4-苯基-1-(4-哌啶基)-4-(4,5-二氢咪唑)-2-酮 | 205058-28-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: 4-苯基-1-(4-哌啶基)-4-(4,5-二氢咪唑)-2-酮
• 中文别名: 4-苯基-1-(4-哌啶基)-4基-1,3-二氢-2H-咪唑-2-酮
• 英文名称: 4-(1,3-dihydro-4-phenyl-2(2H)-oxoimidazol-1-yl)piperidine
• 英文别名: 4-phenyl-1-piperidin-4-yl-1,3-dihydro-imidazol-2-one；1,3-dihydro-1-(4-piperidinyl)-4-phenyl-2(2H)-imidazolone；1,3-dihydro-4-phenyl-1-(4-piperidinyl)-2H-imidazol-2-one；5-Phenyl-3-(piperidin-4-yl)-1H-imidazol-2(3H)-one；4-phenyl-1-piperidin-4-yl-1,3-dihydro-2H-imidazol-2-one；4-phenyl-1-(piperidin-4-yl)-1H-imidazol-2(3H)-one；4-phenyl-(piperidin-4-yl)-1H-imidazol-2(3H)-one；5-phenyl-3-piperidin-4-yl-1H-imidazol-2-one
• CAS: 205058-28-2
• 化学式: C₁₄H₁₇N₃O
• 分子量: 243.308
• InChiKey: OPCVKWIYGHICKG-UHFFFAOYSA-N

物化性质

• 熔点：
  235°C
• 稳定性/保质期：

  避氧化物

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  44.4
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 危险等级：
  IRRITANT
• 危险品标志：
  Xi
• 海关编码：
  2933990090

反应信息

• 作为反应物：
  描述：

  4-苯基-1-(4-哌啶基)-4-(4,5-二氢咪唑)-2-酮 在 三乙胺 、 3-(二乙氧基邻酰氧基)-1,2,3-苯并三嗪-4-酮 、 lithium hydroxide 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 生成 2-((7-methyl-1H-indazol-5-yl)methyl)-4-oxo-4-(4-(2-oxo-4-phenyl-2,3-dihydro-1H-imidazol-1-yl)piperidin-1-yl)butanoic acid
  参考文献：
  名称：

  Calcitonin gene-related peptide (CGRP) receptor antagonists: Novel aspartates and succinates

  摘要：

  Novel aspartate and succinate CGRP full antagonists were identified through core modification of a potent lead CGRP antagonist, BMS-694153. While aspartates were much less active and had a flat SAR, some of the succinates were very potent CGRP full antagonists and matched the potency of BMS-694153. The most potency resides in the S enantiomer as demonstrated through an asymmetric synthesis. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.02.066
• 作为产物：
  描述：

  4-(2-氧代-5-苯基-1,2-二氢咪唑-3-基)哌啶-1-羧酸叔丁酯 生成 4-苯基-1-(4-哌啶基)-4-(4,5-二氢咪唑)-2-酮
  参考文献：
  名称：

  Modified aminoacids, pharmaceuticals containing these compounds and method for their production

  摘要：

  本发明涉及一般式的改性氨基酸 其中 A、Z、X、n、m、R、R2、R3、R4和R11的定义如权利要求1至5中所述，它们的互变异构体、对映异构体、立体异构体、它们的混合物及其盐，特别是其与无机或有机酸或碱的生理上可接受的盐，含有这些化合物的药物组合物，其用途以及制备它们的过程，以及它们在抗体的生产和纯化中的用途以及在RIA和ELISA测定中作为标记化合物以及在神经递质研究中作为诊断或分析辅助工具的用途。

  公开号：

  US06344449B1

文献信息

• Constrained compounds as CGRP-receptor antagonists
  申请人：Chaturvedula V. Prasad

  公开号：US20060094707A1

  公开（公告）日：2006-05-04

  The invention encompasses constrained bicyclic and tricyclic CGRP-receptor antagonists, methods for identifying them, pharmaceutical compositions comprising them, and methods for their use in therapy for treatment of migraine and other headaches, neurogenic vasodilation, neurogenic inflammation, thermal injury, circulatory shock, flushing associated with menopause, airway inflammatory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), and other conditions the treatment of which can be effected by the antagonism of CGRP-receptors.

