Methyl 5-[2-[5-(4-methylphenyl)sulfanyl-2-phenyl-1,3-oxazole-4-carbonyl]hydrazinyl]-2-phenyl-1,3-oxazole-4-carboxylate | 1225161-87-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: Methyl 5-[2-[5-(4-methylphenyl)sulfanyl-2-phenyl-1,3-oxazole-4-carbonyl]hydrazinyl]-2-phenyl-1,3-oxazole-4-carboxylate
• CAS: 1225161-87-4
• 化学式: C₂₈H₂₂N₄O₅S
• 分子量: 526.572
• InChiKey: WTNULLSGXSDWNK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.4
• 重原子数：
  38
• 可旋转键数：
  9
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  145
• 氢给体数：
  2
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  Methyl 5-[2-[5-(4-methylphenyl)sulfanyl-2-phenyl-1,3-oxazole-4-carbonyl]hydrazinyl]-2-phenyl-1,3-oxazole-4-carboxylate 在 溶剂黄146 作用下， 反应 8.0h， 以76%的产率得到Methyl (5-{5-[(4-methylphenyl)sulfanyl]-2-phenyl-1,3-oxazol-4-yl}-1,3,4-oxadiazol-2-yl)[(phenylcarbonyl)amino]acetate
  参考文献：
  名称：

  2-aryl-5-arylsulfanyl-1,3-oxazole-4-carboxylic acids and their derivatives

  摘要：

  A convenient preparative procedure has been developed for the synthesis of previously unknown 2-aryl- 5-arylsulfanyl-1,3-oxazole-4-carboxylic acids and their functional derivatives from accessible multicenter substrates of the general formula Cl(2)C=C(NHCOR)C(O)OMe. The products turned out to be suitable for various subsequent transformations. Some oxazole-4-carboxylic acid hydrazide derivatives containing a substituted oxazol-5-yl fragment at the N(2) atom in the hydrazine moiety underwent recyclization on heating in acetic acid; as a result, one oxazole ring was converted into 1,3,4-oxadiazole.

  DOI：

  10.1134/s1070363210070212
• 作为产物：
  描述：

  methyl ester of 3,3-dichloro-2-benzoylaminoacrylic acid 在 氯化亚砜 、 水 、 N,N-二甲基苯胺 、 sodium hydroxide 作用下， 以 乙醇 、 乙腈 、 苯 为溶剂， 反应 1.0h， 生成 Methyl 5-[2-[5-(4-methylphenyl)sulfanyl-2-phenyl-1,3-oxazole-4-carbonyl]hydrazinyl]-2-phenyl-1,3-oxazole-4-carboxylate
  参考文献：
  名称：

  2-aryl-5-arylsulfanyl-1,3-oxazole-4-carboxylic acids and their derivatives

  摘要：

  A convenient preparative procedure has been developed for the synthesis of previously unknown 2-aryl- 5-arylsulfanyl-1,3-oxazole-4-carboxylic acids and their functional derivatives from accessible multicenter substrates of the general formula Cl(2)C=C(NHCOR)C(O)OMe. The products turned out to be suitable for various subsequent transformations. Some oxazole-4-carboxylic acid hydrazide derivatives containing a substituted oxazol-5-yl fragment at the N(2) atom in the hydrazine moiety underwent recyclization on heating in acetic acid; as a result, one oxazole ring was converted into 1,3,4-oxadiazole.

  DOI：

  10.1134/s1070363210070212

文献信息

• 2-aryl-5-arylsulfanyl-1,3-oxazole-4-carboxylic acids and their derivatives
  作者：S. G. Pil’o、V. M. Prokopenko、V. S. Brovarets、B. S. Drach

  DOI：10.1134/s1070363210070212

  日期：2010.7

  A convenient preparative procedure has been developed for the synthesis of previously unknown 2-aryl- 5-arylsulfanyl-1,3-oxazole-4-carboxylic acids and their functional derivatives from accessible multicenter substrates of the general formula Cl(2)C=C(NHCOR)C(O)OMe. The products turned out to be suitable for various subsequent transformations. Some oxazole-4-carboxylic acid hydrazide derivatives containing a substituted oxazol-5-yl fragment at the N(2) atom in the hydrazine moiety underwent recyclization on heating in acetic acid; as a result, one oxazole ring was converted into 1,3,4-oxadiazole.