trans-1-[4-(benzoylamino)phenyl]-3-phenyl-1-propen-3-one | 1024592-14-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: trans-1-[4-(benzoylamino)phenyl]-3-phenyl-1-propen-3-one
• 英文别名: 1-phenyl-3-(p-benzamidophenyl)-2-propen-1-one；N-{4-[(1E)-3-oxo-3-phenylprop-1-en-1-yl]phenyl}benzamide；N-[4-[(E)-3-oxo-3-phenylprop-1-enyl]phenyl]benzamide
• CAS: 1024592-14-0
• 化学式: C₂₂H₁₇NO₂
• 分子量: 327.382
• InChiKey: ZSCOPPVOKVWXIL-DTQAZKPQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  46.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  trans-1-[4-(benzoylamino)phenyl]-3-phenyl-1-propen-3-one 在 air 作用下， 以 N,N-二甲基乙酰胺 为溶剂， 生成 cis-1-[4-(benzoylamino)phenyl]-3-phenyl-1-propen-3-one
  参考文献：
  名称：

  摘要：

  A relationship is found between spectral-luminescent and photochemical properties for mono- and disubstituted chalcone derivatives (RCO)-C-1-CH=CHR2 [R-1, R-2 = Ph, 4-FC6H4, 4-BrC6H4, 2-furyl, 2-thienyl, 4-(PhCONH)C6H4, 4-NH2C6H4, 4-Me2NC6H4].

  DOI：

  10.1023/a:1013237415295
• 作为产物：
  描述：

  N-(4-甲酰基苯基)苯甲酰胺 、 苯乙酮 生成 trans-1-[4-(benzoylamino)phenyl]-3-phenyl-1-propen-3-one
  参考文献：
  名称：

  摘要：

  A relationship is found between spectral-luminescent and photochemical properties for mono- and disubstituted chalcone derivatives (RCO)-C-1-CH=CHR2 [R-1, R-2 = Ph, 4-FC6H4, 4-BrC6H4, 2-furyl, 2-thienyl, 4-(PhCONH)C6H4, 4-NH2C6H4, 4-Me2NC6H4].

  DOI：

  10.1023/a:1013237415295

文献信息

• A new Heck reaction modification using ketone Mannich bases as enone precursors: Parallel synthesis of anti-leishmanial chalcones
  作者：Christina Reichwald、Orly Shimony、Nina Sacerdoti-Sierra、Charles L. Jaffe、Conrad Kunick

  DOI：10.1016/j.bmcl.2008.01.112

  日期：2008.3

  A new Heck-type reaction for the synthesis of chalcones has been established using Mannich bases as enone precursors. The novel reaction proceeds rapidly in air atmosphere under ligandless conditions and can be adapted for library synthesis in a parallel reactor station. Screening of the synthesized chalcones revealed N-4-[(1E)-3-oxo-3-(3-pyridinyl)-1-propenyl]phenyl} benzamide (3f) to be a potent anti-leishmanial agent. (C) 2008 Elsevier Ltd. All rights reserved.
• ——
  作者：N. I. Rtishchev、G. I. Nosova、N. A. Solovskaya、V. A. Luk'yashina、E. F. Galaktionova、V. V. Kudryavtsev

  DOI：10.1023/a:1013237415295

  日期：——

  A relationship is found between spectral-luminescent and photochemical properties for mono- and disubstituted chalcone derivatives (RCO)-C-1-CH=CHR2 [R-1, R-2 = Ph, 4-FC6H4, 4-BrC6H4, 2-furyl, 2-thienyl, 4-(PhCONH)C6H4, 4-NH2C6H4, 4-Me2NC6H4].