4-甲氧基-2,6-二甲基-嘧啶 | 14001-62-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 4-甲氧基-2,6-二甲基-嘧啶
• 中文别名: 4-甲氧基-2,6-二甲基嘧啶
• 英文名称: 4-Methoxy-2,6-dimethyl-pyrimidin
• 英文别名: 6-Methoxy-2,4-dimethyl-pyrimidin；4-Methoxy-2,6-dimethylpyrimidine
• CAS: 14001-62-8
• 化学式: C₇H₁₀N₂O
• mdl: MFCD18377698
• 分子量: 138.169
• InChiKey: NBLOKQVJTMLMRG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.428
• 拓扑面积：
  35
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H315,H319,H335

反应信息

• 作为反应物：
  描述：

  4-甲氧基-2,6-二甲基-嘧啶 在 镍 氢气 、 zinc(II) chloride 作用下， 以 甲醇 为溶剂， 25.0~160.0 ℃ 、101.33 kPa 条件下， 反应 6.0h， 生成 6-methoxy-4-methyl-2-phenethylpyrimidine
  参考文献：
  名称：

  Sakamoto, Takao; Yoshizawa, Hiroshi; Yamanaka, Hiroshi, Chemical and pharmaceutical bulletin, 1984, vol. 32, p. 2005 - 2010

  摘要：

  DOI：
• 作为产物：
  描述：

  2-氨基-4-氯-6-甲基嘧啶 在 sodium methylate 作用下， 生成 4-甲氧基-2,6-二甲基-嘧啶
  参考文献：
  名称：

  Andrisano; Modena, Gazzetta Chimica Italiana, 1951, vol. 81, p. 405,412

  摘要：

  DOI：

文献信息

• [EN] PROTEOSTASIS REGULATORS FOR TREATING CYSTIC FIBROSIS AND OTHER PROTEIN MISFOLDING DISEASES<br/>[FR] RÉGULATEURS DE PROTÉOSTASIE POUR LE TRAITEMENT DE LA MUCOVISCIDOSE ET AUTRES MALADIES DE MAUVAIS REPLIEMENT DES PROTÉINES
  申请人：PROTEOSTASIS THERAPEUTICS INC

  公开号：WO2012154880A1

  公开（公告）日：2012-11-15

  The present invention is directed to compounds of Formulae (Ia-Ib), (Ila-IId), (Illa- Illb), (IV), (V), (VI), (Vlla-VIIc), (VIII), (IXa-IXb), (Xa-Xb), (XIa-XIb) and (Xlla-XIIb), pharmaceutical compositions thereof and methods of use thereof in the treatment of conditions associated with a dysfunction in proteostasis.

  本发明涉及式(Ia-Ib)、(IIa-IId)、(IIIa-IIIb)、(IV)、(V)、(VI)、(VIla-VIIc)、(VIII)、(IXa-IXb)、(Xa-Xb)、(XIa-XIb)和(XIIa-XIIb)的化合物，以及这些化合物的药物组合物和在治疗与蛋白质稳态失调相关的疾病中的使用方法。
• [EN] SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS SIRTUIN MODULATORS<br/>[FR] AZA-HÉTÉROCYCLES BICYCLIQUES SUBSTITUÉS ET ANALOGUES EN TANT QUE MODULATEURS DES SIRTUINES
  申请人：SIRTRIS PHARMACEUTICALS INC

  公开号：WO2013059589A1

  公开（公告）日：2013-04-25

  Provided herein are novel substituted bicyclic aza-heterocycle sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided, are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

  本文提供了一种新型的取代双环氮杂杂环丝氨酸调控化合物及其使用方法。这些丝氨酸调控化合物可用于延长细胞寿命，治疗和/或预防各种疾病和紊乱，包括与老化或压力、糖尿病、肥胖、神经退行性疾病、心血管疾病、血液凝块紊乱、炎症、癌症、潮红以及需要增加线粒体活性的疾病或紊乱。此外，还提供了包含丝氨酸调控化合物与另一种治疗剂组合的组合物。
• Studies on Nitrofuran Derivatives. IV. Synthesis of 2- or 4-[2-(5-Nitro-2-furyl) vinyl] pyrimidine Derivatives
  作者：Akio Fujita、Tadatsugu Yamamoto、Shinsaku Minami、Hideji Takamatsu

  DOI：10.1248/cpb.13.1183

  日期：——

  To test the antibacterial activity, 2- or 4-[2-(5-nitro-2-furyl) vinyl] pyrimidines were synthesized by the condensation of 5-nitro-2-furaldehyde (Va) with the active methyl group of pyrimidines. It has been found that Va predominantly condensed with the 4-methyl group of 2, 4-dimethylpyrimidine and in the reaction of Va with 2, 4-dimethylpyrimidine containing a functional group in the 6-position, the active hydrogen reactivity between the 2-methyl group and 4-methyl group is affected by the presence of group in the 6-position : in 2, 4-dimethylpyrimidines substituted by the hydroxy, amino and alkoxy group in the 6-position, the 2-methyl group was founded to be more active, while in the ones substituted by the acetamido, dimethylamino and chloro group, the 4-methyl group was more reactive.

