dimethylpentadecan-1-ol | 87383-23-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: dimethylpentadecan-1-ol
• 英文别名: 2-methyl-2-hexadecanol；2-Methylhexadecan-2-OL
• CAS: 87383-23-1
• 化学式: C₁₇H₃₆O
• 分子量: 256.472
• InChiKey: RNARYAUSQQNJOM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.4
• 重原子数：
  18
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  dimethylpentadecan-1-ol 在 盐酸 、 三氯化铁 作用下， 以 二氯甲烷 为溶剂， 反应 36.0h， 生成 2-methyl-2-phenylhexadecane
  参考文献：
  名称：

  Keegstra, Menno A.; Feyter, Steven De; Schryver, Frans C. De, Angewandte Chemie, 1996, vol. 108, # 7, p. 830 - 833

  摘要：

  DOI：
• 作为产物：
  描述：

  溴代十四烷 、 丙酮 在 magnesium 作用下， 生成 dimethylpentadecan-1-ol
  参考文献：
  名称：

  Keegstra, Menno A.; Feyter, Steven De; Schryver, Frans C. De, Angewandte Chemie, 1996, vol. 108, # 7, p. 830 - 833

  摘要：

  DOI：

文献信息

• α-Substituted Malonester Amides:  Tools To Define the Relationship between ACAT Inhibition and Adrenal Toxicity
  作者：Drago R. Sliskovic、Joseph A. Picard、Patrick M. O'Brien、Peggy Liao、W. Howard Roark、Bruce D. Roth、Maureen A. Anderson、Sandra Bak Mueller、Thomas M. A. Bocan、Richard F. Bousley、Katherine L. Hamelehle、Reynold Homan、James F. Reindel、Richard L. Stanfield、Daniel Turluck、Brian R. Krause

  DOI：10.1021/jm970560h

  日期：1998.2.1

  evaluated for their ability to inhibit acyl-CoA:cholesterol O-acyl transferase activity in vitro and to lower plasma total cholesterol levels in a variety of cholesterol-fed animal models. Compounds of this series were also useful in examining the relationship between adrenal toxicity and ACAT inhibition. One compound from this series, 9f, was a potent inhibitor of ACAT in both the microsomal and cellular

  我们制备了一系列的α-取代的马诺酯酰胺，评估了它们在体外抑制酰基辅酶A：胆固醇O-酰基转移酶活性并降低各种胆固醇喂养的动物模型中血浆总胆固醇水平的能力。该系列化合物还可用于检查肾上腺毒性和ACAT抑制之间的关系。在微粒体和细胞测定中，该系列的一种化合物9f是ACAT的有效抑制剂。如通过生物测定和HPLC-UV测定所确定的，其也是生物可利用的。在豚鼠和狗的肾上腺毒性模型中均对该化合物进行了评估，并与四唑酰胺15进行了比较。然而，化合物9f导致肾上腺坏死，而化合物15对肾上腺无作用。这增加了越来越多的证据表明，用ACAT抑制剂观察到的肾上腺毒性可能与机制无关。
• PROCESS FOR PRODUCING ESTER COMPOUND
  申请人：Imazeki Shigeaki

  公开号：US20100324314A1

  公开（公告）日：2010-12-23

  PROBLEM To provide an environmentally-friendly method for producing industrially an ester compound. SOLUTION The present invention is a method for producing an ester compound which comprises subjecting a carboxylic acid and an alcohol to dehydration-condensation reaction using an involatile acid catalyst and then removing the residual acid catalyst by bringing a weak basic substance into contact with the residual acid catalyst.

  问题提供一种生产工业酯化合物的环保方法。 解决方案是一种生产酯化合物的方法，包括将羧酸和醇经过脱水缩合反应，使用一种不挥发的酸催化剂，然后通过将弱碱性物质与残留的酸催化剂接触来去除残留的酸催化剂。
• METHOD FOR PRODUCING 2-HALOGENATED BENZOIC ACIDS
  申请人：SUMITOMO SEIKA CHEMICALS CO., LTD.

  公开号：US20180086687A1

  公开（公告）日：2018-03-29

  The purpose of the present invention is to provide a method for producing 2-halogenated benzoic acids, the method imparting high regioselectivity (high selectivity) and having a shorter reaction time than does the conventional reaction. This method for producing 2-halogenated benzoic acids, in order to achieve the above purpose, is characterized in that benzoic acids and a halogenating agent are reacted in the presence of an alkaline compound, making it possible to highly selectively obtain 2-halogenated benzoic acids.

