1,4-Dicinnamoyl-benzol | 908-11-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 1,4-Dicinnamoyl-benzol
• 英文别名: 1,4-Dicinnamoylbenzene；3-phenyl-1-[4-(3-phenylprop-2-enoyl)phenyl]prop-2-en-1-one
• CAS: 908-11-2
• 化学式: C₂₄H₁₈O₂
• 分子量: 338.406
• InChiKey: YDJKHVQLADEYIK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1,4-Dicinnamoyl-benzol 在 sulfur 作用下， 以 溶剂黄146 为溶剂， 反应 7.0h， 生成 1,4-Bis-<1,5-diphenyl-pyrazolyl-(3)>-benzol
  参考文献：
  名称：

  Synthesis and absorption-fluorescence properties of

  摘要：

  DOI：

  10.1007/bf00475396
• 作为产物：
  描述：

  对苯二腈 在 sodium hydroxide 、 乙醚 作用下， 生成 1,4-Dicinnamoyl-benzol
  参考文献：
  名称：

  Pfeiffer; Kollbach; Haack, Justus Liebigs Annalen der Chemie, 1928, vol. 460, p. 148

  摘要：

  DOI：

文献信息

• Novel Synthesis of bis Acetylated Hybrid Pyrazoles as Potent Anticandidiasis Agents
  作者：V. Kanagarajan、M. R. Ezhilarasi、M. Gopalakrishnan

  DOI：10.5012/jkcs.2011.55.2.256

  日期：2011.4.20

  Bis acetylated hybrid pyrazoles 을 합성하여 이들 화합물에 대해 녹는점, 원소분석, MS, FT-IR, one-dimensional $^1H,-$ 및 $^13}C$-NMR로 분석하였다. 합성한 화합물들에 대해 in vitro 항균활성을 Candida sp. namely Candida albicans, Candida glabrata, Candida parapsilosis, Candida dubliniensis 및 Candida tropicali 균에 대해 수행하였다. Pyrazoles의 페닐고리에 작용기($-CH_3$, $-OCH_3$, -F, -Cl, 및 Br)가 있는 화합물은 Candida species에 대해서 강한 활성을 나타내었다. A new series of bis acetylated hybrid pyrazoles were synthesized and characterized by their melting point, elemental analysis, MS, FT-IR, one-dimensional $^1H$, and $^13}C$ NMR spectroscopic data. All the synthesized compounds were tested for their in vitro antifungal activities against Candida sp. namely Candida albicans, Candida glabrata, Candida parapsilosis, Candida dubliniensis and Candida tropicalis. A close inspection of the in vitro anticandidal activity profile in differently electron donating ($CH_3$ and $OCH_3$) and electron withdrawing (-F, -Cl, and Br) functional group substituted phenyl rings of novel hybrid pyrazoles exerted strong anticandidal activity against all the tested Candida species.

  >-NMR。 合成的新系列双乙酰基杂化吡唑通过熔点、元素分析、质谱、FT-IR、一维$^1H$和$^13}C$-NMR进行了表征。
• Design and synthesis of heterocyclic Compounds from 1,4-diacetylbenzene with Expected Antimicrobial Activity
  作者：Amira A. Ghoneim、Rehab M. Elbargisy、Afaf Manoer

  DOI：10.21608/ejchem.2020.21641.2289

  日期：2020.2.18

  In this present work, synthesized a novel derivatives of bis-chalcones via condensation of 1,4-diacetylbenzene with different aldehydes in basic media. The reaction of chalcone derivatives 3a,b with thioglycolic acid gave compounds 4a,b. That was reacted with ethyl cyanoacetate in presence of ammonium acetate to give the corresponding cyanopyridine derivatives 5a,b. Furthermore, bis-chalcone 3a,b was cyclization to pyrazole analogs by using 2,4-dinitrophenylhydrazine to give compounds 7a,b in good yields. All products were characterized by IR spectrum, 1HNMR, 13CNMR, and elemental analysis. The new compounds have been screened as anti-bacterial activity

  本研究通过 1,4-二乙酰苯与不同醛类在碱性介质中的缩合反应，合成了一种新型的双查尔酮衍生物。查尔酮衍生物 3a,b 与硫代乙醇酸反应生成了化合物 4a,b。该化合物与氰乙酸乙酯在乙酸铵存在下反应，得到相应的氰基吡啶衍生物 5a,b。此外，用 2,4-二硝基苯肼将双查尔酮 3a,b 环化成吡唑类似物，得到化合物 7a,b，收率很高。所有产物都通过红外光谱、1HNMR、13CNMR 和元素分析进行了表征。对新化合物进行了抗菌活性筛选
• Kurfuerst, Antonin; Lhotak, Pavel; Petru, Miroslav, Collection of Czechoslovak Chemical Communications, 1989, vol. 54, # 2, p. 462 - 472
  作者：Kurfuerst, Antonin、Lhotak, Pavel、Petru, Miroslav、Kuthan, Josef

  DOI：——

  日期：——
• Devi; Ashok; Rao, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1990, vol. 29, # 9, p. 898 - 900
  作者：Devi、Ashok、Rao

  DOI：——

  日期：——
• Pfeiffer; Kollbach; Haack, Justus Liebigs Annalen der Chemie, 1928, vol. 460, p. 148
  作者：Pfeiffer、Kollbach、Haack

  DOI：——

  日期：——