2-[2-[2-[2-[11-[11-[2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]ethoxy]undecyldisulfanyl]undecoxy]ethoxy]ethoxy]ethoxy]ethanol | 866558-26-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-[2-[2-[2-[11-[11-[2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]ethoxy]undecyldisulfanyl]undecoxy]ethoxy]ethoxy]ethoxy]ethanol
• CAS: 866558-26-1
• 化学式: C₃₈H₇₈O₁₀S₂
• 分子量: 759.163
• InChiKey: NGYQAKNMVZIIAB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.6
• 重原子数：
  50
• 可旋转键数：
  47
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  165
• 氢给体数：
  2
• 氢受体数：
  12

反应信息

• 作为反应物：
  描述：

  2-[2-[2-[2-[11-[11-[2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]ethoxy]undecyldisulfanyl]undecoxy]ethoxy]ethoxy]ethoxy]ethanol 在 pyridine-SO3 complex 、 水 、 sodium hydroxide 作用下， 以 N,N-二甲基甲酰胺 、 甲醇 为溶剂， 反应 6.0h， 以74%的产率得到
  参考文献：
  名称：

  Gold nanoparticles capped with sulfate-ended ligands as anti-HIV agents

  摘要：

  Gold nanoparticles coated with multiple copies of an amphiphilic sulfate-ended ligand are able to bind the HIV envelope glycoprotein gp120 as measured by surface plasmon resonance (SPR) and inhibit in vitro the HIV infection of T-cells at nanomolar concentrations. A 50% density of sulfated ligands on similar to 2 nm nanoparticles (the other ligands being inert glucose derivatives) is enough to achieve high anti-HIV activities. This result opens up the possibility of tailoring both sulfated ligands and other anti-HIV molecules on the same gold cluster, thus contributing to the development of non-cocktail based multifunctional anti-HIV systems. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.03.079
• 作为产物：
  描述：

  11-溴-1-十一烯 在 盐酸 、 氨甲基膦酸 、 potassium carbonate 、 copper(II) sulfate 、 sodium hydroxide 作用下， 以 1,4-二氧六环 、 甲醇 为溶剂， 生成 2-[2-[2-[2-[11-[11-[2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]ethoxy]undecyldisulfanyl]undecoxy]ethoxy]ethoxy]ethoxy]ethanol
  参考文献：
  名称：

  On-Demand Electrochemical Activation of the Click Reaction on Self-Assembled Monolayers on Gold Presenting Masked Acetylene Groups

  摘要：

  We report on a new surface modification method for grafting a "dynamic" property for on-demand activation of the click reaction. Our approach utilizes the acetylene group masked with dicobalt hexacarbonyl, Co-2-(CO)(6), which is not reactive toward the click reaction. Electrochemical treatment reveals the acetylene group on the selected region, which is then used as a chemical handle for surface functionalization via the click reaction with an azide-containing molecule. Electrochemical and chemical conversions on the surface were verified by cyclic voltammetry, X-ray photoelectron spectroscopy, and fluorescence spectroscopy. We have demonstrated immobilization of an azide-modified RGD peptide and promotion of cell adhesion/migration to the region of electrochemical induction.

  DOI：

  10.1021/ja2083587

文献信息

• SUGAR CHAIN CONTAINING 4-POSITION HALOGENATED GALACTOSE AND APPLICATION THEREOF
  申请人：Nishimura Shin-Ichiro

  公开号：US20090018327A1

  公开（公告）日：2009-01-15

  The present invention is directed to, for example, an oligosaccharide having at an end thereof a 4-position halogenated galactose residue represented by formula (I): (wherein X represents a halogen atom, and R represents a monosaccharide, an oligosaccharide, or a carrier), a transferase inhibitor containing the oligosaccharide, and a method for inhibiting sugar chain elongation reaction in the presence of glycosyltransferase, the method including employing the inhibitor. The invention also provides a method for producing a 4-position halogenated galactose sugar nucleotide represented by formula (II): (wherein each of R 1 to R 3 represents a hydroxyl group, an acetyl group, a halogen atom, or a hydrogen atom; X represents a halogen atom; and M represents a hydrogen ion or a metal ion), wherein the method employs bacterium-derived galactokinase and bacterium-derived hexose-1-phosphate uridylyltransferase. The invention is also directed to a sugar chain containing 4-position halogenated galactose envisaged to be employed as drugs and other materials, and to applications of the compound.

