EHT1864 | 754239-64-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: EHT1864
• 英文别名: 2-(Morpholin-4-ylmethyl)-5-[5-[7-(trifluoromethyl)quinolin-4-yl]sulfanylpentoxy]pyran-4-one
• CAS: 754239-64-0
• 化学式: C₂₅H₂₇F₃N₂O₄S
• 分子量: 508.562
• InChiKey: MIDUFIRTIFUTQA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  35
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  86.2
• 氢给体数：
  0
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  EHT1864 在 盐酸 作用下， 以 乙醇 为溶剂， 反应 2.0h， 以58%的产率得到5-[(5-{[7-(trifluoromethyl)quinolin-4-yl]sulfanyl}pentyl)oxy]-2-[(morpholin-4-yl)methyl]-4H-pyran-4-one dihydrochloride
  参考文献：
  名称：

  Methods of treating nervous disorders

  摘要：

  这项发明涉及治疗神经紊乱的组合物和方法。更具体地说，这项发明涉及使用Rac1抑制剂治疗淀粉样β肽相关疾病，尤其是阿尔茨海默病的方法。这项发明可以在哺乳动物主体，尤其是人类主体的各个疾病阶段中使用，包括疾病发作阶段。该发明还提供了一种根据测试化合物抑制Rac1的能力确定生产、鉴定、选择或优化用于治疗淀粉样β肽相关疾病的化合物的方法。

  公开号：

  US20070027146A1
• 作为产物：
  描述：

  5-(5-bromo-pentyloxy)-2-(tert-butyl-dimethyl-silanyloxymethyl)-4H-pyran-4-one 在 四丁基氟化铵 、 sodium hydride 、 三乙胺 作用下， 以 四氢呋喃 、 DMF (N,N-dimethyl-formamide) 、 二氯甲烷 为溶剂， 反应 25.17h， 生成 EHT1864
  参考文献：
  名称：

  [EN] COMPOUNDS AND METHODS OF TREATING CELL PROLIFERATIVE DISEASES, RETINOPATHIES AND ARTHRITIS
  [FR] NOUVEAUX COMPOSES ET PROCEDES DE TRAITEMENT DE PATHOLOGIES ASSOCIEES A LA PROLIFERATION CELLULAIRE, DE RETINOPATHIES ET DE L'ARTHRITE

  摘要：

  公开号：

  WO2004076445A3

文献信息

• Novel compounds and methods of treating cell proliferative diseases, retinopathies and arthritis
  申请人：Leblond Bertrand

  公开号：US20060183749A1

  公开（公告）日：2006-08-17

  The present invention relates to compounds and their uses, particularly in the pharmaceutical industry. The invention discloses compounds having anti-proliferative and antiangiogenic activities, as well as methods for treating various diseases associated with abnormal cell proliferation, including cancer, or associated with unregulated angiogenesis including growth and metastasis of solid tumors, ocular diseases and especially retinopathies, or arthritis, by administering said compounds. It further deals with pharmaceutical compositions comprising said compounds, more particularly useful to treat cancers (such as leukemia), ocular diseases and arthritis.

  本发明涉及化合物及其用途，特别是在制药工业中的应用。该发明揭示了具有抗增殖和抗血管生成活性的化合物，以及治疗与异常细胞增殖相关的各种疾病的方法，包括癌症，或与非调节性血管生成相关的疾病，包括实体肿瘤的生长和转移、眼部疾病，特别是视网膜病变或关节炎，通过给予这些化合物进行治疗。它还涉及包含这些化合物的制药组合物，更具体地用于治疗癌症（如白血病）、眼部疾病和关节炎。
• NOVEL COMPOUNDS AND METHODS OF TREATING CELL PROLIFERATIVE DISEASES, RETINOPATHIES AND ARTHRITIS
  申请人：LEBLOND Bertrand

  公开号：US20090216014A1

  公开（公告）日：2009-08-27

  The present invention relates to compounds and their uses, particularly in the pharmaceutical industry. The invention discloses compounds having anti-proliferative and antiangiogenic activities, as well as methods for treating various diseases associated with abnormal cell proliferation, including cancer, or associated with unregulated angiogenesis including growth and metastasis of solid tumors, ocular diseases and especially retinopathies, or arthritis, by administering said compounds. It further deals with pharmaceutical compositions comprising said compounds, more particularly useful to treat cancers (such as leukemia), ocular diseases and arthritis.

  本发明涉及化合物及其用途，尤其是在制药业中的应用。该发明揭示了具有抗增殖和抗血管生成活性的化合物，以及通过给予该化合物治疗与异常细胞增殖有关的各种疾病的方法，包括癌症，或与不受调节的血管生成有关的疾病，包括实体肿瘤的生长和转移，眼部疾病，尤其是视网膜病变或关节炎。它还涉及包含该化合物的制药组合物，特别是用于治疗癌症（如白血病）、眼部疾病和关节炎。
• Methods of Treating Nervous Disorders
  申请人：Desire Laurent

  公开号：US20090093471A1

  公开（公告）日：2009-04-09

  The invention relates to compositions and methods for treating nervous disorders. More particularly, the invention relates to methods of treating amyloÊd beta peptide-related disorders, particularly Alzheimer's disease, using Rac1 inhibitors. The invention may be used in mammalian subjects, particularly human subjects, at various stages of the disease, including disease onset. The invention also provides methods of producing, identifying, selecting or optimising compounds for use in the treatment of amyloÊd beta peptide-related disorders, based on a determination of the ability of a test compound to inhibit Rac 1.

  本发明涉及治疗神经系统疾病的组合物和方法。更具体地说，本发明涉及使用Rac1抑制剂治疗与淀粉样蛋白β肽相关的疾病，尤其是阿尔茨海默病的方法。本发明可用于哺乳动物受试者，尤其是人类受试者，在包括疾病起始阶段在内的各个疾病阶段。本发明还提供了基于测试化合物抑制Rac1的能力来生产、鉴定、选择或优化用于治疗淀粉样蛋白β肽相关疾病的化合物的方法。
• Compounds and methods of treating cell proliferative diseases, retinopathies and arthritis
  申请人：Exonhit Therapeutics S.A.

  公开号：EP1471063A1

  公开（公告）日：2004-10-27

  The present invention relates to compounds having a general formula (1) and their uses, particularly in the pharmaceutical industry. The invention discloses compounds having antiproliferative and antiangiogenic activities, as well as methods for treating various diseases associated with abnormal cell proliferation, including cancer, or associated with unregulated angiogenesis including growth and metastasis of solid tumors, ocular diseases and especially retinopathies, or arthritis, by administering said compounds. It further deals with pharmaceutical compositions comprising said compounds, more particularly useful to treat cancers, ocular diseases and arthritis.

  本发明涉及具有通式（1）的化合物及其用途，特别是在制药行业中的用途。本发明公开了具有抗增殖和抗血管生成活性的化合物，以及通过施用所述化合物治疗与异常细胞增殖相关的各种疾病（包括癌症）或与未调节的血管生成相关的疾病（包括实体瘤的生长和转移）、眼部疾病（尤其是视网膜病变）或关节炎的方法。本研究还涉及包含上述化合物的药物组合物，尤其适用于治疗癌症、眼部疾病和关节炎。
• COMPOUNDS AND METHODS OF TREATING CELL PROLIFERATIVE DISEASES, RETINOPATHIES AND ARTHRITIS
  申请人：Exonhit Therapeutics S.A.

  公开号：EP1597253A2

  公开（公告）日：2005-11-23