(4-甲基-噻唑-5-基)-乙酸酰胺 | 136384-13-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 中文名称: (4-甲基-噻唑-5-基)-乙酸酰胺
• 英文名称: (4-methyl-thiazol-5-yl)-acetic acid amide
• 英文别名: (4-Methyl-thiazol-5-yl)-essigsaeure-amid；2-(4-Methyl-1,3-thiazol-5-yl)acetamide
• CAS: 136384-13-9
• 化学式: C₆H₈N₂OS
• 分子量: 156.208
• InChiKey: ODYSYKNRCPOVRB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  84.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (4-甲基-噻唑-5-基)-乙酸酰胺 在 盐酸 、 钯 、 溶剂黄146 、 zirconium(IV) oxide 、 三氯氧磷 作用下， 生成 2-(4-甲基噻唑-5-基)乙胺
  参考文献：
  名称：

  An Amino Analog of Vitamin B₁

  摘要：

  DOI：

  10.1021/ja01849a049
• 作为产物：
  描述：

  4-甲基-5-乙酰基噻唑 在 1,4-二氧六环 、 ammonium polysulfide 、 sulfur 作用下， 生成 (4-甲基-噻唑-5-基)-乙酸酰胺
  参考文献：
  名称：

  Dornow; Petsch, Chemische Berichte, 1953, vol. 86, p. 1404,1406

  摘要：

  DOI：

文献信息

• SUBSTITUTED 2-(CHROMAN-6-YLOXY)-THIAZOLES AND THEIR USE AS PHARMACEUTICALS
  申请人：CZECHTIZKY Werngard

  公开号：US20130065859A1

  公开（公告）日：2013-03-14

  The present invention relates to substituted 2-(chroman-6-yloxy)-thiazoles of the formula I, in which Ar, R2, R3 and R4 are as defined in the claims. The compounds of the formula I are inhibitors of the sodium-calcium exchanger (NCX), especially of the sodium-calcium exchanger of subtype 1 (NCX1), and are suitable for the treatment of diverse disorders in which intracellular calcium homeostasis is disturbed, such as arrhythmias, heart failure and stroke. The invention furthermore relates to processes for the preparation of the compounds of the formula I, their use as pharmaceuticals, and pharmaceutical compositions comprising them.

  本发明涉及式I的取代2-(色甘醇-6-氧基)-噻唑衍生物，其中Ar、R2、R3和R4如权利要求中所定义。式I的化合物是钠-钙交换蛋白（NCX）的抑制剂，特别是亚型1的钠-钙交换蛋白（NCX1），适用于处理细胞内钙离子稳态受扰的各种疾病，如心律失常、心力衰竭和中风。本发明还涉及制备式I的化合物的方法，它们作为药物的用途，以及包含它们的药物组合物。
• Biaryl heterocyclic compounds and methods of making and using the same
  申请人：Zhou Jiacheng

  公开号：US20050203147A1

  公开（公告）日：2005-09-15

  The present invention relates generally to the field of anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. More particularly, the invention relates to a family of compounds having both a biaryl moiety and at least one heterocylic moiety that are useful as such agents.

  本发明通常涉及抗感染、抗增殖、抗炎和促动力药剂领域。更具体地，本发明涉及一类化合物家族，其具有双芳基基团和至少一个杂环基团，可用作上述药剂。
• BIARYL HETEROCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THE SAME
  申请人：Zhou Jiacheng

  公开号：US20090118502A1

  公开（公告）日：2009-05-07

  The present invention relates generally to the field of anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents. More particularly, the invention relates to a family of compounds having both a biaryl moiety and at least one heterocylic moiety that are useful as such agents.

  本发明一般涉及抗感染、抗增殖、抗炎和促动力剂领域。更具体地，本发明涉及一类化合物家族，其具有生物芳基基团和至少一个杂环基团，可以用作这些剂。
• SUBSITUTED 2-(CHROMAN-6-YLOXYL)-THIAZOLES AND THEIR USE AS PHARMACEUTICALS
  申请人：Sanofi

  公开号：US20140243292A1

  公开（公告）日：2014-08-28

  The present invention relates to substituted 2-(chroman-6-yloxy)-thiazoles of the formula I, in which Ar, R2, R3 and R4 are as defined in the claims. The compounds of the formula I are inhibitors of the sodium-calcium exchanger (NCX), especially of the sodium-calcium exchanger of subtype 1 (NCX1), and are suitable for the treatment of diverse disorders in which intracellular calcium homeostasis is disturbed, such as arrhythmias, heart failure and stroke. The invention furthermore relates to processes for the preparation of the compounds of the formula I, their use as pharmaceuticals, and pharmaceutical compositions comprising them.

  本发明涉及式I的取代2-(色烯-6-氧基)-噻唑，其中Ar，R2，R3和R4如权利要求所定义。公式I化合物是钠钙交换器（NCX）的抑制剂，特别是钠钙交换器亚型1（NCX1）的抑制剂，并适用于治疗细胞内钙离子稳态受到干扰的多种疾病，如心律失常，心力衰竭和中风。本发明还涉及制备公式I化合物的方法，它们作为药物的用途，以及包含它们的制药组合物。
• METHOD FOR TREATING, PREVENTING, OR REDUCING THE RISK OF SKIN INFECTION
  申请人：Melinta Therapeutics, Inc.

  公开号：US20160136137A1

  公开（公告）日：2016-05-19

  The present invention relates to methods for treating acne and other skin infections caused or mediated by Propionibacterium acnes, Gardnerella vaginalis , or Staphylococcus aureus in a patient with a safe and effective amount of a topically applied oxazolidinone antibiotic compound.

  本发明涉及使用局部应用的噁唑烷酮类抗生素化合物的安全有效量治疗因丙酸杆菌、阴道嗜酸杆菌或金黄色葡萄球菌引起或介导的痤疮和其他皮肤感染的方法。