(E)-3-[4-(pyridin-3-ylmethyl)phenyl]allyl alcohol | 103573-88-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂醇
• 英文名称: (E)-3-[4-(pyridin-3-ylmethyl)phenyl]allyl alcohol
• 英文别名: 3-{4-(3-pyridylmethyl)phenyl}-2-propen-1-ol；(E)-3-[4-(pyridin-3-ylmethyl)phenyl]prop-2-en-1-ol
• CAS: 103573-88-2
• 化学式: C₁₅H₁₅NO
• 分子量: 225.29
• InChiKey: WAGGPMFFXBMQIQ-DUXPYHPUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  33.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (E)-3-[4-(pyridin-3-ylmethyl)phenyl]allyl alcohol 在 氯化亚砜 作用下， 以 二氯甲烷 为溶剂， 生成 (E)-3-[4-(pyridin-3-ylmethyl)phenyl]allyl chloride hydrochloride
  参考文献：
  名称：

  Pyridyl ester containing 1,4-dihydropyridine derivatives and salts

  摘要：

  本发明涉及一种新型1,4-二氢吡啶衍生物，其化学式为##STR1##其中R2为吡啶基或其盐。这些化合物具有扩血管活性和抑制血小板聚集活性。本发明还揭示了含有这些化合物的药物组合物。

  公开号：

  US04731370A1
• 作为产物：
  描述：

  (E)-3-[4-(pyridin-3-ylmethyl)phenyl]acrylic acid ethyl ester 生成 (E)-3-[4-(pyridin-3-ylmethyl)phenyl]allyl alcohol
  参考文献：
  名称：

  WATANABE, ISAO;MOMONOI, KAISHU;HIRAIWA, TORU;ONO, SATOSHI;NAKANO, JOJI;NA+

  摘要：

  DOI：

文献信息

• 1,4-Dihydropyridine derivatives
  申请人：FUJIREBIO INC.

  公开号：EP0320984A3

  公开（公告）日：1989-12-27

  1,4-Dihydropyridine derivatives of the formula (I) having vasodilative activity and inhibitory activity on platelet aggregation: wherein Ar¹ represents an aromatic hydrocarbon group or heterocyclic group which may have at least one substituent; R¹ represents a hydrocarbon group which may have at least one substituent; A and B each represent a hydrocarbon group which may have at least one substituent, in which any of the carbon atoms in the main chain thereof may be replaced by a nitrogen atom or an oxygen atom; Ar² represents an aromatic hydrocarbon group or heterocyclic group; Ar³ represents a heterocyclic group which may have at least one substituent; and n is 0 or 1.

  具有扩血管活性和抑制血小板聚集活性的式(I)的1,4-二氢吡啶衍生物： 其中Ar¹代表一个芳香烃基或杂环基，可能具有至少一个取代基；R¹代表一个可能具有至少一个取代基的碳氢基团；A和B分别代表一个可能具有至少一个取代基的碳氢基团，在其中主链的任何碳原子可以被氮原子或氧原子取代；Ar²代表一个芳香烃基或杂环基；Ar³代表一个可能具有至少一个取代基的杂环基；n为0或1。
• Vasodilating and platelet aggregation inhibiting 1,4 dihydropyridines
  申请人：Toyama Chemical Co., Ltd.

  公开号：US04713387A1

  公开（公告）日：1987-12-15

  This invention relates to a 1,4-dihydropyridine derivative of the formula ##STR1## wherein Y represents an oxygen or sulfur atom or a vinylene group, Z represents an oxygen or sulfur atom or an alkylene group, R.sup.2 represents an imidazolyl or pyridyl group and the remaining substituents are herein defined. These compounds have a vasodilating activity and a platelet aggregation inhibiting activity.

