1-(4-Bromophenyl)-4-(2-chlorophenyl)butane-1,4-dione | 904686-00-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(4-Bromophenyl)-4-(2-chlorophenyl)butane-1,4-dione
• CAS: 904686-00-6
• 化学式: C₁₆H₁₂BrClO₂
• 分子量: 351.627
• InChiKey: ZZQDWGXPTALOBB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-(4-Bromophenyl)-4-(2-chlorophenyl)butane-1,4-dione 、 苯酚 在 palladium diacetate 、 2-(二叔丁基膦)联苯 potassium acetate 作用下， 以 甲苯 为溶剂， 反应 18.0h， 以36%的产率得到1-(2-Chlorophenyl)-4-(4-phenoxyphenyl)butane-1,4-dione
  参考文献：
  名称：

  Amino-pyridines as inhibitors of beta-secretase

  摘要：

  本发明提供了一种化学式I的氨基吡啶化合物。本发明还提供了利用该化合物抑制β-分泌酶（BACE）并治疗β-淀粉样沉积和神经原纤维缠结的方法。

  公开号：

  US20060173049A1

文献信息

• Amino-pyridines As Inhibitors Of Beta-secretase
  申请人：Malamas Michael Sotirios

  公开号：US20100204245A1

  公开（公告）日：2010-08-12

  The present invention provides an amino-pyridine compound of formula I The present invention also provides methods for the use thereof to inhibit β-secretase (BACE) and treat β-amyloid deposits and neurofibrillary tangles.

  本发明提供了一种式为I的氨基吡啶化合物。本发明还提供了使用该化合物的方法，以抑制β-分泌酶（BACE）并治疗β-淀粉样沉积和神经原纤维缠结。
• Gamma-diketones for treatment and prevention of aging skin and wrinkles
  申请人：Samumed, LLC

  公开号：US10434052B2

  公开（公告）日：2019-10-08

  The present disclosure relates to compounds having the following structure: or a dermatologically acceptable salt thereof, and cosmetic or dermopharmaceutical compositions comprising the same, and methods for using the compounds or compositions for treating, protecting, and/or improving the condition and/or aesthetic appearance of skin, for example, treating, preventing, ameliorating, reducing and/or eliminating fine lines and/or wrinkles of skin, or improving the appearance of fine lines and/or or wrinkles of skin comprising application of the compounds or compositions disclosed.

  本公开涉及具有以下结构的化合物： 或其皮肤学上可接受的盐，以及包含这些化合物的化妆品或皮肤药物组合物，以及使用这些化合物或组合物治疗、保护和/或改善皮肤状况和/或美学外观的方法，例如，治疗、预防、改善、减少和/或消除皮肤细纹和/或皱纹，或改善皮肤细纹和/或或皱纹的外观，包括应用所公开的化合物或组合物。
• GAMMA-DIKETONES FOR TREATMENT AND PREVENTION OF AGING SKIN AND WRINKLES
  申请人：Samumed, LLC

  公开号：US20160206540A1

  公开（公告）日：2016-07-21

  The present disclosure relates to compounds, cosmetic or dermopharmaceutical compositions comprising the same, and methods for using the compounds or compositions for treating, protecting, and/or improving the condition and/or aesthetic appearance of skin, for example, treating, preventing, ameliorating, reducing and/or eliminating fine lines and/or wrinkles of skin, or improving the appearance of fine lines and/or or wrinkles of skin comprising application of the compounds or compositions disclosed.
• GAMMA-DIKETONES AS WNT/BETA -CATENIN SIGNALING PATHWAY ACTIVATORS
  申请人：Samumed, LLC

  公开号：US20170260176A1

  公开（公告）日：2017-09-14

  The present disclosure provides γ-diketones or analogs thereof, that activate Wnt/β-catenin signaling and thus treat or prevent diseases related to signal transduction, such as osteoporosis and osteoarthropathy; osteogenesis imperfecta, bone defects, bone fractures, periodontal disease, otosclerosis, wound healing, craniofacial defects, oncolytic bone disease, traumatic brain injuries or spine injuries, brain atrophy/neurological disorders related to the differentiation and development of the central nervous system, including Parkinson's disease, strokes, ischemic cerebral disease, epilepsy, Alzheimer's disease, depression, bipolar disorder, schizophrenia; otic disorders like cochlear hair cell loss; eye diseases such as age related macular degeneration, diabetic macular edema or retinitis pigmentosa and diseases related to differentiation and growth of stem cell, such as hair loss, hematopoiesis related diseases and tissue regeneration related diseases.
• US7732457B2
  申请人：——

  公开号：US7732457B2

  公开（公告）日：2010-06-08