  为了测试抗菌活性，通过 5-硝基-2-呋喃甲醛（Va）与嘧啶的活性甲基缩合，合成了 2-或 4-[2-（5-硝基-2-呋喃基）乙烯基]嘧啶。研究发现，Va 主要与 2，4-二甲基嘧啶的 4-甲基缩合，在 Va 与 6 位含有官能团的 2，4-二甲基嘧啶反应时，2-甲基和 4-甲基之间的活性氢反应性受 6 位官能团的影响：在 6 位被羟基、氨基和烷氧基取代的 2，4-二甲基嘧啶中，2-甲基基团的活性更高，而在被乙酰氨基、二甲基氨基和氯基团取代的 2，4-二甲基嘧啶中，4-甲基基团的活性更高。
• 4-Cyclopropyl-1,2,3,-Thiadiazole Compound, Agrohorticultural Plant Disease Controlling Agent And Method Of Using The Same
  申请人：Umetani Kunihisa

  公开号：US20080200457A1

  公开（公告）日：2008-08-21

  The present invention relates to 1,2,3 -thiadiazole compounds represented by formula (I): wherein R 1 , R 2 , R 3 , R 4 and R 5 each represents H, halogen, CN, alkyl, alkoxyalkyl, aryl, arylalkyl, alkylcarbonyl or the like; R 6 represents —C═(W 1 )YR 7 in which R 7 reresents H, alkyl, alkenyl, phenylcarbonyl, heterocyclic ring-carbonyl, arylsulfonyl or the like; Y represents O, S, —N(R 11 ), —N(R 11 )O— in which R 11 represents H, alkyl, cycloalkyl, substituted phenyl, or the like; W 1 represents O or S; and symbols in the formula are defined in detail in the specification or salts thereof, and to a plant disease control agent for agricultural and horticultural use which contains the compound as an active ingredient.

  本发明涉及由式（I）表示的1,2,3-噻二唑化合物：其中R1、R2、R3、R4和R5每个代表H、卤素、CN、烷基、烷氧基烷基、芳基、芳基烷基、烷基羰基或类似物；R6表示-C═（W1）YR7，其中R7代表H、烷基、烯基、苯基羰基、杂环环-羰基、芳基磺酰基或类似物；Y表示O、S、-N（R11）、-N（R11）O-，其中R11代表H、烷基、环烷基、取代苯基或类似物；W1表示O或S；以及该化合物的盐，以及包含该化合物作为活性成分的用于农业和园艺的植物病害控制剂。
• Pyrrolo-Pyridine, Pyrrolo-Pyrimidine and Related Heterocyclic Compounds
  申请人：Yuan Jun

  公开号：US20080267887A1

  公开（公告）日：2008-10-30

  Pyrrolo-pyridine, pyrrolo-pyrimidine and related heterocyclic compounds analogues of the formula: wherein R, R 2 , R 5 , E, Z 1 , Z 3 , Z 4 , and Ar are defined herein. Such compounds are ligands of C5a receptors. Preferred pyrrolo-pyridine, pyrrolo-pyrimidine and related heterocyclic compounds of the invention bind to C5a receptors with high affinity and exhibit neutral antagonist or inverse agonist activity at C5a receptors. The present invention also relates to pharmaceutical compositions comprising such compounds, and to the use of such compounds in treating a variety of inflammatory, cardiovascular, and immune system disorders. In addition, the present invention provides labeled pyrrolo-pyridine, pyrrolo-pyrimidine and related heterocyclic compounds, which are useful as probes for the localization of C5a receptors.

  吡咯吡啶、吡咯嘧啶和相关杂环化合物的类似物的公式如下： 其中R，R2，R5，E，Z1，Z3，Z4和Ar在此定义。这些化合物是C5a受体的配体。本发明所述的优选吡咯吡啶、吡咯嘧啶和相关杂环化合物以高亲和力结合到C5a受体，并在C5a受体上表现出中性拮抗剂或反向激动剂活性。本发明还涉及包含这些化合物的药物组合物，并且涉及使用这些化合物治疗各种炎症、心血管和免疫系统疾病。此外，本发明提供了标记的吡咯吡啶、吡咯嘧啶和相关杂环化合物，这些化合物可用作C5a受体的定位探针。