3-O-[5-(3-maleimidopropionamido)pentyl]-carbamoyl-D-myo-inositol-1-phosphate | 889658-95-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-O-[5-(3-maleimidopropionamido)pentyl]-carbamoyl-D-myo-inositol-1-phosphate
• 英文别名: [(1R,2S,3S,4R,5S,6R)-2,3,4,6-tetrahydroxy-5-phosphonooxycyclohexyl] N-[5-[3-(2,5-dioxopyrrol-1-yl)propanoylamino]pentyl]carbamate
• CAS: 889658-95-1
• 化学式: C₁₉H₃₀N₃O₁₃P
• 分子量: 539.433
• InChiKey: ZCAUQQGLSWYIOW-MNWMBMHPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.8
• 重原子数：
  36
• 可旋转键数：
  13
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  253
• 氢给体数：
  8
• 氢受体数：
  13

反应信息

• 作为产物：
  描述：

  5-氨基戊基氨基甲酸苄酯 在 palladium 10% on activated carbon 氢气 作用下， 以 乙醇 、 水 、 N,N-二甲基甲酰胺 、 乙腈 为溶剂， 反应 55.08h， 生成 3-O-[5-(3-maleimidopropionamido)pentyl]-carbamoyl-D-myo-inositol-1-phosphate
  参考文献：
  名称：

  Inositol-phosphate derivatives and method of detecting inositol-1-phosphate

  摘要：

  本发明涉及肌醇磷酸衍生物，其中肌醇磷酸被一个或两个反应基团G或一个或两个共轭物质或分子M取代，所述反应基团G或所述物质或分子M通过连接基团L与IP1相连，M选择自以下组：示踪剂、免疫原、结合伙伴对的成员、固体支持。应用：工具，允许研究肌醇磷酸循环，因此间接地研究与磷脂酶C偶联的七膜跨膜结构受体、具有酪氨酸激酶活性的受体，以及一般参与细胞内IP1浓度变化的酶。

  公开号：

  US08178704B2

文献信息

• Inositol-Phosphate Derivatives and Method of Detecting Inositol-1-Phosphate
  申请人：Bazin Herve

  公开号：US20080261237A1

  公开（公告）日：2008-10-23

  The present invention relates to inositol phosphate derivatives, in which the inositol phosphate is substituted with one or two reactive groups G or one or two conjugated substances or molecules M, said reactive group(s) G or said substance(s) or molecule(s) M being linked to IP1 via a linkage group L, M being chosen from the following group: a tracer, an immunogen, a member of a binding partner pair, a solid support. Application: tools allowing the study of the inositol phosphate cycle and therefore, indirectly, the study of seven transmembrane domain receptors coupled to phospholipase C, receptors having a tyrosine kinase activity, and in general enzymes involved in the variations of the intracellular concentration of IP1.
• US8178704B2
  申请人：——

  公开号：US8178704B2

  公开（公告）日：2012-05-15
• Inositol-phosphate derivatives and method of detecting inositol-1-phosphate
  申请人：CIS Bio International

  公开号：US08178704B2

  公开（公告）日：2012-05-15

  The present invention relates to inositol phosphate derivatives, in which the inositol phosphate is substituted with one or two reactive groups G or one or two conjugated substances or molecules M, said reactive group(s) G or said substance(s) or molecule(s) M being linked to IP1 via a linkage group L, M being chosen from the following group: a tracer, an immunogen, a member of a binding partner pair, a solid support. Application: tools allowing the study of the inositol phosphate cycle and therefore, indirectly, the study of seven transmembrane domain receptors coupled to phospholipase C, receptors having a tyrosine kinase activity, and in general enzymes involved in the variations of the intracellular concentration of IP1.

  本发明涉及肌醇磷酸衍生物，其中肌醇磷酸被一个或两个反应基团G或一个或两个共轭物质或分子M取代，所述反应基团G或所述物质或分子M通过连接基团L与IP1相连，M选择自以下组：示踪剂、免疫原、结合伙伴对的成员、固体支持。应用：工具，允许研究肌醇磷酸循环，因此间接地研究与磷脂酶C偶联的七膜跨膜结构受体、具有酪氨酸激酶活性的受体，以及一般参与细胞内IP1浓度变化的酶。