1,1'-diphenyl-2,2'-piperazine-1,4-diyl-bis-ethanone | 5443-06-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1,1'-diphenyl-2,2'-piperazine-1,4-diyl-bis-ethanone
• 英文别名: 1,1'-Diphenyl-2,2'-piperazin-1,4-diyl-bis-aethanon；2-(4-Phenacylpiperazin-1-yl)-1-phenylethanone
• CAS: 5443-06-1
• 化学式: C₂₀H₂₂N₂O₂
• mdl: MFCD01023980
• 分子量: 322.407
• InChiKey: JYZWZUZEXDJDHQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  40.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-溴苯乙酮 在 potassium carbonate 作用下， 以 四氢呋喃 、 乙腈 为溶剂， 生成 1,1'-diphenyl-2,2'-piperazine-1,4-diyl-bis-ethanone
  参考文献：
  名称：

  COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND USE THEREOF AS INHIBITORS OF RAN GTPase

  摘要：

  Compounds of general formula IA, IB and IC outlined below, including pharmaceutically acceptable salts, solvates and hydrates thereof. Such compounds and pharmaceutical compositions comprising them may be used in medical conditions involving Ran GTPase.

  公开号：

  US20230302030A1

文献信息

• [EN] COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND USE THEREOF AS INHIBITORS OF RAN GTPASE<br/>[FR] COMPOSÉS, COMPOSITIONS PHARMACEUTIQUES ET LEUR UTILISATION EN TANT QU'INHIBITEURS DE LA RAN GTPASE
  申请人：THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIV

  公开号：WO2019046931A1

  公开（公告）日：2019-03-14

  Compounds of general formula IA, IB and IC outlined below, including pharmaceutically acceptable salts, solvates and hydrates thereof. Such compounds and pharmaceutical compositions comprising them may be used in medical conditions involving Ran GTPase.

  以下概述了通式IA、IB和IC的化合物，包括其药用盐、溶剂合物和水合物。这些化合物和包含它们的药物组合物可用于涉及Ran GTP酶的医疗状况。
• Aralkyl formly-alkyl piperazine derivatives and their uses as a cerebral nerve protective agent
  申请人：Li Jianqi

  公开号：US20050153981A1

  公开（公告）日：2005-07-14

  Aralkyl formyl alkyl piperazine derivatives Pharmaceutical compositions comprising the same, and methods of using them as a neuroprotective agent. Pharmaceutical results indicate that these compounds have excellent neuroprotective activities and fewer side effects.

  阿拉基基甲酰基烷基哌嗪衍生物，包括它们的制药组合物，以及使用它们作为神经保护剂的方法。制药结果表明，这些化合物具有出色的神经保护活性和较少的副作用。
• ARALKYL FORMYL-ALKYL PIPERAZINE DERIVATIVES AND THEIR USES AS CEREBRAL NERVE PROTECTIVE AGENT
  申请人：Shanghai Institute of Pharmaceutical Industry

  公开号：EP1553092A1

  公开（公告）日：2005-07-13

  The invention relates to aralkyl formyl-alkyl piperazine derivatives, and the use of its comnositions in the manufacture of medicaments for preventing or treating cerebral ischemic apoplexy and nerve protection, acting as central system excitable amino acid (N-methy-D-aspartic acid) antagonists (NMDA). The pharmacological experiments show that they display favorable full or ischemic anti-apoplexy activity, nerve protective activity and low side effects.

  本发明涉及芳烷基甲酰基-烷基哌嗪衍生物，及其组合物在制造预防或治疗脑缺血昏厥和神经保护药物中的用途，作为中枢系统兴奋性氨基酸（N-甲基-D-天冬氨酸）拮抗剂（NMDA）。药理实验表明，它们具有良好的完全或缺血性抗脑溢血活性、神经保护活性和低副作用。
• ANTIMALARIALS.¹ SOME PIPERAZINE DERIVATIVES
  作者：ROBERT E. LUTZ、NEWTON H. SHEARER

  DOI：10.1021/jo01170a005

  日期：1947.11
• COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND USE THEREOF AS INHIBITORS OF RAN GTPASE
  申请人：THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING / MCGILL UNIVERSITY

  公开号：US20200246365A1

  公开（公告）日：2020-08-06

  Compounds of general formula IA, IB and IC outlined below, including pharmaceutically acceptable salts, solvates and hydrates thereof. Such compounds and pharmaceutical compositions comprising them may be used in medical conditions involving Ran GTPase.