5,5'-di(benzyliminomethyl)-BAPTA-tetraethyl ester | 475578-63-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 5,5'-di(benzyliminomethyl)-BAPTA-tetraethyl ester
• 英文别名: VK-178；ethyl 2-[4-(benzyliminomethyl)-2-[2-[5-(benzyliminomethyl)-2-[bis(2-ethoxy-2-oxoethyl)amino]phenoxy]ethoxy]-N-(2-ethoxy-2-oxoethyl)anilino]acetate
• CAS: 475578-63-3
• 化学式: C₄₆H₅₄N₄O₁₀
• 分子量: 822.956
• InChiKey: AEQWMXRHVCXAAZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.4
• 重原子数：
  60
• 可旋转键数：
  29
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  155
• 氢给体数：
  0
• 氢受体数：
  14

反应信息

• 作为反应物：
  描述：

  5,5'-di(benzyliminomethyl)-BAPTA-tetraethyl ester 在 二甲胺基甲硼烷 、 溶剂黄146 作用下， 反应 2.0h， 以34%的产率得到5,5'-di(benzylaminomethyl)-BAPTA-tetraethyl ester
  参考文献：
  名称：

  Ultralow Calcium Requirements of Fungi Facilitate Use of Calcium Regulating Agents to Suppress Host Calcium-Dependent Defenses, Synergizing Infection by a Mycoherbicide

  摘要：

  Infection by many fungi activates a variety of calcium dependent defenses in the hosts, slowing or suppressing the attacker and limiting the efficacy of mycoherbicides. The calcium requirement for fungal growth is so low that it could only be implied based on fungi containing calcium-dependent signaling enzymes. Analytical grade media contain <2 muM calcium, and the addition of specific chelators does not affect fungal growth. Hydrophobic derivatives of the calcium-specific chelator BAPTA designed to traverse plant cuticles were synthesized in order to chelate calcium internally during fungal attack. Some chelators as well as calcium precipitating oxalate and channel blocker verapamil were applied with a weakly mycoherbicidal Colletotrichum coccodes to cotyledons of compatible Abutilon threophrasti. They suppressed calcium dependent callose biosynthesis in the weed and increased virulence but may have affected other calcium-dependent processes that facilitate virulence. The low calcium requirement of fungi, and their high affinity for calcium, allows the application of calcium-regulating agents as synergists for mycoherbicides where the weed uses calcium-dependent defenses.

  DOI：

  10.1021/jf0201780
• 作为产物：
  描述：

  sodium o-nitrophenate 在 palladium on activated charcoal 吡啶 、 氢气 、 N,N-二异丙基乙胺 、 三氯氧磷 作用下， 以 乙醇 、 N,N-二甲基甲酰胺 、 甲苯 为溶剂， 反应 1.0h， 生成 5,5'-di(benzyliminomethyl)-BAPTA-tetraethyl ester
  参考文献：
  名称：

  Ultralow Calcium Requirements of Fungi Facilitate Use of Calcium Regulating Agents to Suppress Host Calcium-Dependent Defenses, Synergizing Infection by a Mycoherbicide

  摘要：

  Infection by many fungi activates a variety of calcium dependent defenses in the hosts, slowing or suppressing the attacker and limiting the efficacy of mycoherbicides. The calcium requirement for fungal growth is so low that it could only be implied based on fungi containing calcium-dependent signaling enzymes. Analytical grade media contain <2 muM calcium, and the addition of specific chelators does not affect fungal growth. Hydrophobic derivatives of the calcium-specific chelator BAPTA designed to traverse plant cuticles were synthesized in order to chelate calcium internally during fungal attack. Some chelators as well as calcium precipitating oxalate and channel blocker verapamil were applied with a weakly mycoherbicidal Colletotrichum coccodes to cotyledons of compatible Abutilon threophrasti. They suppressed calcium dependent callose biosynthesis in the weed and increased virulence but may have affected other calcium-dependent processes that facilitate virulence. The low calcium requirement of fungi, and their high affinity for calcium, allows the application of calcium-regulating agents as synergists for mycoherbicides where the weed uses calcium-dependent defenses.

  DOI：

  10.1021/jf0201780

文献信息

• Ultralow Calcium Requirements of Fungi Facilitate Use of Calcium Regulating Agents to Suppress Host Calcium-Dependent Defenses, Synergizing Infection by a Mycoherbicide
  作者：Jonathan Gressel、Daphna Michaeli、Vladimir Kampel、Ziva Amsellem、Abraham Warshawsky

  DOI：10.1021/jf0201780

  日期：2002.10.1

  Infection by many fungi activates a variety of calcium dependent defenses in the hosts, slowing or suppressing the attacker and limiting the efficacy of mycoherbicides. The calcium requirement for fungal growth is so low that it could only be implied based on fungi containing calcium-dependent signaling enzymes. Analytical grade media contain <2 muM calcium, and the addition of specific chelators does not affect fungal growth. Hydrophobic derivatives of the calcium-specific chelator BAPTA designed to traverse plant cuticles were synthesized in order to chelate calcium internally during fungal attack. Some chelators as well as calcium precipitating oxalate and channel blocker verapamil were applied with a weakly mycoherbicidal Colletotrichum coccodes to cotyledons of compatible Abutilon threophrasti. They suppressed calcium dependent callose biosynthesis in the weed and increased virulence but may have affected other calcium-dependent processes that facilitate virulence. The low calcium requirement of fungi, and their high affinity for calcium, allows the application of calcium-regulating agents as synergists for mycoherbicides where the weed uses calcium-dependent defenses.