  本发明涉及一种寡糖，其末端具有由公式(I)表示的4位卤代半乳糖残基：（其中X代表卤素原子，R代表单糖，寡糖或载体），含有该寡糖的转移酶抑制剂，以及在存在糖基转移酶时抑制糖链延长反应的方法，该方法包括使用该抑制剂。该发明还提供了一种生产由公式(II)表示的4位卤代半乳糖核苷酸的方法：（其中R1至R3中的每一个代表羟基、乙酰基、卤素原子或氢原子；X代表卤素原子；M代表氢离子或金属离子），该方法利用细菌来源的半乳糖激酶和细菌来源的己糖-1-磷酸尿苷转移酶。本发明还涉及一种含有4位卤代半乳糖的糖链，可用作药物和其他材料，并涉及该化合物的应用。
• Selective Immobilization of Peptides Exclusively via N-Terminus Cysteines by Water-Driven Reactions on Surfaces
  作者：Preeti Sejwal、Sri Kamesh Narasimhan、Deepali Prashar、Debjyoti Bandyopadhyay、Yan-Yeung Luk

  DOI：10.1021/jo901085u

  日期：2009.9.4

  Immobilizing peptides or proteins on bioinert surfaces enables the elucidation of ligand-receptor interaction in complex biological systems. Here, we report a highly chemoselective surface reaction that immobilizes peptides exclusively via N-terminus cysteine residue in a peptide. At pH 5.5, only N-terminus cysteines of peptides couple covalently with phenoxy amino squarate moieties presented oil self-assembled monolayers (SAMs) of alkailethiols oil gold Films. The selectivity of this surface reaction can tolerate the presence of internal cysteines in close proximity to basic residues such as histidines. We demonstrated this selective surface reaction by mammalian cell adhesion and by SAMDI mass spectroscopy of the SAMs.
• Mass analysis method using fine metal particles
  申请人：Nagahori Noriko

  公开号：US20090206245A1

  公开（公告）日：2009-08-20

  It is an object of the present invention to provide a novel mass spectrometry method which overcomes the conventional problems mentioned above, which can analyze at a high sensitivity and high accuracy a chemical reaction on a surface of a self-organized membrane bound to a metal, and which can be applied to analysis of structures of a sugar chain in future. According to the present invention, a method for performing mass spectrometry of sulfur atom-containing derivatives of an organic residue, characterized in that the method includes ionizing a metal-organic residue complex into the derivatives, wherein the complex has the organic residue bound through a sulfur atom to the metal is provided, thereby solving the above problems.
• US8148112B2
  申请人：——

  公开号：US8148112B2

  公开（公告）日：2012-04-03
• [EN] CORE SHELL CONJUGATION OF SILICA NANOTUBE AND POLYTHIOPHENE FOR QCM APPLICATION AND METHOD FOR MAKING THE SAME<br/>[FR] CONJUGAISON COEUR-ÉCORCE D'UN NANOTUBE DE SILICE ET DE POLYTHIOPHÈNE UTILE DANS UNE MICROBALANCE À CRISTAL DE QUARTZ (QCM), ET PROCÉDÉ DE FABRICATION CORRESPONDANT
  申请人：BAR ILAN RES AND DEV COMPANY LTD

  公开号：WO2013042012A1

  公开（公告）日：2013-03-28

  A gold coated quartz crystal microbalance (QCM) electrode modified by a nanocomposite. The nanocomposite is based on silica nanotube covalently conjugated to polythiophene acetic acid functionalized by thiol groups in core shell morphology. Method of making the electrode and the nanocomposite are also provided.