1-(2,4-二硝基苯基)乙酮 | 62572-86-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 1-(2,4-二硝基苯基)乙酮
• 英文名称: 1-(2,4-dinitrophenyl)ethanone
• 英文别名: 1-(2,4-Dinitrophenyl)ethan-1-one
• CAS: 62572-86-5
• 化学式: C₈H₆N₂O₅
• 分子量: 210.146
• InChiKey: PMQDFKPCHUGQCY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  109
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  1-(2,4-二硝基苯基)乙酮 在 吡啶 、 盐酸 、 tin(II) chloride dihydrate 、 盐酸羟胺 、 sodium hydride 作用下， 以 乙醇 、 二乙二醇二甲醚 、 水 为溶剂， 反应 13.0h， 生成 3-甲基苯并[d]异噁唑-6-胺
  参考文献：
  名称：

  Bicyclic heterocyclic anthranilic diamides as ryanodine receptor modulators with insecticidal activity

  摘要：

  The diamide insecticides act on the ryanodine receptor (RyR). The synthesis of various bicyclic anthranilic derivatives is reported. Their activity against the insect ryanodine receptor (RyR) and their insecticidal activity in the greenhouse is presented, as well as structure activity relationship considerations. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2015.11.035
• 作为产物：
  描述：

  2,4-二硝基乙苯 在 硫酸 、 sodium t-butanolate 、 叔丁醇 作用下， 生成 1-(2,4-二硝基苯基)乙酮
  参考文献：
  名称：

  140.邻和对硝基苯乙酮的制备

  摘要：

  DOI：

  10.1039/jr9460000679

文献信息

• PYRAZOLOQUINOLONE DERIVATIVE AND USE THEREOF
  申请人：Takeda Pharmaceutical Company Limited

  公开号：EP1719771A1

  公开（公告）日：2006-11-08

  The present invention provides a pyarzoloquinolone derivative having kinase inhibitory activity. The derivative is represented by the formula: wherein R1 is an aryl group which may be substituted, or an aromatic heterocyclic group which may be substituted; R2 is a hydrogen atom, an amino group which may be substituted, a hydroxy group which may be substituted, or a thiol group which may be substituted; R3, R4, R5 and R6, which may be identical or different, are each (1) a hydrogen atom, (2) a nitro group, (3) a cyano group, (4) a halogen atom, (5) a hydrocarbon group which may be substituted, (6) an amino group which may be substituted, (7) a hydroxy group which may be substituted, or (8) a thiol group which may be substituted; and R3 and R4, R4 and R5, and R5 and R6 may respectively form a ring together with the adjacent carbon atom, or salt thereof.

  本发明提供了一种具有激酶抑制活性的吡唑喹啉衍生物。该衍生物由以下式表示： 其中R1是可以被取代的芳基或可以被取代的芳香杂环基；R2是氢原子、可以被取代的氨基、可以被取代的羟基或可以被取代的硫基；R3、R4、R5和R6，可以相同也可以不同，分别是（1）氢原子、（2）硝基、（3）氰基、（4）卤原子、（5）可以被取代的碳氢基、（6）可以被取代的氨基、（7）可以被取代的羟基或（8）可以被取代的硫基；且R3和R4、R4和R5、以及R5和R6可以分别与相邻的碳原子形成环，或其盐。
• Palladium-Catalyzed Chelation-Assisted Aromatic C–H Nitration: Regiospecific Synthesis of Nitroarenes Free from the Effect of the Orientation Rules
  作者：Wei Zhang、Shaojie Lou、Yunkui Liu、Zhenyuan Xu

  DOI：10.1021/jo400594j

  日期：2013.6.21

  ortho-nitration of aryl C–H bond is described. A range of azaarenes such as 2-arylquinoxalines, pyridines, quinoline, and pyrazoles were nitrated with excellent chemo- and regioselectivity. Using the O-methyl oximyl group as a removable directing group, the regiospecific synthesis of a variety of o-nitro aryl ketones was achieved starting from aryl ketones via a three-step process involving the Pd-catalyzed

  描述了钯催化的螯合辅助芳基CH键的邻位硝化反应。一系列氮杂芳烃（例如2-芳基喹喔啉，吡啶，喹啉和吡唑）被硝化，具有出色的化学和区域选择性。使用ø -甲基肟基团为一个可移动定向基团，各种的区域专一性合成ø硝基芳基酮经由涉及三个步骤的方法来实现从开始芳基酮Pd催化的本位C-H键的-nitration作为关键步骤。机理研究支持在氧化条件下涉及Pd（（II / III）和/或Pd（II / IV）催化循环的银介导的自由基机理。
• Pyrazoloquinolone Derivative And Use Thereof
  申请人：Fukumoto Shojl

