1,6-二(4-氟苯基)己烷-1,6-二酮 | 71825-34-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 1,6-二(4-氟苯基)己烷-1,6-二酮
• 英文名称: 1,6-bis(4-fluorophenyl)hexane-1,6-dione
• 英文别名: 1,4-Bis-(p-fluorbenzoyl)butan
• CAS: 71825-34-8
• 化学式: C₁₈H₁₆F₂O₂
• 分子量: 302.321
• InChiKey: DYKMRYGBFNIUPA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  22
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1,6-二(4-氟苯基)己烷-1,6-二酮 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 乙醚 为溶剂， 反应 13.0h， 生成 2,5-Bis(azepan-1-ylmethyl)-1,6-bis(4-fluorophenyl)hexane-1,6-diol
  参考文献：
  名称：

  1,6-Bisaryl-2,5-dihexyliminomethyl-1,6-hexanediones and their reduction products. The biological activity of their salts

  摘要：

  DOI：

  10.1007/bf00765025
• 作为产物：
  描述：

  1-(4-fluorophenyl)cyclopropan-1-ol 在 dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer 、 silver carbonate 作用下， 以 2,2,2-三氟乙醇 为溶剂， 反应 0.25h， 以55%的产率得到1,6-二(4-氟苯基)己烷-1,6-二酮
  参考文献：
  名称：

  Rhodium-Catalyzed Room Temperature C–C Activation of Cyclopropanol for One-Step Access to Diverse 1,6-Diketones

  摘要：

  A rhodium-catalyzed room temperature C-C activation of cyclopropanol has been demonstrated for the single-step synthesis of a range of electronically and sterically distinct 1,6-diketones. This reaction proceeds efficiently in shorter reaction time following a highly atom-economical pathway. To illustrate the synthetic potential of 1,6-diketones, aldol and macrocyclization reactions have been successfully demonstrated. Preliminary mechanistic studies revealed the involvement of nonradical pathways.

  DOI：

  10.1021/acs.orglett.0c00967

文献信息

• Potential antiinflammatory compounds. 1. Antiinflammatory phenylpiperidine derivatives
  作者：Terence A. Hicks、Christine E. Smith、W. R. Nigel Williamson、Elaine H. Day

  DOI：10.1021/jm00198a006

  日期：1979.12

  The syntheses of a number of amines and their derivatives, based on the phenylpiperidine nucleus, are described. Their activities on the rat paw carrageenan test are also reported. Activities comparable to that of phenylbutazone were obtained for some of the amines, notably 4-piperidino-beta-methylphenethylamine.

  描述了基于苯基哌啶核的许多胺及其衍生物的合成。还报道了它们在鼠爪角叉菜胶试验中的活性。对于某些胺，特别是4-哌啶子基-β-甲基苯乙胺，获得了与苯基丁a相当的活性。
• Polyimides with carbonyl and ether connecting groups between the
  申请人：The United States of America as represented by the Administrator of the

  公开号：US05145937A1

  公开（公告）日：1992-09-08

  New polyimides have been prepared from the reaction of aromatic dianhydrides with novel aromatic diamines containing carbonyl and ether connecting groups between the aromatic rings. Several of these polyimides were shown to be semi-crystalline as evidenced by wide angle x-ray diffraction and differential scanning calorimetry. Most of the polyimides form tough solvent resistant films with high tensile properties. Several of these materials can be thermally processed to form solvent and base resistant moldings.

  新的聚酰亚胺材料是通过芳香族二酸酐和含有芳香族环之间连接羰基和醚基的新型芳香族二胺反应制备而成。通过广角X射线衍射和差示扫描量热法，证明其中一些聚酰亚胺具有半晶态结构。大多数聚酰亚胺形成耐溶剂的坚韧膜，并具有高拉伸性能。其中数种材料可以经过热加工处理，形成耐溶剂和耐碱的模塑件。
• HICKS T. A.; SMITH C. E.; WILLIAMSON W. R. N.; DAY E. H., J. MED. CHEM., 1979, 22, NO 12, 1460-1464
  作者：HICKS T. A.、 SMITH C. E.、 WILLIAMSON W. R. N.、 DAY E. H.

  DOI：——

  日期：——
• PETROSYAN, L. M.;GEVORGYAN, G. A.;POGOSYAN, A. V.;MARKARYAN, K. ZH.;CHACH+, XIM. FARMATS. ZH., 1983, 17, N 10, 1208-1212
  作者：PETROSYAN, L. M.、GEVORGYAN, G. A.、POGOSYAN, A. V.、MARKARYAN, K. ZH.、CHACH+

  DOI：——

  日期：——
• US5145937A
  申请人：——

  公开号：US5145937A

  公开（公告）日：1992-09-08