2-(1-hydroxy-cyclohexyl)-but-3-enoic acid methyl ester | 41955-34-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(1-hydroxy-cyclohexyl)-but-3-enoic acid methyl ester
• 英文别名: 2-(1-Hydroxy-cyclohexyl)-but-3-ensaeure-methylester；Methyl 2-(1-hydroxycyclohexyl)-3-butenoate；methyl 2-(1-hydroxycyclohexyl)but-3-enoate
• CAS: 41955-34-4；95728-87-3；95728-89-5
• 化学式: C₁₁H₁₈O₃
• 分子量: 198.262
• InChiKey: IKJUTYHTEZKTSV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-(1-hydroxycyclohexyl)but-3-enoic acid 生成 2-(1-hydroxy-cyclohexyl)-but-3-enoic acid methyl ester
  参考文献：
  名称：

  CASINOS J.; MESTRES R., J. CHEM. SOC. PERKIN TRANS. PART 1, 1978, NO 12, 1651-1655

  摘要：

  DOI：

文献信息

• Reformatsky Type Reaction with New Aluminium Reagents Containing Al–Sn or Al–Pb Linkage
  作者：Seijiro Matsubara、Noriyuki Tsuboniwa、Yoshitomi Morizawa、Koichiro Oshima、Hitosi Nozaki

  DOI：10.1246/bcsj.57.3242

  日期：1984.11

  the reagent prepared from n-Bu3SnLi and Et2AlCl or from SnCl2 and Et2AlCl affords enolates which react with ketone or aldehyde to give β-hydroxy carbonyl compounds in good to excellent yields. The reactions proceed similarly with the reagents which are generated from R3PbLi (R=Ph, n-Bu) and Et2AlCl. Catalysis by the added Pd(PPh3)4 complex promotes the reduction effectively and improves the yields of

  用由 n-Bu3SnLi 和 Et2AlCl 或由 SnCl2 和 Et2AlCl 制备的试剂处理 α-溴羰基化合物，得到烯醇化物，该烯醇化物与酮或醛反应得到 β-羟基羰基化合物，收率良好至极好。反应与由 R3PbLi (R=Ph, n-Bu) 和 Et2AlCl 生成的试剂进行类似。添加的 Pd(PPh3)4 复合物的催化作用有效地促进了还原并提高了所需加合物的产率。公开了区域选择性和立体选择性。
• Reformatsky type reaction by means of Bu3SnA1et2 or Bu3Pba1et2
  作者：Noriyuki Tsuboniwa、Seijiro Matsubara、Yoshitomi Morizawa、Koichiro Oshima、Hitosi Nozaki

  DOI：10.1016/s0040-4039(01)81233-8

  日期：1984.1

  Treatment of α-halo carbonyl compounds with title Sn-Al or Pb-Al reagents provides enolates which react with aldehydes or ketones to give β-hydroxy carbonyl compounds effectively.

  用标题Sn-Al或Pb-Al试剂处理α-卤代羰基化合物可提供烯醇盐，该醛酸酯与醛或酮反应可有效生成β-羟基羰基化合物。
• The Chromium Reformatsky Reaction: Acces to Adjacent Quarternary Centers
  作者：Ludger Wessjohann、Harry Wild

  DOI：10.1055/s-1997-1219

  日期：1997.5

  α-Bromo ketones, -esters and -nitriles react with chromium dichloride and ketones in a Barbier-type reaction to yield the kinetic crossed aldol products with one or two new quarternary centers. The reaction does not require special activation of the reagent, proceeds at room temperature and is suitable for microscale preparations. Crotonates react highly regioselective to yield α-products. The influence of solvents is discussed.

  δ-溴酮、-酯和-硝基化合物与二氯化铬和酮发生巴比耶型反应，生成具有一个或两个新的四元中心的动力学交叉醛醇产物。该反应不需要对试剂进行特殊活化，在室温下进行，适合微量制备。巴豆酸盐反应具有高度的区域选择性，可生成 δ 产物。讨论了溶剂的影响。
• Bortolussi, Michel; Seyden-Penne, Jacqueline, Synthetic Communications, 1989, vol. 19, # 13-14, p. 2355 - 2362
  作者：Bortolussi, Michel、Seyden-Penne, Jacqueline

  DOI：——

  日期：——
• Environmental influences on plant species composition in ground-water seeps in the Catskill Mountains of New York
  作者：Brian R. Hall、Dudley J. Raynal、Donald J. Leopold

  DOI：10.1672/0277-5212(2001)021[0125:eiopsc]2.0.co;2

  日期：2001.3

  Ground-water seeps in the Catskill Mountains are important water sources for streams and often have different chemistry than nearby surface water. Many studies have shown correlations between water chemistry and plant species composition in wetlands, but there are no such studies in the Catskill Mountain ground-water seeps. The objective of this study was to identify the chemical and physical environmental variables that most strongly influence plant species composition in seeps. Environmental variables and plant species abundance were measured at 33 seeps. TWo-way INdicator SPecies ANalysis with analysis of variance and Canonical Correspondence Analysis showed that plant species composition is determined primarily by water depth and alkalinity/acidity complex gradients. Growing season changes in water chemistry were not shown to influence the plant community.