  公开号：US20070281963A1

  公开（公告）日：2007-12-06

  The present invention provides a pyarzoloquinolone derivative having kinase inhibitory activity. The derivative is represented by the formula: wherein R 1 is an aryl group which may be substituted, or an aromatic heterocyclic group which may be substituted; R 2 is a hydrogen atom, an amino group which may be substituted, a hydroxy group which may be substituted, or a thiol group which may be substituted; R 3 , R 4 , R 5 and R 6 , which may be identical or different, are each (1) a hydrogen atom, (2) a nitro group, (3) a cyano group, (4) a halogen atom, (5) a hydrocarbon group which may be substituted, (6) an amino group which may be substituted, (7) a hydroxy group which may be substituted, or (8) a thiol group which may be substituted; and R 3 and R 4 , R 4 and R 5 , and R 5 and R 6 may respectively form a ring together with the adjacent carbon atom, or salt thereof.

  本发明提供了一种具有激酶抑制活性的吡唑喹啉衍生物。该衍生物由以下公式表示：其中，R1是可以被取代的芳基或可以被取代的芳香杂环基；R2是氢原子，可以被取代的氨基，可以被取代的羟基或可以被取代的硫醇基；R3、R4、R5和R6可以相同也可以不同，分别是（1）氢原子，（2）硝基，（3）氰基，（4）卤原子，（5）可以被取代的碳氢基，（6）可以被取代的氨基，（7）可以被取代的羟基或（8）可以被取代的硫醇基；R3和R4，R4和R5，以及R5和R6可以分别与相邻的碳原子形成环，或其盐。
• Photosensitive material for electrophotography
  申请人：MITA INDUSTRIAL CO. LTD.

  公开号：EP0100581A2

  公开（公告）日：1984-02-15

  @ Disclosed in a photosensitive material for the electrophotography, which comprises a dispersion of a charge-generating pigment in a charge-transporting medium composed mainly of a polyvinyl carbazole resin, wherein a perylene pigment represented by the following general formula: wherein R, and R2 stand for a hydrogen atom or a substituted or unsubstituted alkyl or aryl group, is dispersed and incorporated as the charge-generating pigment in an amount of 1 to 40 parts by weight per 100 parts by weight of the polyvinyl carbazole resin and a halogeno-p-benzoquinone is further incorporated in an amount of 1 to 60 parts by weight per 100 parts by weight of the polyvinyl carbazole resin.

  @公开了一种用于电致发光的感光材料，它包括电荷发生颜料在主要由聚乙烯基咔唑树脂构成的电荷传输介质中的分散体，其中由以下通式表示的过烯烃颜料： 其中 R 和 R2 代表氢原子或取代或未取代的烷基或芳基，作为电荷发生颜料以每 100 份聚乙烯基咔唑树脂 1 至 40 份（重量比）的量分散和掺入，卤代对苯醌以每 100 份聚乙烯基咔唑树脂 1 至 60 份（重量比）的量进一步掺入。
• METHOD FOR PRODUCING AROMATIC AMINE COMPOUND
  申请人：Nissan Chemical Industries, Ltd.

  公开号：EP3246308A1

  公开（公告）日：2017-11-22

  To provide a novel method for simply and efficiently removing a Sn compound contained in a reaction liquid at the time of reducing an aromatic nitro compound as a starting material with stannous chloride to produce an aromatic amine compound. A method for producing an aromatic amine compound represented by the formula 2, which comprises reducing an aromatic nitro compound represented by the formula 1 (Ar is an aromatic group) with stannous chloride, wherein a reaction liquid obtained by reducing the aromatic nitro compound represented by the formula 1, is brought into contact with a mixed liquid containing a compound having a benzene ring and a potassium hydroxide aqueous solution to carry out liquid separation, and from the obtained organic layer, the aromatic amine compound represented by the formula 2 is obtained:

  提供一种新方法，用于在用氯化锡还原作为起始原料的芳香族硝基化合物以生产芳香族胺 化合物时，简单而有效地除去反应液中所含的 Sn 化合物。 一种生产式 2 所代表的芳香族胺化合物的方法，它包括用氯化亚锡还原式 1 所代表的芳香族硝基化合物（Ar 为芳香族基团），其中还原式 1 所代表的芳香族硝基化合物得到的反应液与含有苯环化合物和氢氧化钾水溶液的混合液接触，进行液体分离，从得到的有机层中得到式 2 所代表的芳香族胺化合物：