d-galactosamine | 686298-83-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: d-galactosamine
• 英文别名: glucosamine；d-glucosamine；galactosamine；2-Amino-2-Deoxy-Hexose；3-amino-6-(hydroxymethyl)oxane-2,4,5-triol
• CAS: 686298-83-9
• 化学式: C₆H₁₃NO₅
• 分子量: 179.173
• InChiKey: MSWZFWKMSRAUBD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.8
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  116
• 氢给体数：
  5
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (2S)-3-(4-(5-(1,2-dithiolan-3-yl)pentanamido)phenyl)-2-(4-chlorobenzamido)propanoic acid 、 d-galactosamine 在 N-羟基丁二酰亚胺 、 三乙胺 、 N,N'-二环己基碳二亚胺 作用下， 以 四氢呋喃 为溶剂， 生成
  参考文献：
  名称：

  Enhancing Cell Recognition by Scrutinizing Cell Surfaces with a Nanoparticle Array

  摘要：

  We report a dual-ligand nanoparticle array approach for discerning cells that have different surface receptor profiles surrounding a common primary receptor expressed at high or low levels. The achieved differentiation provides nanoparticles the ability for potential applications in treatment of patients at a personalized medicine level for drug delivery and radiation therapy with a much better safety profile.

  DOI：

  10.1021/ja108527y

文献信息

• Method of producing conjugate vaccines
  申请人：Finn Nicholas

  公开号：US20080213297A1

  公开（公告）日：2008-09-04

  The present invention relates to a method of production of a hydrazide modified sugar comprising a step of reacting a sugar with a hydrazide in a reaction solvent at a pH of between 3 and 5.5, wherein the solvent comprises an aqueous based solvent and an optional polar organic co-solvent. A further aspect of the invention relates to a method of production of a polysaccharide epitope carrier protein conjugate comprising the steps of: (a) reacting a polysaccharide epitope with a hydrazide to form a hydrazide modified polysaccharide epitope; (b) reacting the hydrazide modified polysaccharide epitope with a linker that has been pre-coupled to a carrier protein. Another aspect of the invention relates to a method of production of a sugar-dihydrazide-aldehyde adduct comprising the steps of: (a) producing a hydrazide modified sugar using a method according to the invention, wherein the hydrazide modified sugar includes a further unreacted hydrazide moiety; and (b) reacting the further hydrazide moiety with the aldehyde functionality of a linker group.

  本发明涉及一种生产含有肼改性糖的方法，包括在反应溶剂中将糖与肼在pH值在3至5.5之间反应的步骤，其中溶剂包括水基溶剂和可选的极性有机共溶剂。该发明的另一个方面涉及一种生产多糖表位载体蛋白共轭物的方法，包括以下步骤：(a)将多糖表位与肼反应，形成肼改性多糖表位；(b)将肼改性多糖表位与预先偶联到载体蛋白上的连接剂反应。该发明的另一个方面涉及一种生产糖-二肼-醛加合物的方法，包括以下步骤：(a)使用根据本发明的方法生产肼改性糖，其中肼改性糖包括进一步未反应的肼基团；(b)将进一步的肼基团与连接剂基团的醛功能基团反应。
• [EN] TARGETED NUCLEIC ACID CONJUGATE COMPOSITIONS<br/>[FR] COMPOSITIONS DE CONJUGUÉS D'ACIDES NUCLÉIQUES CIBLÉS
  申请人：PROTIVA BIOTHERAPEUTICS INC

  公开号：WO2017177326A1

  公开（公告）日：2017-10-19

  The invention provides conjugates that comprise a targeting moiety, a nucleic acid, and optional linking groups as well as synthetic intermediates and synthetic methods useful for preparing the conjugates. The conjugates are useful to target therapeutic nucleic acids to the liver and to treat liver diseases including hepatitis (e.g. hepatitis B and hepatitis D).

  这项发明提供了包括靶向基团、核酸和可选连接基团的共轭物，以及用于制备这些共轭物的合成中间体和合成方法。这些共轭物可用于将治疗性核酸靶向肝脏，并用于治疗包括肝炎（如乙型肝炎和丙型肝炎）在内的肝脏疾病。
• SACCHARIDE STRUCTURES AND METHODS OF MAKING AND USING SUCH STRUCTURES
  申请人：Roy Sucharita

  公开号：US20110201801A1

  公开（公告）日：2011-08-18

  Described are oligosaccharides having a protecting group at two, a plurality, a majority of, or each position in the oligosaccharide which is amenable to derivatization. Collections, libraries and methods of making and using such oligosaccharides are also described.

  描述了具有保护基团的寡糖，该保护基团位于适于衍生的寡糖的两个、多个、大多数或每个位置。还描述了此类寡糖的集合、库以及制造和使用方法。
• [EN] GLYCOSYLATED ANTITUMOR ETHER LIPIDS AS NOVEL CANCER STEM CELL CYTOTOXIC AGENTS<br/>[FR] ÉTHER-LIPIDES ANTICANCÉREUX GLYCOSYLÉS EN TANT QUE NOUVEAUX AGENTS CYTOTOXIQUES DE CELLULES SOUCHES CANCÉREUSES
  申请人：UNIV MANITOBA

  公开号：WO2013116949A1

  公开（公告）日：2013-08-15

  Glycosylated antitumor ether lipids (GAELs) are effective cytotoxic agents against cancer stem cells. Furthermore, combining GAELs which kill cells by a caspase-independent pathway with agents that kill cells by apoptosis will lead to elimination of the differentiated tumor cells and the undifferentiated cancer stem cells leading to an elimination of the tumor and preventing recurrence.

  糖基化抗肿瘤醚脂质（GAELs）是有效的细胞毒性剂，可针对癌干细胞。此外，将通过一种与半胱氨酸蛋白酶无关的途径杀死细胞的GAELs与通过凋亡杀死细胞的药物结合，将导致消除分化的肿瘤细胞和未分化的癌干细胞，从而消除肿瘤并预防复发。
• BIFUNCTIONAL COMPOUND WITH MONOSACCHARIDE AND N2S2 LIGAND, AND PREPARATION AND USE THEREOF
  申请人：LIU SHOW-WEN

  公开号：US20120009669A1

  公开（公告）日：2012-01-12

  A bifunctional compound with a monosaccharide and a N 2 S 2 ligand, and more particularly, a bifunctional compound with a N 2 S 2 ligand and aminohexylacetyl galactosamine (ah-GalNAc 4 ) is provided. A method for preparing the bifunctional compound with a monosaccharide and a N 2 S 2 ligand is also provided, including activating a carboxyl group in an organic ligand, reacting the activated carboxyl group with a galactopyranoside through amidation, and then hydrolyzing. The bifunctional compound of the present invention is widely useful in nuclear medicine for preparation of liver imaging agents for assisting in correct diagnosis of diseases.

  提供了一种具有单糖和N2S2配体的双功能化合物，更具体地说，提供了一种具有N2S2配体和氨基己酰半乳糖胺（ah-GalNAc4）的双功能化合物。还提供了一种制备具有单糖和N2S2配体的双功能化合物的方法，包括激活有机配体中的羧基，通过酰胺化将激活的羧基与半乳糖苷反应，然后水解。本发明的双功能化合物在核医学中广泛用于制备肝脏成像剂，以帮助正确诊断疾病。