Cyclopentylglykolsaeure | 6053-71-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羟基酸及其衍生物
• 英文名称: Cyclopentylglykolsaeure
• 英文别名: 2-cyclopentyl-2-hydroxyacetic acid
• CAS: 6053-71-0
• 化学式: C₇H₁₂O₃
• mdl: MFCD16669022
• 分子量: 144.17
• InChiKey: WHZPPIIMQBJUHW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.857
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  Cyclopentylglykolsaeure 在 硫酸 、 lithium diethylamide 作用下， 反应 3.33h， 生成 7-phenyl-1,2,3,6,7,7a-hexahydro-5H-inden-5-one
  参考文献：
  名称：

  合成中不饱和羧酸的二烯二醇。通过不饱和羧酸的串联Michael-Dieckmann脱羧环化反应合成环己酮和多环酮。

  摘要：

  通过将无环和脂环式不饱和羧酸的二烯二醇锂串联加入相同或其他不饱和羧酸的锂盐中来制备取代的2-环己烯酮4至7和六氢萘二烯酮和六氢茚并酮13至18。

  DOI：

  10.1016/s0040-4020(01)86973-8
• 作为产物：
  描述：

  cyclopentylglyoxylsaeure 在 1,6-di-o-phosphonohex-2-ulofuranose 、 Bacillus stearothermophilus 、 三乙醇胺盐酸盐 、 还原型辅酶Ⅰ 作用下， 生成 Cyclopentylglykolsaeure
  参考文献：
  名称：

  An evaluation of the substrate specificity, and of its modification by site-directed mutagenesis, of the cloned L-lactate dehydrogenase from Bacillus stearothermophilus

  摘要：

  DOI：

  10.1021/ja00199a046

文献信息

• Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
  申请人：——

  公开号：US20020045747A1

  公开（公告）日：2002-04-18

  Disclosed are compounds which inhibit &bgr;-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits &bgr;-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

  公开了抑制β-淀粉样肽释放和/或其合成的化合物，因此可用于治疗阿尔茨海默病。还公开了包含抑制β-淀粉样肽释放和/或其合成的化合物的药物组合物，以及使用这些药物组合物预防性和治疗性治疗阿尔茨海默病的方法。
• Heterocyclic compounds, pharmaceutical compositions comprising same, and methods for inhibiting &bgr;-amyloid peptide release and/or its synthesis by use of such compounds
  申请人：Athena Neurosciences, Inc.

  公开号：US06506782B1

  公开（公告）日：2003-01-14

  Disclosed are compounds which inhibit &bgr;-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits &bgr;-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

  公开了抑制β-淀粉样肽释放和/或其合成的化合物，因此可用于治疗阿尔茨海默病。还公开了包含抑制β-淀粉样肽释放和/或其合成的化合物的药物组合物，以及使用这些药物组合物预防性和治疗性地治疗阿尔茨海默病的方法。
• Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting &bgr;-amyloid peptide release and/or its synthesis by use of such compounds
  申请人：Elan Pharmaceuticals, Inc.

  公开号：US06509331B1

  公开（公告）日：2003-01-21

  Disclosed are compounds which inhibit &bgr;-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits &bgr;-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

  公开了抑制β-淀粉样肽释放和/或其合成的化合物，因此可用于治疗阿尔茨海默病。还公开了包含抑制β-淀粉样肽释放和/或其合成的化合物的药物组合物，以及使用这些药物组合物预防性和治疗性地治疗阿尔茨海默病的方法。
• HYDROXYMETHYL-CARBOXAMIDO-SUBSTITUTED SILANE AND ITS USE FOR CURABLE, SILANE-TERMINATED POLYMERS
  申请人：SIKA TECHNOLOGY AG

  公开号：US20160159833A1

  公开（公告）日：2016-06-09

  Specific hydroxysilanes of formula (I), a method for the production thereof, the use thereof as a constituent of moisture-curing compositions, and silane-functional compounds produced therefrom, in particular silane-functional polymers and isocyanatosilanes. The hydrosilanes can be produced in a simple process with a high degree of purity and are storage-stable after production. Production from the reaction of lactides with aminosilanes is particularly advantageous. Hydroxysilane of formula (I), where n is 1 or 2.

  公式（I）的特定羟基硅烷，其生产方法，其用作湿固化组合物成分的用途，以及由此产生的硅烷官能化化合物，特别是硅烷官能化聚合物和异氰酸硅烷。这些氢硅烷可以通过简单的过程以高纯度生产，并且在生产后具有储存稳定性。从乳酸酯与氨基硅烷的反应中生产是特别有利的。公式（I）的羟基硅烷，其中n为1或2。
• Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting B-amyloid peptide release and/or its synthesis by use of such compounds
  申请人：——

  公开号：US20020173504A1

  公开（公告）日：2002-11-21

  Disclosed are compounds which inhibit &bgr;-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits &bgr;-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

  本发明涉及抑制&bgr;-淀粉样肽的释放和/或合成的化合物，因此具有治疗阿尔茨海默病的效用。还公开了包含抑制&bgr;-淀粉样肽释放和/或合成的化合物的药物组合物，以及使用这种药物组合物预防和治疗阿尔茨海默病的方法。