1-hexyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid hydrazide | 148237-84-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1-hexyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid hydrazide
• 英文别名: 1-Hexyl-4-hydroxy-2-oxoquinoline-3-carbohydrazide
• CAS: 148237-84-7
• 化学式: C₁₆H₂₁N₃O₃
• 分子量: 303.361
• InChiKey: STWLMMJILFTYNH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.89
• 重原子数：
  22.0
• 可旋转键数：
  6.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  97.35
• 氢给体数：
  3.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  1-hexyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid hydrazide 反应 0.5h， 以87%的产率得到5-Hexyl-1,2-dihydropyrazolo[4,3-c]quinoline-3,4-dione
  参考文献：
  名称：

  4-Hydroxyquinolones-2

  摘要：

  DOI：

  10.1007/bf00531325
• 作为产物：
  描述：

  1-hexyl-3-ethoxycarbonyl-4-hydroxy-2(1H)-quinolinone 在 一水合肼 作用下， 生成 1-hexyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid hydrazide
  参考文献：
  名称：

  4-hydroxy-2-quinolones 165*. 1-R-4-hydroxy-2-oxo-1,2-dihydro-quinoline-3-carbaldehydes and their thiosemicarbazones. Synthesis, structure, and biological properties

  摘要：

  Two variants are discussed of the synthesis of 1-R-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid beta-N-tosylhydrazides which undergo a McFayden-Stevens reaction to give 1-R-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carbaldehydes in high yields. It was shown that the thiosemicarbazones prepared from them exist in the solid state exclusively in the syn-form while in solution a hydrazone. <-> enhydrazine tautomerism is observed. The results of a study of the antitubercular activity of the synthesized compounds are reported.

  DOI：

  10.1007/s10593-009-0327-2

文献信息

• 4-Hydroxy-2-quinolones 171*. Synthesis, isomerism, and antitubercular activity of 1-R-4-hydroxy-2-oxo-1,2-dihydro-quinoline-3-carboxylic acid alkylidenehydrazides
  作者：I. V. Ukrainets、Liu Yangyang、A. A. Tkach、A. V. Turov、O. S. Golovchenko

  DOI：10.1007/s10593-010-0431-3

  日期：2009.11

  Alkylidenehydrazides have been synthesized by the reaction of 1-R-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid hydrazides with lower dialkyl ketones in order to reveal a structure-antitubercular activity relationship. It was shown by H-1 NMR spectroscopy that hydrazones obtained from the unsymmetrical ketone-methyl ethyl ketone-exist primarily in the E-isomer form. It was found that the presence of two aliphatic substituents in the alkylidene fragment of the compounds investigated leads to a marked lowering of antimicobacterial properties.
• 4-Hydroxy-2-quinolones 132. Synthesis, chemical, and biological properties of 1-R-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acids 2-nitrobenzylidenehydrazides
  作者：I. V. Ukrainets、L. V. Sidorenko、O. S. Golovchenko

  DOI：10.1007/s10593-007-0221-8

  日期：2007.11