α-D-Glcp-(1<->1)-β-D-Galp | 96480-24-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: α-D-Glcp-(1<->1)-β-D-Galp
• 英文别名: β-D-galactopyranosyl α-D-glucopyranoside；β-D-Galactopyranosyl-α-D-glucopyranosid；Glc(a1-1b)Gal；(2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxane-3,4,5-triol
• CAS: 96480-24-9
• 化学式: C₁₂H₂₂O₁₁
• 分子量: 342.3
• InChiKey: HDTRYLNUVZCQOY-MEYGDINOSA-N

物化性质

• 沸点：
  675.4±55.0 °C(Predicted)
• 密度：
  1.76±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -4.2
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  190
• 氢给体数：
  8
• 氢受体数：
  11

反应信息

• 作为产物：
  描述：

  2,3,4,6-四-O-乙酰基-Β-D-葡萄糖 在 甲醇 、 硝基甲烷 、 sodium methylate 、 氰化汞 作用下， 生成 α-D-Glcp-(1<->1)-β-D-Galp
  参考文献：
  名称：

  Helferich; Weis, Chemische Berichte, 1956, vol. 89, p. 314,319

  摘要：

  DOI：

文献信息

• Selectivity and efficiency of utilization of galactosyl-oligosaccharides by bifidobacteria.
  作者：YOSHIHIRO MINAMI、KOUHEI YAZAWA、KUMIKO NAKAMURA、ZENZO TAMURA

  DOI：10.1248/cpb.33.710

  日期：——

  Neogalactobiose (α-D-galactopyranosyl β-D-galactopyranoside), β-D-galactopyranosyl β-D-glucopyranoside, β-D-galactopyranosyl α-D-glucopyranoside, α-D-galactopyranosyl β-D-glucopyranoside (GII), and α-D-galactopyranosyl β-D-fructofuranosyl-(2→6)-β-D-fructofuranoside (Gf) were synthesized as sugar sources which might selectively and efficiently enhance the growth of bifidobacteria in the human intestines. Gf was synthesized by using levansucrase and the others by means of the Koenigs-Knorr reaction. The structures of these sugars were confirmed by enzymic hydrolysis. All of these sugars were utilized by almost all strains of Bifidobacterium tested. Among them, GII, Gf and stachyose were not utilized by Lactobacillus acidophilus or Streptococcus faecalis, and were utilized by only a few strains of Enterobacteriaceae (comparable to lactosucrose). Furthermore, as regards both the growth activity of bifidobacterial cells and the generation time of the cells, the three sugars were virtually as effective as lactose or lactosucrose.

  合成了新半乳糖双糖（α-D-半乳糖吡喃苷 β-D-半乳糖吡喃苷）、β-D-半乳糖吡喃苷 β-D-葡萄糖吡喃苷、β-D-半乳糖吡喃苷 α-D-葡萄糖吡喃苷、α-D-半乳糖吡喃苷 β-D-葡萄糖吡喃苷（GII）和α-D-半乳糖吡喃苷 β-D-果糖呋喃苷（2→6）-β-D-果糖呋喃苷（Gf），作为可能选择性和高效增强人类肠道双歧杆菌生长的糖源。Gf 是通过使用左旋糖酶合成的，其他糖则通过科尼希斯-克诺尔反应合成。通过酶水解确认了这些糖的结构。所有测试的双歧杆菌菌株几乎均有效利用了这些糖。其中，GII、Gf 和美洲蓟糖不被嗜酸乳杆菌或粪链球菌利用，仅被少数肠杆菌科的菌株利用（相当于乳糖蔗糖）。此外，在双歧杆菌细胞的生长活性和细胞代生时间方面，这三种糖的效果实际上与乳糖或乳糖蔗糖相当有效。
• NOVEL SULFATED OLIGOSACCHARIDE DERIVATIVES
  申请人：Ferro Vito

  公开号：US20110245196A1

  公开（公告）日：2011-10-06

  The invention relates to novel compounds that have utility as inhibitors of heparan sulfate-binding proteins; compositions comprising the compounds, and use of the compounds and compositions thereof for the antiangiogenic, antimetastatic, anti-inflammatory, antimicrobial, anticoagulant and/or antithrombotic treatment of a mammalian subject.

