5-[5-(tert-Butyl-diphenyl-silanyloxy)-pentyl]-5-methoxy-5H-furan-2-one | 738604-51-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5-[5-(tert-Butyl-diphenyl-silanyloxy)-pentyl]-5-methoxy-5H-furan-2-one
• 英文别名: 5-[5-[Tert-butyl(diphenyl)silyl]oxypentyl]-5-methoxyfuran-2-one
• CAS: 738604-51-8
• 化学式: C₂₆H₃₄O₄Si
• 分子量: 438.639
• InChiKey: CWPPLKLOHLHBCQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.58
• 重原子数：
  31
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  5-[5-(tert-Butyl-diphenyl-silanyloxy)-pentyl]-5-methoxy-5H-furan-2-one 在 四丁基氟化铵 作用下， 以 四氢呋喃 为溶剂， 以71%的产率得到2(5H)-Furanone, 5-(5-hydroxypentyl)-5-methoxy-
  参考文献：
  名称：

  The furan approach to oxacycles: synthesis of medium-size 2,3-disubstituted oxacycles

  摘要：

  We describe an efficient new approach for the synthesis of medium-size oxacycles that is based on the oxidation of a furan ring with singlet oxygen followed by an intramolecular Michael addition. This present study enlarges the scope of the furan approach strategy for the synthesis of oxepanes. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2004.05.035
• 作为产物：
  描述：

  tert-butyl-(5-iodo-pentyloxy)-diphenyl-silane 在 2,2'-联吡啶 、 正丁基锂 、 oxygen 、 rose bengal 作用下， 以 四氢呋喃 为溶剂， 生成 5-[5-(tert-Butyl-diphenyl-silanyloxy)-pentyl]-5-methoxy-5H-furan-2-one
  参考文献：
  名称：

  The furan approach to oxacycles: synthesis of medium-size 2,3-disubstituted oxacycles

  摘要：

  We describe an efficient new approach for the synthesis of medium-size oxacycles that is based on the oxidation of a furan ring with singlet oxygen followed by an intramolecular Michael addition. This present study enlarges the scope of the furan approach strategy for the synthesis of oxepanes. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2004.05.035

文献信息

• The furan approach to oxacycles: synthesis of medium-size 2,3-disubstituted oxacycles
  作者：Manuel Pérez、Pilar Canoa、Generosa Gómez、Carmen Terán、Yagamare Fall

  DOI：10.1016/j.tetlet.2004.05.035

  日期：2004.6

  We describe an efficient new approach for the synthesis of medium-size oxacycles that is based on the oxidation of a furan ring with singlet oxygen followed by an intramolecular Michael addition. This present study enlarges the scope of the furan approach strategy for the synthesis of oxepanes. (C) 2004 Elsevier Ltd. All rights reserved.