1-O-ethyl 5-O-methyl (4E)-4-benzylidene-2-methylpentanedioate | 1190601-66-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: 1-O-ethyl 5-O-methyl (4E)-4-benzylidene-2-methylpentanedioate
• CAS: 1190601-66-1
• 化学式: C₁₆H₂₀O₄
• 分子量: 276.332
• InChiKey: UWTZLBIHHRKXRB-SDNWHVSQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  20
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-allyl 2-ethyl 4-methyl (E)-5-phenylpent-4-ene-2,2,4-tricarboxylate 在 palladium diacetate 、 三苯基膦 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 2.0h， 生成 1-O-ethyl 5-O-methyl (4E)-4-benzylidene-2-methylpentanedioate 、 5-ethyl 1-methyl 2-benzylidene-4-methylenepentanedioate
  参考文献：
  名称：

  An expedient synthesis of 2,4,5-trisubstituted 1,4-pentadienes from Baylis–Hillman adducts via the Pd-catalyzed decarboxylation–elimination protocol

  摘要：

  We disclosed an efficient synthetic method of 2,4,5-trisubstituted 1,4-pentadienes from Baylis-Hillman adducts via the Pd-catalyzed decarboxylation-elimination protocol as the key step. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.06.142

文献信息

• Radical cascade-enabled synthesis of precision polymers with complex main-chain structures
  申请人：Trustees of Boston College

  公开号：US11186678B2

  公开（公告）日：2021-11-30

  Radical cascade reactions enabling sequence-controlled ring-closing polymerization and ring-opening polymerization for the controlled synthesis of polymers with complex main-chain structures are provided. Facile syntheses leading to low-strain macrocyclic monomers consisting of the ring-opening triggers and extended main-chain structures are also provided. The present disclosure further provides methods for excellent control over polymer molecular weights and molecular weight distributions and high chain-end fidelity allows for the preparation of polymeric systems with well-defined architectures. Further provided are the general nature of the radical cascade-triggered transformations in polymer chemistry, and its application to the synthesis of polymers with diverse main-chain structural motifs with tailored functions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

  本研究提供了可实现序列控制的开环聚合和开环聚合的自由基级联反应，用于受控合成具有复杂主链结构的聚合物。此外，还提供了简便的合成方法，从而获得由开环触发器和扩展主链结构组成的低应变大环单体。本公开进一步提供了对聚合物分子量和分子量分布进行出色控制的方法，高链端保真度使得制备具有明确结构的聚合物体系成为可能。此外，还提供了聚合物化学中自由基级联触发转化的一般性质，及其在合成具有定制功能的各种主链结构基团的聚合物中的应用。本摘要旨在作为在特定技术领域进行搜索的扫描工具，并非对本公开内容的限制。
• RADICAL CASCADE-ENABLED SYNTHESIS OF PRECISION POLYMERS WITH COMPLEX MAIN-CHAIN STRUCTURES
  申请人：Trustees of Boston College

  公开号：US20200216610A1

  公开（公告）日：2020-07-09

  Radical cascade reactions enabling sequence-controlled ring-closing polymerization and ring-opening polymerization for the controlled synthesis of polymers with complex main-chain structures are provided. Facile syntheses leading to low-strain macrocyclic monomers consisting of the ring-opening triggers and extended main-chain structures are also provided. The present disclosure further provides methods for excellent control over polymer molecular weights and molecular weight distributions and high chain-end fidelity allows for the preparation of polymeric systems with well-defined architectures. Further provided are the general nature of the radical cascade-triggered transformations in polymer chemistry, and its application to the synthesis of polymers with diverse main-chain structural motifs with tailored functions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.