C. 4026-4031

  摘要：

  DOI：

文献信息

• PROCESS FOR PRODUCTION OF GLUCOPYRANOSYLOXYPYRAZOLE DERIVATIVE
  申请人：Kasai Kiyoshi

  公开号：US20090062518A1

  公开（公告）日：2009-03-05

  The present invention relates to a method for preparing the glucopyranosyloxypyrazole derivatives which are useful as agents for the prevention or treatment of a disease associated with hyperglycemia such as diabetes, diabetic complications, obesity or the like. A glucopyranosyloxypyrazole derivative can be easily and efficiently prepared by allowing a benzylpyrazole derivative represented by the general formula: wherein R 1 , R 2 , R 3 , R 4 and R 5 may be the same or different, for example each of them is a hydrogen atom, a halogen atom or an alkyl, alkoxy, arylmethyloxy group or the like, R 6 is an alkyl group, for example R 7 is a hydrogen atom or an alkyl, alkoxy, arylmethyloxy group or the like, to react with a compound represented by the general formula: wherein as an example, PG 1 is a pivaloyl group or the like, as an example, X 1 is a bromine atom or the like, therefore the present invention is extremely useful as a method for preparing pharmaceutical compounds.

  本发明涉及一种制备葡萄糖吡唑氧基吡唑衍生物的方法，该衍生物可用作预防或治疗与高血糖相关的疾病，如糖尿病、糖尿病并发症、肥胖症等的药物。通过让一个苄基吡唑衍生物与一个化合物反应，可以轻松高效地制备葡萄糖吡唑氧基吡唑衍生物。其中，该苄基吡唑衍生物由下列通式表示：其中R1、R2、R3、R4和R5可以相同也可以不同，例如每个都是氢原子、卤素原子或烷基、烷氧基、芳基甲氧基等，R6是烷基，例如R7是氢原子或烷基、烷氧基、芳基甲氧基等。化合物由下列通式表示：其中，PG1是一个Pivaloyl基团或类似物，例如，X1是溴原子或类似物。因此，本发明作为一种制备药物化合物的方法非常有用。
• Synthesis of C-glucosides by reactions of glucosyl halides with organocuprates
  作者：Ron Bihovsky、Caryn Selick、Irena Giusti

  DOI：10.1021/jo00252a027

  日期：1988.8
• BIHOVSKY, RON;SELICK, CARYN;GIUSTI, IRENA, J. ORG. CHEM., 53,(1988) N 7, C. 4026-4031
  作者：BIHOVSKY, RON、SELICK, CARYN、GIUSTI, IRENA

  DOI：——

  日期：——
• US8022192B2
  申请人：——

  公开号：US8022192B2

  公开（公告）日：2011-09-20