6-formyl-2-(3-methoxy-6-pyridin-4-yl-pyridazin-4-yl)-indole-1-carboxylic acid tert-butyl ester | 869852-35-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 6-formyl-2-(3-methoxy-6-pyridin-4-yl-pyridazin-4-yl)-indole-1-carboxylic acid tert-butyl ester
• 英文别名: 6-Formyl-2-(3-methoxy-6-pyridin-4-yl-pyridazin-4-yl)-indole-1-carboxylic acid tert-butyl ester；tert-butyl 6-formyl-2-(3-methoxy-6-pyridin-4-ylpyridazin-4-yl)indole-1-carboxylate
• CAS: 869852-35-7
• 化学式: C₂₄H₂₂N₄O₄
• 分子量: 430.463
• InChiKey: YMXCYVFHBBVUPN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  32
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  96.2
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  6-formyl-2-(3-methoxy-6-pyridin-4-yl-pyridazin-4-yl)-indole-1-carboxylic acid tert-butyl ester 在 四(三苯基膦)钯 potassium phosphate 、 N-碘代丁二酰亚胺 、 sodium methylate 、 三乙酰氧基硼氢化钠 、 溶剂黄146 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 、 水 、 丙酮 、 甲苯 为溶剂， 反应 9.08h， 生成 4-{6-methoxy-5-[6-(4-methyl-piperazin-1-ylmethyl)-3-phenyl-1H-indol-2-yl]-pyridazin-3-yl}-2,6-dimethyl-phenol
  参考文献：
  名称：

  [EN] PYRIDAZINONE DERIVATIVES, METHODS FOR PRODUCING THEM AND THEIR USE AS PHARMACEUTICALS
  [FR] DERIVES DE PYRIDAZINONE, PROCEDES DE PRODUCTION DE CES DERIVES ET LEUR UTILISATION COMME PHARMACEUTIQUES

  摘要：

  本发明涉及通式（I）所示的化合物，其中下文给出了取代基X、R1和R2的定义，以及它们的生理上可接受的盐，生产这些化合物的方法以及它们作为药物的用途。通式（I）这些化合物是激酶抑制剂，特别是激酶GSK-15 30（糖原合成酶激酶-3ß）的抑制剂。

  公开号：

  WO2005111018A1
• 作为产物：
  描述：

  6-Hydroxymethyl-2-(3-methoxy-6-pyridin-4-yl-pyridazin-4-yl)-indole-1-carboxylic acidtert-butyl ester 在 manganese dioxide 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 以1.63 g (82%) crude product is obtained的产率得到6-formyl-2-(3-methoxy-6-pyridin-4-yl-pyridazin-4-yl)-indole-1-carboxylic acid tert-butyl ester
  参考文献：
  名称：

  Pyridazinone kinase inhibitors

  摘要：

  公开了一种式子为I的化合物，其中X为，R2、R1、A、B、D、E、R9如此定义，可用于治疗癌症。

  公开号：

  US07968546B2

文献信息

• Novel pyridazinone derivatives as inhibitors of CDK2
  申请人：Aventis Pharma Deutschland GmbH

  公开号：EP1598348A1

  公开（公告）日：2005-11-23

  The present invention relates to compounds according to the general formula (I), with the definitions of the substituents X, R1 and R2 given below in the text, as well as their physiologically acceptable salts, methods for producing these compounds and their use as pharmaceuticals. These compounds are kinase inhibitors, in particular inhibitors of the kinase CDK2 (cyclin-dependent kinase 2)

  本发明涉及符合通式（I）的化合物，其中下文给出了取代基X、R1和R2的定义，以及它们的生理上可接受的盐，以及制备这些化合物的方法以及它们作为药物的用途。 这些化合物是激酶抑制剂，特别是激酶CDK2（细胞周期依赖性激酶2）的抑制剂。
• PYRIDAZINONE DERIVATIVES, METHODS FOR THEIR PRODUCTION AND THEIR USE AS PHARMACEUTICALS
  申请人：Hoelder Swen

  公开号：US20070088041A1

  公开（公告）日：2007-04-19

  The present invention relates to compounds according to the general formula (I), with the definitions of the substituents X, R 1 and R 2 given below in the text, as well as their physiologically acceptable salts, methods for producing these compounds and their use as pharmaceuticals. These compounds are kinase inhibitors, in particular inhibitors of the kinase GSK-3β(glycogen synthase kinase-3β).