  本发明涉及新型化合物，其具有作为肝素硫酸结合蛋白抑制剂的效用；包含该化合物的组合物以及使用该化合物和组合物进行哺乳动物受体的抗血管生成、抗转移、抗炎、抗微生物、抗凝血和/或抗血栓治疗的用途。
• Dyeing composition comprising a cationic tertiary para-phenylenediamine and a monosaccharide or disaccharide, processes and uses
  申请人：L'OREAL

  公开号：US20040221400A1

  公开（公告）日：2004-11-11

  The present application relates to a composition for the dyeing of keratin fibres, particularly human keratin fibres such as hair, comprising, in an appropriate dyeing medium, at least one cationic tertiary paraphenylenediamine containing a pyrrolidine ring, and at least one particular carbohydrate selected from monosaccharides, disaccharides and mixtures thereof. The invention further relates to the dyeing process in which this composition is used.

  本申请涉及一种用于染色角蛋白纤维的组合物，特别是用于染发等人类角蛋白纤维。该组合物包含至少一种含有吡咯烷环的阳离子三苯二胺和至少一种特定的单糖、双糖或其混合物，在适当的染料介质中。本发明还涉及使用该组合物的染色过程。
• Verfahren zur Herstellung von epimerenfreien Zuckeralkoholen aus der Gruppe von Xylitol, Sorbitol (D-Glucitol), 4-O-beta-D-Galactopyranosyl-D-glucitol und 4-O-alpha-D-Glucopyranosyl-D-sorbitol
  申请人：BAYER AG

  公开号：EP0423525A1

  公开（公告）日：1991-04-24

  Die als Titelverbindungen genannten Zuckeralkohole kön­nen in epimerenfreier Form aus den korrespondierenden Zuckern durch katalytische Hydrierung in wäßriger Lösung mit Wasserstoff hergestellt werden, wobei man die Hy­drierung kontinuierlich bei 100-500 bar H₂ und 60-125°C an im Festbett angeordneten trägerfreien Formkörpern aus verpreßten Pulvern der Elemente der Eisengruppe des Periodensystems durchführt. Die Formkörper haben eine Druckfestigkeit von mehr als 50 N und eine inner Ober­fläche von 10-90 m² /g.

  通过在水溶液中用氢气进行催化氢化反应，可以从相应的糖类制得无表聚物形式的糖醇，其中氢化反应是在 100-500 巴 H₂和 60-125°C 的温度下在无载体的模制体上连续进行的，模制体是由在固定床中排列的元素周期表中铁族元素的压制粉末制成的。模制体的抗压强度大于 50 N，内表面积为 10-90 m² /g。
• Trehalose phosphorylase, its preparation and uses
  申请人：KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO

  公开号：EP0841397A2

  公开（公告）日：1998-05-13

  A thermostable trehalose phosphorylase which is obtainable from microorganisms of the genus Thermoanaerobium and which hydrolyzes trehalose in the presence of an inorganic phosphoric acid to form D-glucose and β-D-glucose-1-phosphoric acid. The trehalose phosphorylase can be also prepared by recombinant DNA technology. When the enzyme is allowed to contact with β-D-glucose-1-phosphoric acid as a saccharide donor in the presence of other saccharides, glucosyl-transferred saccharides including glucosyl-D-galactoside, which are conventionally known but scarcely obtainable, can be produced on an industrial-scale and in a relatively-low cost.

  一种可从热花生菌属微生物中获得的热稳定性脱卤糖磷酸化酶，它能在无机磷酸存在下水解脱卤糖，生成 D-葡萄糖和 β-D-葡萄糖-1-磷酸。也可以通过 DNA 重组技术制备妥尔糖磷酸化酶。在有其他糖类存在的情况下，让酶与β-D-葡萄糖-1-磷酸作为糖类供体接触，就能以相对较低的成本在工业规模上生产出葡萄糖基转移的糖类，包括葡萄糖基-D-半乳糖苷。