1,1-diethoxy-3-methyl-2-pentanone | 497845-70-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1,1-diethoxy-3-methyl-2-pentanone
• 英文别名: 1,1-diethoxy-3-methylpentan-2-one；1,1-diethyloxy-3-methylpentan-2-one；sek.-Butyl-glyoxal-diaethylacetal；1,1-Diaethoxy-3-methyl-pentan-2-on
• CAS: 497845-70-2
• 化学式: C₁₀H₂₀O₃
• 分子量: 188.267
• InChiKey: JJBYCYRLQMWRBQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  13
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1,1-diethoxy-3-methyl-2-pentanone 在 甲醇 、 羟胺 作用下， 生成 2-hydroxyimino-3-methyl-valeraldehyde diethylacetal
  参考文献：
  名称：

  Newbold et al., Journal of the Chemical Society, 1951, p. 2679,2681

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 氢氧化钾 作用下， 生成 1,1-diethoxy-3-methyl-2-pentanone
  参考文献：
  名称：

  Density and Water Exchange-Dependent Growth and Survival of Litopenaeus setiferus Postlarvae

  摘要：

  AbstractThis present study was designed to investigate the effects of stocking density and water exchange on the growth rate, survival and performance index of L. setiferus postlarvae under controlled laboratory conditions. The experiment was done with postlarvae (PL10 to PL40) at densities of 50, 150, 250 and 350 shrimp/m2 and various different water exchanges rate per day (0, 6, 12 and 18%). The maximum growth rate was obtained for shrimp with 12% water exchange per day at all densities. A reduction of the maximum growth rate was observed in relation to density with the highest values in shrimp stocked in a density of 50 and 150 shrimp/m2 (mean value of 0.53 mg/d) and the lowest in shrimp stocked in a density of 350 shrimp/m2 (0.24 mg/d). The multiple regression equation obtained to relate performance index (growth rate* survival : PI), shrimp density (X1) and water exchange (X2) was: PI = 0.31 + (0.001) X1+ 0.039 X2+ 2.28 × 10−6 X12+ (−0.0017) X22+ (0.000026)X1X2,R2= 0.78; P > 0.03. According to this equation the optimum shrimp density‐water exchange comhination was between 5 to 12% of water exchange at stocking density of between 50 and 150 shrimp/m2. Salinity, ammonia‐N and nitrite‐N increased according to the time spent in tanks without water exchange. With no (0%) water exchange, water quality parameters measured were outside the optimum for L. setiferus postlarvae. The use of optimum density and water exchange in a nursery system for L. setiferus with optimum variables established is proposed.

  DOI：

  10.1111/j.1749-7345.2001.tb01091.x

文献信息

• A CONVENIENT METHOD FOR THE PREPARATION OF α-KETOACETALS
  作者：Maciej Adamczyk、Donald D. Johnson、Phillip G. Mattingly、You Pan、Rajarathnam E. Reddy

  DOI：10.1081/scc-120013744

  日期：2002.1.1

  ABSTRACT A convenient method for the preparation of α-ketoacetal derivatives 2a–g was developed by addition of Grignard reagent (1a–g) to commercially available ethyl diethoxyacetate (3) in 60–96% yield.

  摘要 通过将格氏试剂 (1a-g) 添加到市售的二乙氧基乙酸乙酯 (3) 中，以 60-96% 的产率开发了一种制备 α-酮缩醛衍生物 2a-g 的简便方法。
• Chemical studies on the BRET system between the bioluminescence of Cypridina and quantum dots
  作者：Chun Wu、Kosei Kawasaki、Satoru Ohgiya、Yoshihiro Ohmiya

  DOI：10.1039/c1pp05092c

  日期：2011.10

  We report a bioluminescence resonance energy transfer (BRET) system between Cypridina luciferase (Cluc) and QDs. After coupling of the biotinylated Cluc with streptavidin-QDs, a BRET emission of QDs through the resonance energy transfer from the oxidation of Vargula (Cypridina) luciferin was observed. A luciferin analogue having a naphtyl group at C6-position showed a large blue shift of the emission

  我们报告了Cypridina荧光素酶（Cluc）和QDs之间的生物发光共振能量转移（BRET）系统。在将生物素化的Cluc与链霉亲和素QD偶联后，观察到通过Vargula（Cypridina）荧光素氧化产生的共振能量转移，QD的BRET发射。在C6-位具有萘基的荧光素类似物显示出发射光谱的大蓝移，这改善了该BRET系统的比率。将荧光素酶与QD直接缀合后，观察到有效的BRET，类似于先前使用有机染料的BRET。此外，量子点的对称发射光谱显示了使用相同的荧光素在基于Cluc的BRET的基础上实现多重成像的潜力。
• Convergent and short-step syntheses of dl-Cypridina luciferin and its analogues based on Pd-mediated cross couplings
  作者：Hideshi Nakamura、Mihoko Aizawa、Daisuke Takeuchi、Akio Murai、Osamu Shimoura

  DOI：10.1016/s0040-4039(00)00131-3

  日期：2000.3

  luciferin and its analogues were synthesized from 2-aminopyrazine by an eight-step method that included two regio-selective Pd-mediated cross couplings, and their chemi- and bioluminescent activities were compared. Analogues having a 3-benzofuranyl or a 3-benzothienyl group in the place of a 3-indolyl group showed luciferase affinities similar to Cypridina luciferase but with a lower luminescent efficiency

  通过八步法从2-氨基吡嗪合成了dl- Cypridina luciferin及其类似物，该方法包括两个区域选择性Pd介导的交叉偶联，并比较了它们的化学发光和生物发光活性。具有3-苯并呋喃基或3-苯并噻吩基取代3-吲哚基的类似物显示出类似于Cypridina luciferase的萤光素酶亲和力，但发光效率较低，这表明NH基对于分子识别并不重要，而吲哚基是对于有效发光至关重要。
• Syntheses and evaluation of the bioluminescent activity of (S)-Cypridina luciferin and its analogs
  作者：Chun Wu、Kosei Kawasaki、Satoru Ohgiya、Yoshihiro Ohmiya

  DOI：10.1016/j.tetlet.2005.11.119

  日期：2006.1

  the presence of Cypridina luciferase was about 1.7 times as active as that of racemic form. Furthermore, several luciferin analogs prepared by the same condensation with different α-ketoacetal derivatives showed moderate light yield with Cypridina luciferase. These readily available Cypridina luciferin and analogs are applicable to the bioluminescent detection of Cypridina luciferase.

  赛氏丝虫萤光素是发光的球形赛氏丝虫（姬菇）hilgendorfii的生物发光的底物。球藻萤光素在仲丁基部分中含有一个手性中心。在这里，我们报告了通过（S）-1,1-二乙氧基-3-甲基戊-2--2-与硫代荧光素的缩合来制备（S）-Cypridina luciferin的简便方法。合成（S荧光素酶荧光素酶的存在下，）-荧光素的活性约为外消旋形式的活性的1.7倍。此外，通过用不同的α-酮缩醛衍生物相同的缩合反应制备的几种荧光素类似物在赛普里迪纳荧光素酶中显示出中等的光产量。这些容易获得的丝藻荧光素和类似物可用于丝藻荧光素酶的生物发光检测。
• LUMINESCENT VARGULA LUCIFERIN SUBSTRATE AND PROCESS FOR PRODUCING THE SAME
  申请人：National Institute of Advanced Industrial Science and Technology

  公开号：EP1930332B1

  公开（公告）日：2015-06-03