1-(2-hydroxy-4,6-diisopropylsilyloxyphenyl)ethanone | 1198596-15-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(2-hydroxy-4,6-diisopropylsilyloxyphenyl)ethanone
• CAS: 1198596-15-4
• 化学式: C₂₆H₄₈O₄Si₂
• 分子量: 480.836
• InChiKey: ZSTKQGVSOJVKFH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.7
• 重原子数：
  32.0
• 可旋转键数：
  11.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  55.76
• 氢给体数：
  1.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  4-苄氧基-3-甲氧基苯甲醛 、 1-(2-hydroxy-4,6-diisopropylsilyloxyphenyl)ethanone 在 sodium hydride 作用下， 以 四氢呋喃 、 mineral oil 为溶剂， 反应 2.5h， 以82%的产率得到
  参考文献：
  名称：

  Stable solid-supported leucoanthocyanidin variants for flavanoid biosynthesis elucidation

  摘要：

  Remarkable progress toward the complete elucidation of the biosynthesis of flavanoids has been accomplished during the last decade, but the final steps presumably involving the transformation of leucoanthocyanidins, which are highly unstable when free in aqueous solution into both anthocyanidins and proanthocyanidins still remain to be fully understood. Herein is described the synthesis of stabilized solid-supported leucoanthocyanidin variants that should serve as valuable tools for in vitro studies aimed at investigating the metabolism of these seemingly fleeting common precursors of two main classes of flavanoids. (C) 2009 Elsevier Ltd All lights reserved

  DOI：

  10.1016/j.tetlet.2009.09.045
• 作为产物：
  描述：

  2,4,6-三羟基苯乙酮一水合物 、 三异丙基硅基三氟甲磺酸酯 在 三乙胺 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 1.0h， 以93%的产率得到1-(2-hydroxy-4,6-diisopropylsilyloxyphenyl)ethanone
  参考文献：
  名称：

  Stable solid-supported leucoanthocyanidin variants for flavanoid biosynthesis elucidation

  摘要：

  Remarkable progress toward the complete elucidation of the biosynthesis of flavanoids has been accomplished during the last decade, but the final steps presumably involving the transformation of leucoanthocyanidins, which are highly unstable when free in aqueous solution into both anthocyanidins and proanthocyanidins still remain to be fully understood. Herein is described the synthesis of stabilized solid-supported leucoanthocyanidin variants that should serve as valuable tools for in vitro studies aimed at investigating the metabolism of these seemingly fleeting common precursors of two main classes of flavanoids. (C) 2009 Elsevier Ltd All lights reserved

  DOI：

  10.1016/j.tetlet.2009.09.045