(R)-6-(3-Iodo-propyl)-6-methyl-1,4-dioxa-spiro[4.5]decane | 209343-16-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (R)-6-(3-Iodo-propyl)-6-methyl-1,4-dioxa-spiro[4.5]decane
• CAS: 209343-16-8
• 化学式: C₁₂H₂₁IO₂
• 分子量: 324.202
• InChiKey: SLWKQBPKXNVVPM-LLVKDONJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.53
• 重原子数：
  15.0
• 可旋转键数：
  3.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  18.46
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  (R)-6-(3-Iodo-propyl)-6-methyl-1,4-dioxa-spiro[4.5]decane 在 盐酸 、 N,N-二甲基丙烯基脲 、 copper(l) iodide 作用下， 以 四氢呋喃 为溶剂， 生成
  参考文献：
  名称：

  Stereoselective synthesis of the core structure of the protein phosphatase inhibitor dysidiolide

  摘要：

  The core structure of the protein phosphatase inhibitor dysidiolide and analogs thereof were built up in high yields and with high diastereomer ratios by Diels-Alder reaction between an appropriate diene and an alpha,beta-unsaturated aldehyde. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(98)00702-3
• 作为产物：
  描述：

  (R)-methyl 3-(6-methyl-1,4-dioxaspiro[4.5]decan-6-yl)propanoate 在 咪唑 、 lithium aluminium tetrahydride 、 碘 、 三苯基膦 作用下， 生成 (R)-6-(3-Iodo-propyl)-6-methyl-1,4-dioxa-spiro[4.5]decane
  参考文献：
  名称：

  Stereoselective synthesis of the core structure of the protein phosphatase inhibitor dysidiolide

  摘要：

  The core structure of the protein phosphatase inhibitor dysidiolide and analogs thereof were built up in high yields and with high diastereomer ratios by Diels-Alder reaction between an appropriate diene and an alpha,beta-unsaturated aldehyde. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(98)00702-3