3-(5-amino-4-cyanopyrazol-1-yl) benzoic acid | 162339-93-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-(5-amino-4-cyanopyrazol-1-yl) benzoic acid
• 英文别名: 3-(5-amino-4-cyanopyrazol-1-yl)benzoic acid；3-(5-amino-4-cyano-1H-pyrazol-1-yl)benzoic acid
• CAS: 162339-93-7
• 化学式: C₁₁H₈N₄O₂
• mdl: MFCD09045256
• 分子量: 228.21
• InChiKey: VUTCQUAPFBCQKK-UHFFFAOYSA-N

物化性质

• 沸点：
  544.3±45.0 °C(Predicted)
• 密度：
  1.45±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  105
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3-(5-amino-4-cyanopyrazol-1-yl) benzoic acid 在 sodium hydroxide 、 硫酸 、 溶剂黄146 、 丙酸 、 三乙胺 、 sodium nitrite 作用下， 反应 1.83h， 生成
  参考文献：
  名称：

  Moura, Joao C.V.P.; Oliveira-Campos, Ana M.F.; Griffiths, John, Journal of Chemical Research, Miniprint, 1995, # 4, p. 924 - 937

  摘要：

  DOI：
• 作为产物：
  描述：

  3-肼基苯甲酸 、 乙氧基亚甲基丙二腈 以 乙醇 为溶剂， 反应 3.0h， 以76%的产率得到3-(5-amino-4-cyanopyrazol-1-yl) benzoic acid
  参考文献：
  名称：

  Mnk1 or Mnk2 inhibitors

  摘要：

  本发明涉及包含吡唑并嘧啶化合物的新型药物组合物。此外，本发明涉及利用本发明的吡唑并嘧啶化合物制备用于预防和/或治疗可能受到Mnk1和/或Mnk2（Mnk2a或Mnk2b）的激酶活性抑制影响的疾病的药物组合物。

  公开号：

  EP1746099A1

文献信息

• MNK1 or MNK2 Inhibitors
  申请人：Coulter Thomas Stephen

  公开号：US20090163520A1

  公开（公告）日：2009-06-25

  The present invention relates to the use of pyrazolopyrimidine compounds for the production of pharmaceutical compositions for the prophylaxis and/or treatment of diseases which can be influenced by the inhibition of the kinase activity of Mnk1 and/or Mnk2 (Mnk2a or Mnk2b) and/or variants thereof.

  本发明涉及使用吡唑并嘧啶化合物制备药物组合物，用于预防和/或治疗可以通过抑制Mnk1和/或Mnk2（Mnk2a或Mnk2b）激酶活性及/或其变体影响的疾病。
• MNK1 OR MNK2 INHIBITORS
  申请人：DeveloGen Aktiengesellschaft

  公开号：EP1827444A2

  公开（公告）日：2007-09-05
• PROCESS FOR PRODUCING 5-AMINOPYRAZOLE DERIVATIVE, AND AZO DYE
  申请人：Tateishi Keiichi

  公开号：US20100063262A1

  公开（公告）日：2010-03-11

  A process for producing a 5-aminopyrazole derivative represented by Formula (I) includes a step of reacting a hydrazine compound represented by Formula (II) with a compound represented by Formula (III) under a condition satisfying Reaction Condition 1 and Reaction Condition 2, wherein Reaction Condition 1 is that the reaction is conducted in a reaction solvent containing water, and Reaction Condition 2 is that pH of a liquid mixture containing the hydrazine compound represented by Formula (II), the compound represented by Formula (III), the reaction solvent, and an acidifying agent upon charging is within a range of from 2.0 to 4.0 at 25° C.: wherein the symbols in the formulae (I) to (III) are defined in the specification.
• COLORING MATTER, INK, INK FOR INK JET, INK JET RECORDING METHOD, COLOR TONER, AND COLOR FILTER
  申请人：Tateishi Keiichi

  公开号：US20120088910A1

  公开（公告）日：2012-04-12

  [Problem] To provide a coloring matter which has a good hue, and is capable of forming an image high in fastness property under various use conditions and environmental conditions, and particularly suitable for an ink. [Solving Means] A coloring matter represented by the following formula (I): wherein in the formula, G represents a heterocyclic group, and n represents an integer of 1 to 3; when n is 1, R, X, Y, Z, Q, and G each represents a monovalent group; when n is 2, R, X, Y, Z, Q, and G each represents a monovalent or divalent substituent, provided that at least one represents a divalent substituent; and when n is 3, R, X, Y, Z, Q, and G each represents a monovalent, divalent or trivalent substituent, provided that at least two each represents a divalent substituent, or at least one represents a trivalent substituent.
• NOVEL AZO COMPOUND, AQUEOUS SOLUTION, INK COMPOSITION, INK FOR INKJET RECORDING, INKJET RECORDING METHOD, INK CARTRIDGE FOR INKJET RECORDING, AND INKJET RECORD
  申请人：FUJIFILM CORPORATION

  公开号：US20130139723A1

  公开（公告）日：2013-06-06

  There is provided an aqueous solution including: (a) a preservative, and (b) at least one kind of an azo compound represented by the following Formula (1) or a salt thereof, wherein a content of (b) is 1% by mass to 25% by mass: wherein, in Formula (1), A represents a substituted phenyl group or a substituted or unsubstituted nitrogen-containing 5-membered heterocyclic group, G represents a nitrogen atom or —C(R 2 )═, R 2 represents a hydrogen atom, a sulfo group, a carboxy group, a substituted or unsubstituted carbamoyl group or cyano group, Y 2 , Y 3 and Y 4 each independently represents a hydrogen atom or a monovalent substituent, Y 2 , Y 3 and Y 4 may be bonded to each other to form a ring, all of Y 2 , Y 3 and Y 4 do not represent a hydrogen atom at the same time, and M each independently represents a hydrogen atom or a monovalent countercation.