  本发明涉及符合通式（I）的化合物，其中X，R1和R2的定义如下文所述，以及它们的生理学上可接受的盐，制备这些化合物的方法以及它们作为药物的用途。这些化合物是激酶抑制剂，特别是激酶GSK-3β（糖原合成酶激酶-3β）的抑制剂。
• Novel Pyridazinone Derivatives
  申请人：HOELDER Swen

  公开号：US20090130209A1

  公开（公告）日：2009-05-21

  Disclosed are compounds according to the general formula (I), where the definitions of the substituents X, R 1 and R 2 are detailed in the description, as well as their physiologically acceptable salts and solvate, methods for producing these compounds and their use as pharmaceuticals. These compounds are kinase inhibitors, in particular inhibitors of the kinase CDK2 (cyclin-dependent kinase 2).

  本发明涉及一般式（I）的化合物，其中取代基X、R1和R2的定义详见说明书，以及它们的生理上可接受的盐和溶剂化物，制备这些化合物的方法以及它们作为药物的用途。这些化合物是激酶抑制剂，特别是CDK2（依赖于细胞周期蛋白的激酶2）的抑制剂。
• Pyridazinone derivatives
  申请人：Aventis Pharma S.A.

  公开号：US07507734B2

  公开（公告）日：2009-03-24

  Disclosed are compounds according to the general formula (I), where the definitions of the substituents X, R1 and R2 are detailed in the description, as well as their physiologically acceptable salts and solvate, methods for producing these compounds and their use as pharmaceuticals. These compounds are kinase inhibitors, in particular inhibitors of the kinase CDK2 (cyclin-dependent kinase 2).

  本发明涉及一般式（I）的化合物，其中取代基X、R1和R2的定义详见说明书，以及它们的生理学上可接受的盐和溶剂化物，制备这些化合物的方法以及它们作为药物的用途。这些化合物是激酶抑制剂，特别是CDK2（依赖于细胞周期蛋白激酶2）的抑制剂。
• Pyridazinone derivatives, methods for their production and their use as pharmaceuticals
  申请人：Sanofi-Aventis Deutschland GmbH

  公开号：US07709466B2

  公开（公告）日：2010-05-04

  The present invention relates to pyridazinone compounds and their derivatives according to the general formula (I), with the substituents X, R1 and R2 defined herein, as well as their physiologically acceptable salts, methods for producing these compounds and their use as pharmaceuticals. These compounds are kinase inhibitors, in particular inhibitors of the kinase GSK-3β (glycogen synthase kinase-3β) which are useful in the treatment of neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, strokes, cranial and spinal traumas and peripheral neuropathies, obesity, metabolic diseases, type II diabetes, essential hypertension, atherosclerotic cardiovascular diseases, polycystic ovary syndrome and syndrome X or immunodeficiency.

  本发明涉及吡啶并咪唑酮化合物及其衍生物，其通式（I）中的取代基X，R1和R2的定义，以及其生理上可接受的盐，制备这些化合物的方法以及它们作为药物的用途。这些化合物是激酶抑制剂，特别是激酶GSK-3β（糖原合成酶激酶-3β）的抑制剂，可用于治疗神经退行性疾病，如阿尔茨海默病，帕金森病，中风，头部和脊柱创伤和周围神经病变，肥胖症，代谢性疾病，2型糖尿病，高血压，动脉粥样硬化心血管疾病，多囊卵巢综合症和X综合症或免疫缺陷病。