  本发明涉及一种1，4-二氢吡啶衍生物，其化学式为##STR1##其中，Y代表氧原子或硫原子或乙烯基，Z代表氧原子或硫原子或烷基，R.sup.2代表咪唑基或吡啶基，其余的取代基在此定义。这些化合物具有扩血管作用和抑制血小板聚集的作用。
• 1,4-dihydropyridine derivatives
  申请人：Fujirebio Kabushiki Kaisha

  公开号：US05286869A1

  公开（公告）日：1994-02-15

  1,4-Dihydropyridine derivatives of formula: ##STR1## wherein Ar.sup.1 represents an aromatic hydrocarbon group or an aromatic heteromonocyclic or heterobicyclic group containing therein 1 to 3 atoms selected from the group consisting of oxygen, sulfur and nitrogen; R.sup.1 represents a hydrocarbon group which may have one or more substituents; A represents (i) a straight chain or branched chain unsaturated hydrocarbon group, (ii) a cyclic unsaturated hydrocarbon group, or (iii) a group selected from the group consisting of --R--O--N.dbd.CH--, --R--N.dbd.N--, --R--CH.dbd.N-- and --R--N.dbd.CH--, in which R is an alkylene group having 1 to 6 carbon atoms; B represents an alkylene or alkenylene group having 1 to 3 carbon atoms, which may have a substituent; Ar.sup.2 represents an aromatic hydrocarbon group or a heterocyclic group; Ar.sup.3 represents a heterocyclic group which may have one or more substituents; and n is 0 or 1, and the corresponding optical active 1,4-dihydropyridine derivatives, having an optically active cite as indicated by *, have both superior vasodilative and platelet aggregation inhibiting activities.

  公式为： ##STR1## 其中，Ar.sup.1表示芳香族烃基或含有氧、硫和氮元素中的1至3个的芳香族杂单环或杂双环基团；R.sup.1表示一个烃基，可以有一个或多个取代基；A表示（i）一条直链或支链不饱和烃基，（ii）一个环状不饱和烃基，或（iii）从--R--O--N.dbd.CH--，--R--N.dbd.N--，--R--CH.dbd.N--和--R--N.dbd.CH--中选择的一种基团，其中R是具有1至6个碳原子的烷基；B表示一个具有1至3个碳原子的烷基或烯基，可以有一个取代基；Ar.sup.2表示一个芳香族烃基或一个杂环基团；Ar.sup.3表示一个杂环基团，可以有一个或多个取代基；n为0或1，相应的光学活性1,4-二氢吡啶衍生物，具有如*所示的光学活性位点，具有卓越的血管扩张和抑制血小板聚集活性。
• Optical active 1,4-dihydropyridine derivates
  申请人：FUJIREBIO INC.

  公开号：EP0403957A2

  公开（公告）日：1990-12-27

  Optical active 1,4-dihydropyridine derivatives of formula: wherein Ar¹ represents an aromatic hydrocarbon group or an aromatic heteromonocyclic or heterobicyclic group containing therein 1 to 3 atoms selected from the group consisting of oxygen, sulfur and nitrogen; R¹ represents a hydrocarbon group which may have one or more substituents; A represents (i) a straight chain or branched chain unsaturated hydrocarbon group, (ii) a cyclic unsaturated hydrocarbon group, or (iii) a group selected from the group consisting of -R-O-N=CH-, -R-N=N-, -R-CH=N- and -R-N=CH-, in which R is an alkylene group having 1 to 6 carbon atoms; B represents an alkylene or alkenylene group having 1 to 3 carbon atoms, which may have a substituent; Ar² represents an aromatic hydrocarbon group or a heterocyclic group; Ar³ represents a heterocyclic group which may have one or more substituents; and n is 0 or 1, and * indicates an optically active cite.

  式中具有光学活性的 1,4-二氢吡啶衍生物： 其中 Ar¹ 代表芳香烃基团或芳香杂单环基团或杂环基团，其中包含 1 至 3 个原子，这些原子选自由氧、硫和氮组成的组；R¹ 代表烃基团，可以有一个或多个取代基；A 代表(i)直链或支链不饱和烃基，(ii)环状不饱和烃基，或(iii)选自-R-O-N=CH-、-R-N=N-、-R-CH=N-和-R-N=CH-的基团，其中 R 是具有 1 至 6 个碳原子的亚烷基；Ar² 代表芳香烃基团或杂环基团；Ar³ 代表杂环基团，可带有一个或多个取代基；n 为 0 或 1，* 表示光学活性引物。
• IKAVA, XIROSI;TSUNOIRI, AKITO;KOBAYASI, NOBUO;YAMAURA, TEHTSUAKI;KASEH, N+
  作者：IKAVA, XIROSI、TSUNOIRI, AKITO、KOBAYASI, NOBUO、YAMAURA, TEHTSUAKI、KASEH, N+

  DOI：——

  日期：——