6-methylsulfanylquinolin-4-ol | 848128-86-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 6-methylsulfanylquinolin-4-ol
• 英文别名: 6-(methylthio)-4-quinolinol；6-(methylthio)quinolin-4-ol；6-methylsulfanyl-1H-quinolin-4-one
• CAS: 848128-86-9
• 化学式: C₁₀H₉NOS
• 分子量: 191.254
• InChiKey: UCNDOVWKKZWNRL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  6-methylsulfanylquinolin-4-ol 在 三氯氧磷 作用下， 反应 3.0h， 生成 4-chloro-6-(methylthio)quinoline
  参考文献：
  名称：

  Synthesis of ring-substituted 4-aminoquinolines and evaluation of their antimalarial activities

  摘要：

  A simple two-step synthesis method was used to make 51 B-ring-substituted 4-hydroxyquinolines allowing analysis of the effect of ring substitutions on inhibition of growth of chloroquine sensitive and resistant strains of Plasmodium falciparum, the dominant cause of malaria morbidity. Substituted quinoline rings other than the 7-chloroquinoline ring found in chloroquine were found to have significant activity against the drug-resistant strain of P. falciparum W2. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.12.037
• 作为产物：
  描述：

  4-氨基茴香硫醚 在 水 、 sodium hydroxide 作用下， 以 二苯醚 、 乙醇 为溶剂， 反应 79.0h， 生成 6-methylsulfanylquinolin-4-ol
  参考文献：
  名称：

  AMINO-QUINOLINES AS KINASE INHIBITORS

  摘要：

  公开号：

  EP2566477B1

文献信息

• Compounds and Methods of Treatment
  申请人：LACKEY Karen Elizabeth

  公开号：US20080234267A1

  公开（公告）日：2008-09-25

  A derivative, which is useful as a ret kinase inhibitor is described herein. The described invention also includes methods of using the same in the treatment of diseases mediated by inappropriate ret kinase activity.

  本文描述了一种作为Ret酪氨酸激酶抑制剂有用的衍生物。所述发明还包括使用相同物质治疗由不当的Ret酪氨酸激酶活性介导的疾病的方法。
• 1,8-NAPHTHYRIDINONE COMPOUNDS AND USES THEREOF
  申请人：GiraFpharma LLC

  公开号：US20190023702A1

  公开（公告）日：2019-01-24

  1,8-naphthyridinone compounds as modulators of an adenosine receptor are provided. The compounds may find use as therapeutic agents for the treatment of diseases mediated through a G-protein-coupled receptor signaling pathway and may find particular use in oncology.

  提供了作为腺苷受体调节剂的1,8-萘啶酮化合物。这些化合物可能作为治疗经由G蛋白偶联受体信号通路介导的疾病的治疗剂，并且可能在肿瘤学中发挥特定作用。
• HETEROCYCLIC COMPOUNDS AS ADENOSINE ANTAGONISTS
  申请人：NUVATION BIO INC.

  公开号：US20200231570A1

  公开（公告）日：2020-07-23

  Aminopyrazine compounds as modulators of an adenosine receptor are provided. The compounds may find use as therapeutic agents for the treatment of diseases mediated through a G-protein-coupled receptor signaling pathway and may find particular use in oncology.

  提供了氨基吡嗪化合物作为腺苷受体的调节剂。这些化合物可能作为治疗经由G蛋白偶联受体信号通路介导的疾病的治疗剂，并且可能在肿瘤学中发挥特定作用。
• Enantioselective synthesis of cyclic α-aminoboronates <i>via</i> copper-catalyzed dearomative borylation of 4-quinolinols
  作者：Ming Xu、Yizhao Ouyang、Linghua Wang、Shuai Zhang、Pengfei Li

  DOI：10.1039/d2cc00027j

  日期：——

  using a Cu(I)/(R,R)-Ph-BPE catalyst for efficient synthesis of unprecedented heterocyclic α-amino boronates, a new class of compounds potentially relevant to drug discovery, in generally excellent yields and enantioselectivities. The products were also useful intermediates for highly functionalized tetrahydroquinolines and cyclic α-aminoboronate derivatives.

  使用 Cu( I )/( R , R )-Ph-BPE 催化剂开发了 4-喹啉醇的高度对映选择性和区域选择性去芳基化硼酸化，用于高效合成前所未有的杂环 α-氨基硼酸盐，一类可能与药物相关的新型化合物发现，通常具有优异的产率和对映选择性。该产品也是高度官能化的四氢喹啉和环状α-氨基硼酸酯衍生物的有用中间体。
• 1,8-naphthyridinone compounds and uses thereof
  申请人：NUVATION BIO INC.

  公开号：US10793561B2

  公开（公告）日：2020-10-06

  1,8-naphthyridinone compounds as modulators of an adenosine receptor are provided. The compounds may find use as therapeutic agents for the treatment of diseases mediated through a G-protein-coupled receptor signaling pathway and may find particular use in oncology.

  本研究提供了作为腺苷受体调节剂的 1,8-萘啶酮化合物。这些化合物可用作治疗剂，用于治疗通过 G 蛋白偶联受体信号通路介导的疾病，尤其可用于肿瘤学。