二苄基(氯)膦 | 17850-02-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 二苄基(氯)膦
• 英文名称: Di-benzyl-chlor-phosphin
• 英文别名: Dibenzylphosphinous chloride；dibenzyl(chloro)phosphane
• CAS: 17850-02-1
• 化学式: C₁₄H₁₄ClP
• 分子量: 248.692
• InChiKey: GEQHSJWVCCJNMP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  二苄基(氯)膦 在 双氧水 作用下， 生成 dibenzylphosphinic acid
  参考文献：
  名称：

  Petrov,K.A. et al., Journal of general chemistry of the USSR, 1961, vol. 31, p. 2823 - 2825

  摘要：

  DOI：
• 作为产物：
  描述：

  氯化苄 在 磷化氢 作用下， 生成 二苄基(氯)膦
  参考文献：
  名称：

  Petrov,K.A. et al., Journal of general chemistry of the USSR, 1961, vol. 31, p. 2823 - 2825

  摘要：

  DOI：

文献信息

• Inhibitors of p38
  申请人：Bemis W. Guy

  公开号：US20050009844A1

  公开（公告）日：2005-01-13

  The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.

  本发明涉及p38的抑制剂，p38是一种哺乳动物蛋白激酶，与细胞增殖、细胞死亡和对细胞外刺激的反应有关。本发明还涉及制备这些抑制剂的方法。本发明还提供包含本发明抑制剂的制药组合物以及利用这些组合物治疗和预防各种疾病的方法。
• INHIBITORS OF p38
  申请人：Bemis Guy W.

  公开号：US20110281878A1

  公开（公告）日：2011-11-17

  The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.

  本发明涉及p38的抑制剂，p38是一种哺乳动物蛋白激酶，参与细胞增殖、细胞死亡和对细胞外刺激的反应。本发明还涉及制备这些抑制剂的方法。本发明还提供了包含本发明抑制剂的药物组合物，并提供了利用这些组合物治疗和预防各种疾病的方法。
• Process for transhalogenating a halophosphorus compound with fluoride
  申请人：ETHYL CORPORATION

  公开号：EP0312790A2

  公开（公告）日：1989-04-26

  Phosphorus compounds having at least one chlorine, bromine or iodine bonded directly to phosphorus are trans­halogenated with fluorine by reaction with a fluoride salt, e.g., KF or ammonium fluoride, in the presence of a hydrogen halide salt of a pyridine-type nitrogen base, e.g., pyridine hydrochloride.

  在吡啶型氮基（如盐酸吡啶）的卤化氢盐存在下，与氟化盐（如 KF 或氟化铵）反应，使至少有一个氯、溴或碘直接与磷键合的磷化合物与氟反卤化。
• Transhalogenation of halophosphorus compounds
  申请人：ETHYL CORPORATION

  公开号：EP0353598A2

  公开（公告）日：1990-02-07

  Phosphorus compounds having at least one chlorine, bromine or iodine bonded directly to phosphorus are trans­halogenated with fluorine by reaction with a hydrogen fluoride salt of a pyridine-type nitrogen base, e.g., pyridine hydrofluoride in an inert solvent.

  通过在惰性溶剂中与吡啶型氮基（如氟化氢吡啶）的氟化氢盐反应，使至少有一个氯、溴或碘直接与磷键合的磷化合物与氟发生反卤化反应。
• Process for transhalogenating a halophosphorus compound with hydrogen fluoride
  申请人：ALBEMARLE CORPORATION

  公开号：EP0357048A2

  公开（公告）日：1990-03-07

  Phosphorus compounds having at least one chlorine, bromine or iodine bonded directly to phosphorus are trans­halogenated with fluorine by reaction with anhydrous hydrogen fluoride in an inert solvent in a manner such that said anhydrous hydrogen fluoride is added to said phosphorus compound at a rate such that said anhydrous hydrogen fluoride reacts with said phosphorus compound without the accumulation of an amount of unreacted anhy­drous hydrogen fluoride which is sufficient to cause substantial decomposition of the desired fluorophosphorus product.

  至少有一个氯、溴或碘直接与磷键合的磷化合物，通过在惰性溶剂中与无水氟化氢反应，用氟进行反卤化，反应的方式是将所述无水氟化氢加入到所述磷化合物中，加入的速度使所述无水氟化氢与所述磷化合物反应，而不会积累一定量的未反应的无水氟化氢，足以导致所需的氟磷产品的大量分解。