  这项发明涵盖了受限的双环和三环CGRP受体拮抗剂，用于识别它们的方法，包含它们的药物组合物，以及它们在治疗偏头痛和其他头痛、神经源性血管舒张、神经源性炎症、热损伤、循环性休克、与绝经期相关的潮红、气道炎症性疾病（如哮喘和慢性阻塞性肺病（COPD））以及其他可以通过CGRP受体拮抗来治疗的疾病的治疗方法。
• [EN] QUINAZOLINONE COMPOUNDS AND DERIVATIVES THEREOF<br/>[FR] COMPOSÉS QUINAZOLINONES ET LEURS DÉRIVÉS
  申请人：AMGEN INC

  公开号：WO2014036022A1

  公开（公告）日：2014-03-06

  Compounds of Formula I are useful inhibitors of tankyrase. Compounds of Formula I have the following structure: where the definitions of the variables are provided herein.

  公式I的化合物是坦克酶的有用抑制剂。公式I的化合物具有以下结构：其中变量的定义在此提供。
• Arylalkane, arylalkene and aryl azaalkane, medicaments containing said compounds and method for the production thereof
  申请人：Boehringer Ingelheim Pharma GmbH & Co. KG

  公开号：US07230001B1

  公开（公告）日：2007-06-12

  The present invention relates to compounds of general formula R—Z1—Z2—Z3—R1,   (I) wherein R, R1 and Z1 to Z3 are defined as in claim 1, the tautomers, the diastereomers, the enantiomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable pharmacological properties, particularly CGRP-antagonistic properties, pharmaceutical compositions containing these compounds, their use and processes for preparing them.

  本发明涉及一般式 R—Z1—Z2—Z3—R1，  (I) 其中 R、R1和Z1至Z3如权利要求1中所定义，其互变异构体、对映异构体、立体异构体、它们的混合物及其盐，特别是其与无机或有机酸或碱的生理上可接受的盐，具有有价值的药理特性，特别是CGRP拮抗特性，含有这些化合物的药物组合物，它们的用途和制备它们的方法。
• Modified amino acids, pharmaceuticals containing these compounds and method for their production
  申请人：——

  公开号：US20010036946A1

  公开（公告）日：2001-11-01

  The present invention relates to modified amino acids of general formula 1 wherein A, Z, X, n, m, R, R 2 , R 3 , R 4 and R 11 are defined as in claims 1 to 5 , their tautomers, their diastereomers, their enantiomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, pharmaceutical compositions containing these compounds, the use thereof and processes for preparing them as well as their use for the production and purification of antibodies and as labelled compounds in RIA- and ELISA assays and as diagnostic or analytical aids in neurotransmitter research.

  本发明涉及一般式1的改良氨基酸，其中A、Z、X、n、m、R、R2、R3、R4和R11如权利要求1至5中所定义，它们的互变异构体、对映异构体、混合物及其盐，特别是其与无机或有机酸或碱的生理上可接受的盐，含有这些化合物的药物组合物，其用途以及用于制备它们的过程，以及它们在抗体的生产和纯化中的用途，以及在RIA和ELISA测定中作为标记化合物以及在神经递质研究中作为诊断或分析辅助工具的用途。
• Antagonists of calcitonin gene-related peptide
  申请人：Boehringer Ingelheim Pharma KG

  公开号：US06313097B1

  公开（公告）日：2001-11-06

  Compounds of the formula (I) wherein A, R, R1, R2, X1, X2, X3, and Y are as defined herein, and the tautomers and the pharmaceutically acceptable salts thereof, including pharmaceutical compositions containing these compounds, and their use in the selective antagonization of calcitonin gene-related peptide (CGRP) and in the treatment or prophylaxis of migraine or cluster headaches, non-insulin-dependent diabetes mellitus, inflammation, allergic rhinitis, asthma, morphine tolerance, menopausal hot flashes, and diseases characterized by excessive vasodilatation and consequent reduction in blood-flow.

  式(I)的化合物，其中A、R、R1、R2、X1、X2、X3和Y的定义如本文所述，以及其互变异构体和药学上可接受的盐，包括含有这些化合物的药物组合物，以及它们在选择性拮抗降钙素基因相关肽（CGRP）和治疗或预防偏头痛或集群头痛、非胰岛素依赖型糖尿病、炎症、过敏性鼻炎、哮喘、吗啡耐受、绝经期潮热以及以过度血管扩张和随之血流减少为特征的疾病中的应用。