N,N'-bis(N-L-tryptophan)-1,5-diaminopentane | 794529-73-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: N,N'-bis(N-L-tryptophan)-1,5-diaminopentane
• 英文别名: (2S)-2-amino-N-[5-[[(2S)-2-amino-3-(1H-indol-3-yl)propanoyl]amino]pentyl]-3-(1H-indol-3-yl)propanamide
• CAS: 794529-73-0
• 化学式: C₂₇H₃₄N₆O₂
• 分子量: 474.606
• InChiKey: DCYPXRTXUQTEHT-GOTSBHOMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  35
• 可旋转键数：
  12
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  142
• 氢给体数：
  6
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  N-苄氧羰基-L-色氨酸 在 氢溴酸 、 溶剂黄146 、 N,N'-二环己基碳二亚胺 作用下， 以 四氢呋喃 、 乙二醇二甲醚 为溶剂， 反应 33.0h， 生成 N,N'-bis(N-L-tryptophan)-1,5-diaminopentane
  参考文献：
  名称：

  Bis(amino amides) derived from natural amino acids as chiral receptors for N-protected dicarboxylic amino acids

  摘要：

  A family of bis(amino amides) derived from natural amino acids has been synthesized and tested for the NMR enantiodiscrimination, as chiral receptors, of some N-protected dicarboxylic amino acids. The influence of the amino acid side chain is an important parameter to obtain good enantiodiscrimination. The binding between bis(amino amides) and N-protected dicarboxylic amino acids has been thoroughly studied by ESI-MS and NMR spectroscopic methods as well as by molecular modeling. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.10.099

文献信息

• Bis(amino amides) derived from natural amino acids as chiral receptors for N-protected dicarboxylic amino acids
  作者：Belén Altava、M. Isabel Burguete、Noèlia Carbó、Santiago V. Luis、Vicente Martí-Centelles、Cristian Vicent

  DOI：10.1016/j.tetlet.2012.10.099

  日期：2013.1

  A family of bis(amino amides) derived from natural amino acids has been synthesized and tested for the NMR enantiodiscrimination, as chiral receptors, of some N-protected dicarboxylic amino acids. The influence of the amino acid side chain is an important parameter to obtain good enantiodiscrimination. The binding between bis(amino amides) and N-protected dicarboxylic amino acids has been thoroughly studied by ESI-MS and NMR spectroscopic methods as well as by molecular modeling. (C) 2012 Elsevier Ltd. All rights reserved.