9-(2-deoxy-β-D-ribo-pentofuranosyl)-8-(3,4-methylenedioxyphenylthio)adenine | 1243536-36-8

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: 9-(2-deoxy-β-D-ribo-pentofuranosyl)-8-(3,4-methylenedioxyphenylthio)adenine
• CAS: 1243536-36-8
• 化学式: C₁₇H₁₇N₅O₅S
• 分子量: 403.418
• InChiKey: AMXFADUPCFKDDH-ZWKOPEQDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.93
• 重原子数：
  28.0
• 可旋转键数：
  4.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  137.77
• 氢给体数：
  3.0
• 氢受体数：
  11.0

反应信息

• 作为反应物：
  描述：

  9-(2-deoxy-β-D-ribo-pentofuranosyl)-8-(3,4-methylenedioxyphenylthio)adenine 在 N-溴代丁二酰亚胺(NBS) 作用下， 以 乙腈 为溶剂， 反应 3.0h， 以50%的产率得到8-(6-bromo-3,4-methylenedioxyphenylthio)-9-(2-deoxy-β-D-ribo-pentofuranosyl)adenine
  参考文献：
  名称：

  Efficient synthesis of Hsp90 inhibitor dimers as potential antitumor agents

  摘要：

  The PU-H58-dimers 13a-15b were efficiently synthesized and their biological properties were evaluated. The copper-catalyzed alkyne azide coupling was effective in simultaneously linking three components via a triazole formation to afford the target dimers. These synthesized dimers exhibited binding affinity to the N-terminal domain of Hsp90, cytotoxicity, and client degradation activity although these activities were comparative or weak comparable with that of the parent compound. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2010.05.075
• 作为产物：
  描述：

  3,4-亚甲二氧基苯硫酚 、 8-溴-2'-脱氧腺苷 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 2.0h， 以14 g的产率得到9-(2-deoxy-β-D-ribo-pentofuranosyl)-8-(3,4-methylenedioxyphenylthio)adenine
  参考文献：
  名称：

  Efficient synthesis of Hsp90 inhibitor dimers as potential antitumor agents

  摘要：

  The PU-H58-dimers 13a-15b were efficiently synthesized and their biological properties were evaluated. The copper-catalyzed alkyne azide coupling was effective in simultaneously linking three components via a triazole formation to afford the target dimers. These synthesized dimers exhibited binding affinity to the N-terminal domain of Hsp90, cytotoxicity, and client degradation activity although these activities were comparative or weak comparable with that of the parent compound. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2010.05.075