  本发明的目的是提供一种生产2-卤代苯甲酸的方法，该方法具有高区域选择性（高选择性），且反应时间比传统方法更短。为了实现上述目的，这种生产2-卤代苯甲酸的方法的特点在于在碱性化合物存在下，将苯甲酸和卤代试剂反应，从而能够高度选择性地获得2-卤代苯甲酸。
• Heat-set gels and egg-like vesicles using two component gel system based on chiral calix[4]arenes
  作者：Jin-Lan Zhou、Xian-Jie Chen、Yan-Song Zheng

  DOI：10.1039/b713548c

  日期：——

  Chiral calix[4]arenes bearing long tertiary alkyl groups at the upper rim and S-1-phenylethylamine groups at the lower rim can form heat-set gels and egg-like vesicles enantioselectively with D-2,3-dibenzoyltartaric acid in cyclohexane, which is the first example of heat-set gels resulting from difference in interactions between two component gelators: in addition, the diameter of vesicles decreased with the increase in length of alkyl groups, which could be used to control the size of the vesicles.

  上缘带有长叔烷基、下缘带有S-1-苯乙胺基团的手性杯[4]芳烃可以在环己烷中与D-2,3-二苯甲酰酒石酸对映选择性地形成热定形凝胶和蛋状囊泡，这是由两种组分胶凝剂之间的相互作用差异产生的热定形凝胶的第一个例子：此外，囊泡的直径随着烷基长度的增加而减小，这可用于控制囊泡的大小。
• Hybrid onium salt
  申请人：Ishihara Masami

  公开号：US20050020710A1

  公开（公告）日：2005-01-27

  The present invention relates to a hybrid type onium salt having an iodonium salt and a sulfonium salt in the molecule, useful, for example, as a cationic type photopolymerization initiator and an acid generator for a chemically amplified resist and provides a hybrid type onium salt shown by the general formula [1]: [wherein R 1 to R 3 are each independently a halogen atom, an alkyl group, a haloalkyl group, an aryl group, an alkoxy group, an aryloxy group, an alkylthio group, an arylthio group or an amino group which maybe substituted; Q 1 is a direct-linkage, an oxygen atom, a sulfur atom or a lower alkylene chain; T 1 is an alkylene group or an arylene group, which may have a substituent selected from the group consisting of a halogen atom, an alkyl group, a haloalkyl group, an aryl group, an alkoxy group, an aryloxy group, an alkylthio group, an arylthio group and an amino group which may be substituted; and R 4 is an alkyl group, an alkenyl group, an aryl group or an aralkyl group, which may have a substituent selected from the group consisting of a halogen atom, an alkyl group, a haloalkyl group, an aryl group, an alkoxy group, an aryloxy group, an alkylthio group, an arylthio group and an amino group which may be substituted or a group shown by the general formula [2]: (wherein R 5 to R 7 are each independently a halogen atom, an alkyl group, a haloalkyl group, an aryl group, an alkoxy group, an aryloxy group, an alkylthio group, an arylthio group or an amino group which maybe substituted; Q 2 is a direct-linkage, an oxygen atom, a sulfur atom or a lower alkylene chain; T 2 an alkylene group or an arylene group, which may have a substituent selected from the group consisting of a halogen atom, an alkyl group, a haloalkyl group, an aryl group, an alkoxy group, an aryloxy group, an alkylthio group, an arylthio group and an amino group which may be substituted; A 3 is a counter anion; m is an integer of 0 to 4; and two ns are each independently an integer of 0 to 5); A 1 and A 2 are each independently a counter anion; and m and n are the same as described above], and a polymerization initiator or an acid generator, comprising said onium salt.

  本发明涉及一种杂化型离子盐，其分子中具有碘化离子盐和亚砜盐，例如，作为阳离子型光聚合引发剂和化学放大型抗蚀剂的酸发生剂有用，并提供由通式[1]所示的杂化型离子盐：[其中R1至R3分别独立地是卤素原子、烷基、卤代烷基、芳基、烷氧基、芳氧基、烷硫基、芳硫基或氨基，可被取代；Q1是直链、氧原子、硫原子或较低的烷基链；T1是烷基或芳基，可具有从卤素原子、烷基、卤代烷基、芳基、烷氧基、芳氧基、烷硫基、芳硫基和可被取代的氨基中选择的取代基；R4是烷基、烯丙基、芳基或芳基烷基，可具有从卤素原子、烷基、卤代烷基、芳基、烷氧基、芳氧基、烷硫基、芳硫基和可被取代的氨基中选择的取代基或由通式[2]所示的基：（其中R5至R7分别独立地是卤素原子、烷基、卤代烷基、芳基、烷氧基、芳氧基、烷硫基、芳硫基或氨基，可被取代；Q2是直链、氧原子、硫原子或较低的烷基链；T2是烷基或芳基，可具有从卤素原子、烷基、卤代烷基、芳基、烷氧基、芳氧基、烷硫基、芳硫基和可被取代的氨基中选择的取代基；A3是一个对离子；m是0到4的整数；两个n各自独立地是0到5的整数）；A1和A2各自独立地是一个对离子；m和n与上述描述相同]，以及包含该离子盐的聚合引发剂或酸发生剂。