2-methyl-4-iodoacetophenone | 52164-27-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-methyl-4-iodoacetophenone
• 英文别名: 4-Iod-2-methylacetophenon；1-(4-iodo-2-methyl-phenyl)-ethanone；1-(4-Jod-2-methyl-phenyl)-aethanon；1-(4-Iodo-2-methylphenyl)-1-ethanone；2-Acetyl-5-iodotoluene；1-(4-Iodo-2-methylphenyl)ethanone
• CAS: 52164-27-9
• 化学式: C₉H₉IO
• 分子量: 260.074
• InChiKey: HXTNKWJFMRPNEZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-methyl-4-iodoacetophenone 在 copper(l) iodide 、 potassium carbonate 、 氯磷酸二乙酯 、 二异丙胺 、 三苯基膦 、 bis(dibenzylideneacetone)-palladium⁽⁰⁾ 、 lithium diisopropyl amide 作用下， 以 四氢呋喃 、 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 7.75h， 生成 Tert-butyl-[2-[4-[2-(4-ethynyl-3-methylphenyl)ethynyl]phenyl]sulfanylethyl]-dimethylsilane
  参考文献：
  名称：

  Soluble Ferrocene Conjugates for Incorporation into Self-Assembled Monolayers

  摘要：

  A series of phenylethynyl oligomers (I-V) possessing a ferrocene and thiol at each termini have been synthesized. These oligomers have been designed to overcome the inherent insolubility of this class of complexes by substitution at the phenyl groups with methyl and propoxy substituents. Several new reactions for preparing arenethiol-protected compounds are described. Interestingly, the generation of an arenethiol anion during base- or fluoride-catalyzed deprotection has been characterized.

  DOI：

  10.1021/jo982392m
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 硫酸 、 水 、 potassium iodide 作用下， 生成 2-methyl-4-iodoacetophenone
  参考文献：
  名称：

  Estrogenic Biphenyls. IV. 3′-Alkyl-4-methoxybiphenyl-4′-carboxylic Acids

  摘要：

  DOI：

  10.1246/bcsj.30.958

文献信息

• Doxepin analogs and methods of use thereof
  申请人：Edgar M. Dale

  公开号：US20050143348A1

  公开（公告）日：2005-06-30

  The invention relates to novel antihistamines and methods of modulating sleep by administering a doxepin analog or a pharmaceutically effective salt thereof.

  这项发明涉及新型抗组胺药物和通过给予多塞平类似物或其药效盐来调节睡眠的方法。
• Methods of attaching conductive oligomers to electrodes
  申请人：Clinical Micro Sensors, Inc.

  公开号：US06090933A1

  公开（公告）日：2000-07-18

  The invention relates to nucleic acids covalently coupled to electrodes via conductive oligomers. More particularly, the invention is directed to the site-selective modification of nucleic acids with electron transfer moieties and electrodes to produce a new class of biomaterials, and to methods of making and using them.

  本发明涉及通过导电寡聚物与电极共价耦合的核酸。更具体地，本发明涉及通过电子转移基团和电极对核酸进行位点选择性修饰，以产生一种新型生物材料的方法，并涉及制备和使用这些材料的方法。
• Electrodes linked via oligomers to nucleic acids
  申请人：Kayyem F. Jon

  公开号：US20060099631A1

  公开（公告）日：2006-05-11

  The invention relates to nucleic acids covalently coupled to electrodes via conductive oligomers. More particularly, the invention is directed to the site-selective modification of nucleic acids with electron transfer moieties and electrodes to produce a new class of biomaterials, and to methods of making and using them.

  本发明涉及通过导电寡聚物与电极共价耦合的核酸。更具体地说，本发明涉及通过电子转移基团和电极的位点选择性修饰核酸，以产生一种新的生物材料类别，并提供制备和使用它们的方法。
• Electrodes linked via conductive oligomers to nucleic acids
  申请人：Clinical Micro Sensors, Inc.

  公开号：US20030003473A1

  公开（公告）日：2003-01-02

  The invention relates to nucleic acids covalently coupled to electrodes via conductive oligomers. More particularly, the invention is directed to the site-selective modification of nucleic acids with electron transfer moieties and electrodes to produce a new class of biomaterials, and to methods of making and using them.

  本发明涉及通过导电寡聚物与电极共价耦合的核酸。更具体地，本发明涉及将电子转移基团和电极与核酸进行位点选择性修饰，从而产生一种新的生物材料类别，以及制备和使用它们的方法。
• AC methods for the detection of nucleic acids
  申请人：——

  公开号：US20030148328A1

  公开（公告）日：2003-08-07

  The invention relates to nucleic acids covalently coupled to electrodes via conductive oligomers. More particularly, the invention is directed to the site-selective modification of nucleic acids with electron transfer moieties and electrodes to produce a new class of biomaterials, and to methods of making and using them.

  该发明涉及将核酸通过导电寡聚物与电极共价耦合。更具体地说，该发明旨在通过电子转移基团和电极对核酸进行位点选择性修饰，以产生一类新的生物材料，并提供制备和使用它们的方法。