3-phenyl-7-(2-phenyl-2-oxoethyl)-5,6-dihydroimidazo<2,1-b>thiazolium bromide | 117376-95-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-phenyl-7-(2-phenyl-2-oxoethyl)-5,6-dihydroimidazo<2,1-b>thiazolium bromide
• 英文别名: 7-(2-Oxo-2-phenylethyl)-3-phenyl-5,6-dihydroimidazo[2,1-b]thiazol-7-ium bromide；1-phenyl-2-(3-phenyl-5,6-dihydroimidazo[2,1-b][1,3]thiazol-4-ium-7-yl)ethanone;bromide
• CAS: 117376-95-1
• 化学式: Br*C₁₉H₁₇N₂OS
• 分子量: 401.327
• InChiKey: APCVLZMYNWOIPX-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  0.41
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  52.4
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-phenyl-7-(2-phenyl-2-oxoethyl)-5,6-dihydroimidazo<2,1-b>thiazolium bromide 、 二苯甲酰基乙炔 在 三乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 2.0h， 生成 (2Z,5Z)-6-(5,6,7-tribenzoyl-2,3-dihydro-1H-pyrrolo<1,2-a>imidazol-1-yl)-3-benzoyl-1-oxo-1,6-diphenyl-4-thiahexa-2,5-diene 、 (2E,5Z)-6-(5,6,7-tribenzoyl-2,3-dihydro-1H-pyrrolo<1,2-a>imidazol-1-yl)-3-benzoyl-1-oxo-1,6-diphenyl-4-thiahexa-2,5-diene
  参考文献：
  名称：

  1,3-Dipolar cycloaddition of 5,6-dihydroimidazo[2,1-b]thiazolium betaines

  摘要：

  5,6-Dihydroimidazo[2,1-b]thiazolium betaines were generated in situ from 3,7-disubstituted 5,6-dihydroimidazo[2,1-b]thiazolium bromides and triethylamine. The reaction of these imidazothiazolium betaines with acetylenic dipolarophiles, such as ethyl propiolate, dimethyl acetylenedicarboxylate, and dibenzoylacetylene, provided geometric cis,trans isomers containing 2,3-dihydro-1H-pyrrolo[1,2-a]imidazole. We have proposed a mechanism of this reaction that involves 1,3-dipolar cycloaddition, isomeric rearrangement, and then nucleophilic addition successively. The ratio of trans and cis isomers depended on the temperature and solvents. The stereoselectivity of trans isomers increased with increasing temperature and decreasing polarity of solvents.

  DOI：

  10.1021/jo00034a029
• 作为产物：
  描述：

  5,6-二氢-3-苯基咪唑并[2,1-b]噻唑 、 2-溴苯乙酮 以 丙酮 为溶剂， 反应 5.0h， 以97%的产率得到3-phenyl-7-(2-phenyl-2-oxoethyl)-5,6-dihydroimidazo<2,1-b>thiazolium bromide
  参考文献：
  名称：

  1,3-Dipolar cycloaddition of 5,6-dihydroimidazo[2,1-b]thiazolium betaines

  摘要：

  5,6-Dihydroimidazo[2,1-b]thiazolium betaines were generated in situ from 3,7-disubstituted 5,6-dihydroimidazo[2,1-b]thiazolium bromides and triethylamine. The reaction of these imidazothiazolium betaines with acetylenic dipolarophiles, such as ethyl propiolate, dimethyl acetylenedicarboxylate, and dibenzoylacetylene, provided geometric cis,trans isomers containing 2,3-dihydro-1H-pyrrolo[1,2-a]imidazole. We have proposed a mechanism of this reaction that involves 1,3-dipolar cycloaddition, isomeric rearrangement, and then nucleophilic addition successively. The ratio of trans and cis isomers depended on the temperature and solvents. The stereoselectivity of trans isomers increased with increasing temperature and decreasing polarity of solvents.

  DOI：

  10.1021/jo00034a029

文献信息

• INHIBITORS OF THAPSIGARGIN-INDUCED CELL DEATH
  申请人：REED John C.

  公开号：US20120245147A1

  公开（公告）日：2012-09-27

  Methods for screening for inhibitors of endoplasmic reticulum (ER) stress are provided. These methods involve the addition of thapsigargin, which induces ER stress, and a test agent to mammalian cells in multi-well plates. Cell survival can be readily monitored by measuring intracellular ATP content using a bioluminescent reagent. Screening a commercially available library of 50,000 compounds led to the identification of 93 hit compounds that were subjected to secondary assays to confirm their ability to rescue cells from thapsigargin-induced cell death.
• 1,3-Dipolar cycloaddition of 5,6-dihydroimidazo[2,1-b]thiazolium betaines
  作者：Dong Jin Kim、Kyung Ho Yoo、Sang Woo Park

  DOI：10.1021/jo00034a029

  日期：1992.4

  5,6-Dihydroimidazo[2,1-b]thiazolium betaines were generated in situ from 3,7-disubstituted 5,6-dihydroimidazo[2,1-b]thiazolium bromides and triethylamine. The reaction of these imidazothiazolium betaines with acetylenic dipolarophiles, such as ethyl propiolate, dimethyl acetylenedicarboxylate, and dibenzoylacetylene, provided geometric cis,trans isomers containing 2,3-dihydro-1H-pyrrolo[1,2-a]imidazole. We have proposed a mechanism of this reaction that involves 1,3-dipolar cycloaddition, isomeric rearrangement, and then nucleophilic addition successively. The ratio of trans and cis isomers depended on the temperature and solvents. The stereoselectivity of trans isomers increased with increasing temperature and decreasing polarity of solvents.