5-(5-bromo-3-chlorothiophen-2-yl)-3-(2-chloro-6-fluorophenyl)-1-methyl-1H-[1,2,4]triazole | 952049-42-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-(5-bromo-3-chlorothiophen-2-yl)-3-(2-chloro-6-fluorophenyl)-1-methyl-1H-[1,2,4]triazole
• 英文别名: 5-(5-Bromo-3-chlorothiophen-2-yl)-3-(2-chloro-6-fluorophenyl)-1-methyl-1,2,4-triazole
• CAS: 952049-42-2
• 化学式: C₁₃H₇BrCl₂FN₃S
• 分子量: 407.093
• InChiKey: CMYXMHWCJNCGGR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  59
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  5-(5-bromo-3-chlorothiophen-2-yl)-3-(2-chloro-6-fluorophenyl)-1-methyl-1H-[1,2,4]triazole 、 4-三氟甲氧基苯硼酸 在 bis-triphenylphosphine-palladium(II) chloride sodium carbonate 、 三(邻甲基苯基)磷 作用下， 以 水 、 乙腈 为溶剂， 反应 20.0h， 以62%的产率得到3-(2-chloro-6-fluorophenyl)-5-[3-chloro-5-(4-trifluoromethoxyphenyl)thiophen-2-yl]-1-methyl-1H-[1,2,4]triazole
  参考文献：
  名称：

  Structure−Activity Relationship Development of Dihaloaryl Triazole Compounds as Insecticides and Acaricides. 1. Phenyl Thiophen-2-yl Triazoles

  摘要：

  An extended lipophilic system that incorporated some key elements of first-gene ration 2,6-dihaloaryl actives, such as 1, demonstrated desirable efficacy against chewing insects as well as sap-feeding insects. These four-ring systems, based on 2, were accessed primarily via Suzuki couplings of halothiophene derivatives with appropriately substituted boronic acids. In particular, phenylthiophene systems that incorporated haloxyether groups, such as those in 3, 4, and 5, had the broadest spectrum of activity across chewing and sap-feeding insect pests. Expansion of this structu re- activity relationship to include compounds with differing substitution patterns on the thiophene-C-ring and aryl-D-rings was undertaken. The synthesis and insecticidal activity of 3-aryl-5-(thiophen-2-yl)-l -methyl1 H-[1,2,4]triazoles will be described.

  DOI：

  10.1021/jf071498s
• 作为产物：
  描述：

  3-(2-chloro-6-fluorophenyl)-5-(3-chlorothiophen-2-yl)-1-methyl-1H-[1,2,4]triazole 在 溴 、 sodium acetate 、 溶剂黄146 作用下， 反应 37.0h， 以51%的产率得到5-(5-bromo-3-chlorothiophen-2-yl)-3-(2-chloro-6-fluorophenyl)-1-methyl-1H-[1,2,4]triazole
  参考文献：
  名称：

  Structure−Activity Relationship Development of Dihaloaryl Triazole Compounds as Insecticides and Acaricides. 1. Phenyl Thiophen-2-yl Triazoles

  摘要：

  An extended lipophilic system that incorporated some key elements of first-gene ration 2,6-dihaloaryl actives, such as 1, demonstrated desirable efficacy against chewing insects as well as sap-feeding insects. These four-ring systems, based on 2, were accessed primarily via Suzuki couplings of halothiophene derivatives with appropriately substituted boronic acids. In particular, phenylthiophene systems that incorporated haloxyether groups, such as those in 3, 4, and 5, had the broadest spectrum of activity across chewing and sap-feeding insect pests. Expansion of this structu re- activity relationship to include compounds with differing substitution patterns on the thiophene-C-ring and aryl-D-rings was undertaken. The synthesis and insecticidal activity of 3-aryl-5-(thiophen-2-yl)-l -methyl1 H-[1,2,4]triazoles will be described.

  DOI：

  10.1021/jf071498s

文献信息

• Structure−Activity Relationship Development of Dihaloaryl Triazole Compounds as Insecticides and Acaricides. 1. Phenyl Thiophen-2-yl Triazoles
  作者：Denise P. Cudworth、Vidyadhar B. Hegde、Maurice C. H. Yap、Katherine A. Guenthenspberger、Christopher T. Hamilton、James T. Pechacek、Peter L. Johnson、Scott J. Bis、F. Eugene Tisdell、James E. Dripps、Timothy J. Bruce、Leonard P. Dintenfass、James M. Gifford、Laura L. Karr、Margaret K. Kempe、D'Lee C. McCormick、Joseph R. Schoonover

  DOI：10.1021/jf071498s

  日期：2007.9.1

  An extended lipophilic system that incorporated some key elements of first-gene ration 2,6-dihaloaryl actives, such as 1, demonstrated desirable efficacy against chewing insects as well as sap-feeding insects. These four-ring systems, based on 2, were accessed primarily via Suzuki couplings of halothiophene derivatives with appropriately substituted boronic acids. In particular, phenylthiophene systems that incorporated haloxyether groups, such as those in 3, 4, and 5, had the broadest spectrum of activity across chewing and sap-feeding insect pests. Expansion of this structu re- activity relationship to include compounds with differing substitution patterns on the thiophene-C-ring and aryl-D-rings was undertaken. The synthesis and insecticidal activity of 3-aryl-5-(thiophen-2-yl)-l -methyl1 H-[1,2,4]triazoles will be described.